Article
Cell Biology
Yuan Qian, Gabriel Arellano, Igal Ifergan, Jean Lin, Caroline Snowden, Taehyeung Kim, Jane Joy Thomas, Calvin Law, Tianxia Guan, Roumen D. Balabanov, Susan M. Kaech, Stephen D. Miller, Jaehyuk Choi
Summary: Inappropriate CD4(+) T cell differentiation can affect immune response and autoimmune diseases. The study identified a key role for Zinc finger E-box-binding homeobox (ZEB1) in regulating autoimmune inflammation, particularly through inhibition of JAK-STAT signaling. ZEB1 and JAK2 downregulation reduces pathogenic cytokine expression in T cells from MS patients, suggesting a potential targetable mechanism for regulating disease-related inflammation.
Review
Biochemistry & Molecular Biology
Stefano Piazza, Marco Fumagalli, Giulia Martinelli, Carola Pozzoli, Nicole Maranta, Marco Angarano, Enrico Sangiovanni, Mario Dell'Agli
Summary: Plants rich in hydrolyzable tannins have traditionally been used for the treatment of chronic inflammatory disorders. However, limited knowledge of their immunological targets hinders their rational use in phytotherapy. Recent advances in understanding the pathogenesis of inflammatory-based diseases provide an opportunity to elucidate the pharmacological mechanisms of these plant-derived metabolites with immunomodulatory activity. This review summarizes recent articles on the role of hydrolyzable tannins and their gut metabolites in various inflammatory responses.
Article
Multidisciplinary Sciences
Nadira Vadaq, Lisa van de Wijer, Louise E. van Eekeren, Hans Koenen, Quirijn de Mast, Leo A. B. Jooster, Mihai G. Netea, Vasiliki Matzaraki, Andre J. A. M. van der Ven
Summary: In this study, the researchers compared the plasma inflammatory protein concentrations between people living with HIV (PLHIV) on antiretroviral therapy (ART) and healthy controls. The results showed that PLHIV exhibited higher levels of inflammatory proteins, and those with high inflammation had an increased risk of developing malignancies and cardiovascular events. PD-L1, VEGFA, LAP TGF b-1, and TNFRSF9 were identified as the best predictors for distinguishing the two inflammatory states.
Article
Immunology
Jiyoon Park, Min-Ji Son, Chun-Chang Ho, Su-Hyeon Lee, Yuna Kim, Jaekyeung An, Sang-Kyou Lee
Summary: This study demonstrates that ndSTAT1-TMD can modulate the functions of Th1 and Th17 cells, making it a potential new therapeutic agent for Th1/17 cell-mediated autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Yiting Lin, Ke Xue, Qingyang Li, Zhenhua Liu, Zhenlai Zhu, Jiaoling Chen, Erle Dang, Lei Wang, Weigang Zhang, Gang Wang, Bing Li
Summary: This study reveals that CDK7 promotes CD4(+) T-cell activation and Th17/Th1 cell differentiation by regulating glycolysis, thus contributing to the pathogenesis of psoriasis. Targeting CDK7 might be a promising immunosuppressive strategy to control skin inflammation mediated by IL-23.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Genetics & Heredity
Carlos Menendez-Castro, Nada Cordasic, Fabian B. Fahlbusch, Arif B. Ekici, Philipp Kirchner, Christoph Daniel, Kerstin Amann, Roland Velkeen, Joachim Woelfle, Mario Schiffer, Andrea Hartner, Karl F. Hilgers
Summary: In malignant hypertension, the most severe hypertension-induced kidney injury occurs. In a rat model of malignant hypertension, a broad stimulation of inflammatory mechanisms was observed, but specific pathways, such as activation of the complement cascades, were activated only in the malignant form of the disease. Complement inhibitors may alleviate the thrombotic microangiopathy of malignant hypertension even in the absence of primary complement abnormalities.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Medicine, General & Internal
Andrea Itano, Douglas Maslin, Kritika Ramani, Golbarg Mehraei, Nancy Carpenter, Taylor Cormack, Mahdi Saghari, Matthijs Moerland, Erin Troy, Will Caffry, Leslie Wardwell-Scott, Stuart Abel, Duncan McHale, Mark Bodmer
Summary: This study introduces EDP1815, a non-colonizing pharmaceutical preparation derived from a single strain of Prevotella histicola. The research demonstrates that EDP1815 can regulate inflammatory responses throughout the body when taken orally and restricted to the gut.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hua Ye, Dongdong Fu, Xiangyu Fang, Yang Xie, Xi Zheng, Wenqiang Fan, Fanlei Hu, Zhanguo Li
Summary: Studies have shown that CK2 plays a role in CD4(+) T cell proliferation and activation. In this study, it was found that CK2 expression is upregulated in CD4(+) T cells under RA conditions. Treatment with CX4945 inhibited Th1 and Th17 cell responses while promoting Th2 cell responses in RA patients and CIA mice, leading to a decrease in IFN-gamma and IL-17A production. Additionally, CX4945 treatment reduced the severity of arthritis in CIA mice by decreasing Th1 and Th17 cells, with minimal effect on RA Treg cells.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Article
Cell Biology
Kathryne E. Marks, Stephanie Flaherty, Kristen M. Patterson, Matthew Stratton, Gustavo J. Martinez, Joseph M. Reynolds
Summary: The study shows that activation of TLR2 increases the pathogenicity and migratory capacity of Th17 cells, comparable to IL-23. RNA sequencing revealed differential expression of genes associated with Th17 pathogenicity through the TLR2 pathway, including Ipcef1.
Review
Gastroenterology & Hepatology
Hui Cao, Jun Diao, Huosheng Liu, Suxian Liu, Jun Liu, Jianye Yuan, Jiang Lin
Summary: Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, are characterized by chronic idiopathic inflammation of the gastrointestinal tract. The pathogenesis of IBD is largely unknown, but it is believed that intestinal immune dysfunction plays a key role. Th1 and Th17 cells, which are essential for maintaining intestinal homeostasis, become pathogenic during the development of IBD and contribute to the inflammation and damage of the intestinal mucosa. Th1 cells impair intestinal epithelial cell function, while pathogenic Th17 cells induce injury and cell death. The synergistic action of Th1 and pathogenic Th17 cells exacerbates mucosal inflammation in IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Rebecca E. Tweedell, Sivakumar Prasanth Kumar, Thirumala-Devi Kanneganti
Summary: The past two decades of research have revealed new innate immune sensing and cell death pathways that are relevant to diseases. Further molecular characterization of these pathways and understanding their crosstalk and functional redundancies will contribute to the development of therapeutic strategies.
Article
Dermatology
Yunbo Wu, Xiaojian Li, Shiyu Chen, Tong Liu, Xiaomin Chen, Ping Zhan, Guirong Qiu
Summary: This study used Mendelian randomization (MR) design to explore the potential causal association between inflammatory bowel disease (IBD) and rosacea. The results showed a significant association between genetically predicted IBD and rosacea, with different subtypes of IBD having different degrees of association with rosacea.
DERMATOLOGIC THERAPY
(2023)
Article
Immunology
Wen-Hui Qi, Yan-Yan Zhang, Kun Xing, Dong-Xia Hao, Fei Zhang, Rui-Ning Wang, Ming-Yue Bao, Meng-Yuan Tian, Ya-Na Yang, Xing Li, Yuan Zhang
Summary: Using structure-based virtual screening, this study identified a compound called DDC, which is abundant in plants and food, as a potential immunomodulator. DDC inhibits the activity of ROR gamma t, a transcription factor involved in Th17 cell differentiation, thus regulating Th17/Treg balance and showing promise in the treatment of inflammatory diseases like multiple sclerosis, inflammatory bowel disease, and organ transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Daniel Chauss, Tilo Freiwald, Reuben McGregor, Bingyu Yan, Luopin Wang, Estefania Nova-Lamperti, Dhaneshwar Kumar, Zonghao Zhang, Heather Teague, Erin E. West, Kevin M. Vannella, Marcos J. Ramos-Benitez, Jack Bibby, Audrey Kelly, Amna Malik, Alexandra F. Freeman, Daniella M. Schwartz, Didier Portilla, Daniel S. Chertow, Susan John, Paul Lavender, Claudia Kemper, Giovanna Lombardi, Nehal N. Mehta, Nichola Cooper, Michail S. Lionakis, Arian Laurence, Majid Kazemian, Behdad Afzali
Summary: Research suggests that Vitamin D plays a crucial role in regulating the transcriptional response of T cells, leading to the transition from pro-inflammatory to suppressive cells. In patients with severe COVID-19, disruptions in Vitamin D signaling may be responsible for dysregulation of the immune system, resulting in increased inflammation.
Article
Multidisciplinary Sciences
Manik Kuchroo, Marcello DiStasio, Eric Song, Eda Calapkulu, Le Zhang, Maryam Ige, Amar H. Sheth, Abdelilah Majdoubi, Madhvi Menon, Alexander Tong, Abhinav Godavarthi, Yu Xing, Scott Gigante, Holly Steach, Jessie Huang, Guillaume Huguet, Janhavi Narain, Kisung You, George Mourgkos, Rahul M. Dhodapkar, Matthew J. Hirn, Bastian Rieck, Guy Wolf, Smita Krishnaswamy, Brian P. Hafler
Summary: The study used single-nucleus RNA sequencing to investigate the shared pathways and glial activation in age-related macular degeneration and other neurodegenerative diseases. They identified early-stage enriched glial populations and a signaling axis mediated by interleukin-1 beta in late-stage age-related macular degeneration. This study provides potential therapeutic targets for age-related macular degeneration and other neurodegenerative conditions.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Andrzej Olejniczak, Maria Lezanska, Aleksandra Pacula, Pawel Nowak, Jerzy Wloch, Jerzy P. Lukaszewicz
Article
Chemistry, Analytical
Magdalena Elzbieciak-Wodka, Marta Kolasinska-Sojka, Pawel Nowak, Piotr Warszynski
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2015)
Article
Electrochemistry
Maciej Tatko, Michal Mosialek, Aneta Kedra, Elzbieta Bielanska, Malgorzata Ruggiero-Mikolajczyk, Pawel Nowak
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2016)
Article
Chemistry, Applied
Aleksandra Pacula, Pawel Nowak, Waclaw Makowski, Robert P. Socha
MICROPOROUS AND MESOPOROUS MATERIALS
(2015)
Review
Dermatology
Martin Steinhoff, Martin Schmelz, Juergen Schauber
ACTA DERMATO-VENEREOLOGICA
(2016)
Review
Medicine, Research & Experimental
James R. Docherty, Martin Steinhoff, Dianne Lorton, Michael Detmar, Gregor Schafer, Anna Holmes, Anna Di Nardo
ADVANCES IN THERAPY
(2016)
Review
Medicine, Research & Experimental
Martin Steinhoff, Marc Vocanson, Johannes J. Voegel, Feriel Hacini-Rachinel, Gregor Schaefer
ADVANCES IN THERAPY
(2016)
Article
Chemistry, Physical
M. Kopec, K. Szczepanowicz, P. Warszynski, P. Nowak
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2016)
Article
Allergy
Micha Feld, Richard Garcia, Joerg Buddenkotte, Shintaro Katayama, Katherine Lewis, Gareth Muirhead, Peter Hevezi, Kristin Plesser, Holger Schrumpf, Kaarel Krjutskov, Olga Sergeeva, Hans Werner Mueller, Sophia Tsoka, Juha Kere, Stacey R. Dillon, Martin Steinhoff, Bernhard Homey
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Chemistry, Applied
Juliusz Adamski, Jolanta Kochana, Pawel Nowak, Andrzej Parczewski
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2016)
Article
Dermatology
Tasuku Akiyama, Margaret Ivanov, Masaki Nagamine, Auva Davoodi, Mirela I. Carstens, Akihiko Ikoma, Ferda Cevikbas, Cordula Kempkes, Joerg Buddenkotte, Martin Steinhoff, E. Carstens
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Review
Chemistry, Physical
J. Molenda, J. Kupecki, R. Baron, M. Blesznowski, G. Brus, T. Brylewski, M. Bucko, J. Chmielowiec, K. Cwieka, M. Gazda, A. Gil, P. Jasinski, Z. Jaworski, J. Karczewski, M. Kawalec, R. Kluczowski, M. Krauz, F. Krok, B. Lukasik, M. Malys, A. Mazur, A. Mielewczyk-Gryn, J. Milewski, S. Molin, G. Mordarski, M. Mosialek, K. Motylinski, E. N. Naumovich, P. Nowak, G. Pasciak, P. Pianko-Oprych, D. Pomykalska, M. Rekas, A. Sciazko, K. Swierczek, J. Szmyd, S. Wachowski, T. Wejrzanowski, W. Wrobel, K. Zagorski, W. Zajac, A. Zurawska
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2017)
Article
Multidisciplinary Sciences
Jianghui Meng, Jiafu Wang, Martin Steinhoff, James Oliver Dolly
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Physical
Konrad Skowron, Ewa Dryzek, Miroslaw Wrobel, Pawel Nowak, Marianna Marciszko-Wiackowska, Lea Le Joncour, Manuel Francois, Benoit Panicaud, Andrzej Baczmanski