Review
Biochemistry & Molecular Biology
Jussi Tuusa, Nina Kokkonen, Kaisa Tasanen
Summary: BP180 is a type II collagenous transmembrane protein, known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). Apart from its role in hemidesmosomes, BP180 is also expressed in non-HD locations with unclear functions. In addition to its immunological roles in BP, novel functions in cell proliferation, differentiation, and aging have recently been described.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yangdan Liu, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Lu Huang, Ya Gao, Qingfeng Li, Yifan Zhang
Summary: The self-renewal ability of stem cells is crucial for skin homeostasis, aging, and wound repair. COL17, as a component of the stem cell niche, plays a pivotal role in regulating stem cell maintenance and function.
Article
Immunology
Elise C. Wilcox, Elazer R. Edelman
Summary: Endothelial cells interact with and regulate the immune system, modulating immune cell function through the expression of various molecules and influencing immune recognition outcomes. Cell-substratum interactions impact endothelial cell phenotype and subsequently affect the immune response to transplanted cells. Endothelial cells grown on different substrata exhibit distinct basal expression levels and responsiveness to inflammatory stimuli. Understanding the relationship between endothelial cell substratum and allorecognition is crucial for predicting and modifying the outcome of endothelial cell-immune interactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Biochemical Research Methods
Yuqian Wang, Zhe Wang, Guideng Li
Summary: Engineered viral entry combined with single-cell sequencing technology allows for the identification of specific ligand-receptor interactions in a high-throughput manner.
Review
Biochemistry & Molecular Biology
Lynn Williams, Thomas Layton, Nan Yang, Marc Feldmann, Jagdeep Nanchahal
Summary: Fibrosis of visceral organs such as the lungs, heart, kidneys, and liver is a major cause of morbidity and mortality, and is also associated with other disorders like cancer and metabolic disease. Collagen VI, particularly in conditions like IPF and chronic liver and kidney diseases, has elevated expression and its chain fragments are emerging as important biomarkers for fibrotic conditions.
Article
Physics, Fluids & Plasmas
Russell K. W. Spencer, Bae-Yeun Ha, Nima Saeidi
Summary: This study presents a self-consistent field theory (SCFT) of chiral-nematic polymers, taking into account polymer flexibility and the orientational degrees of freedom. A phase diagram is constructed, showing the regions of stability for isotropic, nematic, and cholesteric phases. Furthermore, it is discovered that nematic interactions can stabilize the cholesteric phase.
Article
Oncology
Ryosuke Kashiwagi, Ryo Funayama, Shuichi Aoki, Aya Matsui, Sebastian Klein, Yukihiro Sato, Tsubasa Suzuki, Keigo Murakami, Koetsu Inoue, Masahiro Iseki, Kunihiro Masuda, Masamichi Mizuma, Hisamichi Naito, Dan G. Duda, Michiaki Unno, Keiko Nakayama
Summary: The expression of COL17A1 gene in tumor tissue is either positively or negatively associated with patient survival, depending on the type of cancer. High COL17A1 expression is a favorable prognostic marker for breast cancer, but unfavorable for pancreatic cancer. This study investigates the effects of COL17A1 expression on pancreatic tumor growth and its underlying mechanisms.
Article
Gastroenterology & Hepatology
Jack Leslie, Daniel Geh, Ahmed M. Elsharkawy, Derek A. Mann, Michele Vacca
Summary: HCV hijacks host metabolic processes to aid in viral replication, resulting in hepatic and extrahepatic metabolic dysfunction. Obesity, insulin resistance, and hepatic steatosis play key roles in the progression of chronic hepatitis C (CHC) to hepatocellular carcinoma (HCC). While direct-acting antivirals (DAAs) effectively eliminate the virus, long-lasting metabolic diseases can persist, particularly in the presence of obesity, increasing the risk of liver disease progression.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michael Ablinger, Thomas Lettner, Nicole Friedl, Hannah Potocki, Theresa Palmetzhofer, Ulrich Koller, Julia Illmer, Bernadette Liemberger, Stefan Hainzl, Alfred Klausegger, Manuela Reisenberger, Jo Lambert, Mireille Van Gele, Eline Desmet, Els Van Maelsaeke, Monika Wimmer, Roland Zauner, Johann W. Bauer, Verena Wally
Summary: Intermediate junctional epidermolysis bullosa caused by mutations in the COL17A1 gene is a rare disease with heterogeneous mutations, making therapy development challenging. However, the use of AON to induce exon skipping shows promise as a personalized treatment approach for this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pedro M. Garcia Eijo, Juan D'Adamo, Arturo Bianchetti, Thomas Duriez, Juan M. Cabaleiro, Celica Irrazabal, Pablo Otero, Guillermo Artana
Summary: In this study, a shared pressure-controlled ventilation device for two patients was considered. Experiments showed that connecting two patients in parallel to a ventilator always resulted in delays during exhalation, with the size of this effect depending on various parameters associated with the patients, circuit, and ventilator. The dynamics of exhalation of both patients were influenced by ratios between patients' exhalatory resistances, compliances, driving pressures, and PEEPs. Adverse effects on exhalations became less noticeable when respiratory parameters of both patients were similar and flow resistances of valves added to the circuit were negligible.
Article
Cell Biology
Lorena Suarez-Artiles, Tilman Breiderhoff, Rossana Girardello, Hannes Gonschior, Sophie Rodius, Antoine Lesur, Ulf Reimer, Evelyn Ramberger, Daniel Perez-Hernandez, Dominik Muller, Philipp Mertins, Gunnar Dittmar
Summary: This study investigates the interaction of the C-terminal tails of the Claudin family with other proteins, revealing their potential involvement in specific biological processes in epithelial cells and their regulation by post-translational modifications.
Article
Chemistry, Medicinal
Ian P. Smith, Marco Domingos, Stephen M. Richardson, Jordi Bella
Summary: Collagen is commonly used as a biomaterial in regenerative medicine and biomedical research, but its use is limited by sociological and ethical concerns. This study characterizes the properties of collagen derived from jellyfish and compares them with mammalian collagens, providing insights for using alternative collagen sources in biomedical research.
Article
Microbiology
Shan Zhang, Weizhi Song, Louis-Felix Nothias, Sneha P. Couvillion, Nicole Webster, Torsten Thomas
Summary: This study demonstrates the compartmentalization of different chemical functionalities between sponge hosts and their microbial symbionts, and provides new insights into the function of sponge holobionts.
Article
Multidisciplinary Sciences
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adela Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Summary: This study identifies three antibodies that have synergistic effects on a malaria vaccine candidate and demonstrates that lateral interactions between the antibodies slow dissociation and inhibit parasite growth. Understanding the mechanisms of antibody synergy is crucial for vaccine design and antibody cocktail development.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Kenneth M. Yamada, Andrew D. Doyle, Jiaoyang Lu
Summary: Cell-ECM interactions are essential in development, diseases, and tissue remodeling. Recent advances in research have provided detailed descriptions of ECM molecules, identified distinct modes of cell migration in different ECM environments, and offered new insights into organ formation mechanisms. The dynamic nature of these interactions and the feedback loops involved can contribute to disease progression.
TRENDS IN CELL BIOLOGY
(2022)
