Article
Multidisciplinary Sciences
Kyu Hye Choi, Jin Ho Song, Yoo-Kang Kwak, Jong Hoon Lee, Hong Seok Jang
Summary: This study analyzed the association between PET-CT variables and the response to radiotherapy in patients with myeloid sarcoma. Good metabolic responses were achieved in 92.6% of the patients after radiotherapy. High SUVmax before radiotherapy was found to influence the reduction in SUVmax.
Article
Oncology
Peter H. Goff, Laura Riolobos, Bonnie J. LaFleur, Matthew B. Spraker, Y. David Seo, Kimberly S. Smythe, Jean S. Campbell, Robert H. Pierce, Yuzheng Zhang, Qianchuan He, Edward Y. Kim, Stephanie K. Schaub, Gabrielle M. Kane, Jose G. Mantilla, Eleanor Y. Chen, Robert Ricciotti, Matthew J. Thompson, Lee D. Cranmer, Michael J. Wagner, Elizabeth T. Loggers, Robin L. Jones, Erin Murphy, Wendy M. Blumenschein, Terrill K. McClanahan, Jon Earls, Kevin C. Flanagan, Natalie A. LaFranzo, Teresa S. Kim, Seth M. Pollack
Summary: This study aims to characterize the changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy and provides insights for neoadjuvant immunotherapy trial design. The results show that neoadjuvant therapy significantly increases immune cell infiltration in the tumor and affects the expression of immune-related genes and cytokines. These findings inform the incorporation of immune checkpoint inhibitors and novel immunotherapies into the neoadjuvant setting for STSs.
CLINICAL CANCER RESEARCH
(2022)
Article
Environmental Sciences
Bin Wang, Shu-qin Zhang, Jia-li Dong, Yuan Li, Yu-xiao Jin, Hui-wen Xiao, Hai-chao Wang, Sai-jun Fan, Ming Cui
Summary: This study investigated the effects of temperature on the radiosensitivity of zebrafish and identified potential biochemical mechanisms responsible for influencing radiosensitivity. The results suggest that gut microbiota configurations shaped by different temperatures may play a key role in modulating hepatic functions and radiosensitivity in zebrafish. Maintaining the stability of gram-positive bacteria could be efficacious in protecting aquatic organisms against radioactive contamination in the context of global climate change.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Francesca Amoroso, Kimberley Glass, Reema Singh, Francisco Liberal, Rebecca E. Steele, Sarah Maguire, Rohinton Tarapore, Joshua E. Allen, Sandra Van Schaeybroeck, Karl T. Butterworth, Kevin Prise, Joe M. O'Sullivan, Suneil Jain, David J. Waugh, Ian G. Mills
Summary: The study demonstrated that ONC201 can enhance the radiation response of prostate cancer cells by suppressing the expression of cell cycle and DNA repair factors.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kunal K. Sindhu, Anthony D. Nehlsen, Eric J. Lehrer, Jared P. Rowley, Richard G. Stock, Matthew D. Galsky, Michael Buckstein
Summary: Ablative radiation therapy may benefit patients who experience oligoprogression on immune checkpoint inhibitors by extending the lifespan of the treatment. However, overall survival in this population appears to be excellent.
Article
Multidisciplinary Sciences
Kai J. Borm, Yannis Junker, Mathias Duesberg, Michal Devecka, Stefan Muench, Hendrik Dapper, Markus Oechsner, Stephanie E. Combs
Summary: The study showed that the frequency of CBCT during adjuvant breast cancer radiotherapy with SIB does not significantly impact target volume coverage or dose to OAR. Daily CBCT imaging may not be necessary to ensure adequate dose coverage in target volumes while efficiently sparing OAR.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Hem D. Shukla, Tijana Dukic, Sanjit Roy, Binny Bhandary, Andrew Gerry, Yannick Poirier, Narottam Lamichhane, Jason Molitoris, France Carrier, Aditi Banerjee, William F. Regine, Jerimy C. Polf
Summary: This study investigated the potential of using three-dimensional pancreatic tumor organoids (PTOs) to evaluate the sensitivity and response of pancreatic cancer to radiation therapy (RT) and combined chemo-RT. The results showed that PTOs exhibited a similar microenvironment and growth characteristics as in vivo tumors, indicating their potential for predicting in vivo tumor sensitivity and response to RT and combined chemo-RT treatments.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Thomas Friedrich, Nicholas Henthorn, Marco Durante
Summary: The combination of immune therapy with radiation presents a promising treatment modality in cancer therapy, but challenges remain in the effective clinical implementation. These include determining optimal drug and radiation dose schedules, the amount of damage and associated doses required, and the impact of lymphocyte status and dynamics. Biophysical modeling can offer insights into addressing these factors and mechanisms of action.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Graham H. Read, Justine Bailleul, Erina Vlashi, Aparna H. Kesarwala
Summary: Tumor metabolism is crucial for cancer progression, with recent studies suggesting that metabolic plasticity in cancer cells could reduce the effectiveness of anticancer therapies. Understanding radiation-induced metabolic changes can help identify new therapeutic targets, but there is a lack of robust studies characterizing these changes in cancer.
MOLECULAR CARCINOGENESIS
(2022)
Review
Oncology
Kyle Wiatrowski, Tae Hee Kim, Amanda Przespolewski
Summary: This article provides an overview of recent advancements in immunotherapy for AML, focusing on biomarkers of response. The topics covered include antibody drug conjugates, BiTEs, DARTs, checkpoint inhibitors, cellular therapy, and the development of predictive biomarkers for response in each class.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Eymeric Le Reun, Adeline Granzotto, Adeline Petre, Larry Bodgi, Guillaume Beldjoudi, Thomas Lacornerie, Veronique Vallet, Audrey Bouchet, Joelle Al-Choboq, Michel Bourguignon, Juliette Thariat, Jean Bourhis, Eric Lartigau, Nicolas Foray
Summary: We demonstrated the occurrence of hypersensitivity to low dose (HRS) phenomenon in both tumor and healthy cells in SBRT modality. The response to SBRT was found to be exacerbated in HRS-positive cells, leading to the appearance of a subset of highly damaged cells that can enhance the treatment efficiency. It is important to determine the HRS status of tumors and healthy tissues to increase SBRT efficiency and reduce the risk of adverse reactions.
Article
Multidisciplinary Sciences
Yipeng He, Sijia Chen, Xiang Gao, Lirong Fu, Zheng Kang, Jun Liu, Liwan Shi, Yimin Li
Summary: This study found that in postmastectomy radiotherapy for breast cancer, using a 5 mm bolus in volumetric modulated arc therapy (VMAT) provides better target coverage and organ-at-risk sparing compared to a 10 mm bolus.
Article
Multidisciplinary Sciences
Anamitra Majumdar, Nader Allam, W. Jeffrey Zabel, Valentin Demidov, Costel Flueraru, I. Alex Vitkin
Summary: This study introduces an AI analysis method based on optical coherence tomography for evaluating tumor microvascular responses to radiation. The results demonstrate that AI can successfully classify microvascular changes at different radiation dose levels, providing a new approach for predicting treatment outcomes in radiation therapy.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Kun Qing, Ke Nie, Bo Liu, Xue Feng, James R. Stone, Taoran Cui, Yin Zhang, Jiahua Zhu, Quan Chen, Xiao Wang, Li Zhao, Shreel Parikh, John P. Mugler, Sung Kim, Joseph Weiner, Ning Yue, Anupama Chundury
Summary: This study evaluated the pattern and extent of optic nerve (ON) movement using MRI and investigated its potential dosimetric effect in radiotherapy. The results showed that the anterior portions of optic nerves have significant movement, which should be considered during radiation therapy for peri-optic lesions.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Christine Birdwell, Warren Fiskus, Tapan M. Kadia, Courtney D. DiNardo, Christopher P. Mill, Kapil N. Bhalla
Summary: EVI1 is an oncogenic zinc-finger transcription factor that is overexpressed in myeloid malignancies and correlates with poor clinical outcomes. Despite advancements in understanding the biology of EVI1 dysregulation, significant improvements in therapeutic outcomes remain elusive.
BLOOD CANCER JOURNAL
(2021)
Article
Oncology
Ayman J. Oweida, Adam C. Mueller, Miles Piper, Dallin Milner, Benjamin Van Court, Shilpa Bhatia, Andy Phan, Thomas Bickett, Kimberly Jordan, Theresa Proia, Richard Schulick, Wells A. Messersmith, Marco Del Chiaro, Eric Clambey, Michael J. Gough, Jason Williams, Kirk Hansen, Karyn Goodman, Sana D. Karam
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a heterogeneous tumor microenvironment, and targeting STAT3 in combination with RT can mitigate the pro-tumorigenic effects of RT and improve tumor response by reducing RT-induced MDSC infiltration and increasing effector T cell proportion.STAT3 inhibition also contributes to the remodeling of the PDAC extracellular matrix when combined with RT, resulting in decreased collagen deposition and fibrotic tissue formation. Overall, the study provides evidence that targeting STAT3 in combination with RT is a promising approach to enhance the anti-tumor effects of radiotherapy in PDAC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Tiffany C. Blair, Alejandro F. Alice, Lauren Zebertavage, Marka R. Crittenden, Michael J. Gough
Summary: Traditional methods of analyzing tumor infiltration provide a snapshot view of lymphocyte interactions with the tumor environment. However, lymphocytes have the unique ability for continued recirculation, exploring various tissues for cognate antigens based on inflammatory triggers and chemokine gradients. The inflammatory and cellular makeup of the tumor environment, as well as antigen expression by cancer cells or cross-presentation by stromal antigen presenting cells, impact the recirculation kinetics of T cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Alejandro F. Alice, Gwen Kramer, Shelly Bambina, Keith S. Bahjat, Michael J. Gough, Marka R. Crittenden
Summary: The study found that direct infection of human monocyte-derived dendritic cells with Listeria monocytogenes can trigger the activation of Vγ9Vδ2 T cells, even without the production of the unique bacterial ligand HMBPP. This activation is dependent on functional BTN3A1, and cytoplasmic entry of Lm into host cells can also upregulate cholesterol metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Shay Sharon, Thomas Duhen, Shelly Bambina, Jason Baird, Rom Leidner, Bryan Bell, Nardy Casap, Marka Crittenden, Swetha Vasudevan, Maria Jubran, Nataly Kravchenko-Balasha, Michael Gough
Summary: Patients exhibit distinct responses to immunotherapies, even when matched for baseline tumor environments, indicating that the biological response to treatment cannot currently be predicted accurately through snapshot analysis of tumor infiltrates. Further research is needed to better understand the relationship between the immune environment of tumors and responses to therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Tiffany C. Blair, Shelly Bambina, Gwen F. Kramer, Alexa K. Dowdell, Alejandro F. Alice, Jason R. Baird, Amanda W. Lund, Brian D. Piening, Marka R. Crittenden, Michael J. Gough
Summary: This study demonstrates that the immunological efficacy of radiation therapy depends on cDC migration in radioimmunogenic tumors. Furthermore, the combination of an exogenous adjuvant with radiation therapy can increase the migration of cDCs in poorly radioimmunogenic tumors.
LIFE SCIENCE ALLIANCE
(2022)
Article
Oncology
Tomoko Yamazaki, Andrew J. Gunderson, Miranda Gilchrist, Mark Whiteford, Maria X. Kiely, Amanda Hayman, David O'Brien, Rehan Ahmad, Jeffrey Manchio, Nathaniel Fox, Kayla McCarty, Michaela Phillips, Evelyn Brosnan, Gina Vaccaro, Rui Li, Miklos Simon, Eric Bernstein, Mary McCormick, Lena Yamasaki, Yaping Wu, Ashley Drokin, Trevor Carnahan, Yy To, William L. Redmond, Brian Lee, Jeannie Louie, Eric Hansen, Matthew C. Solhjem, Julie Cramer, Walter J. Urba, Michael J. Gough, Marka R. Crittenden, Kristina Young
Summary: The addition of galunisertib to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer improved the complete response rate to 32%, was well tolerated, and warrants further assessment in randomized trials.
Article
Multidisciplinary Sciences
Tiffany Blair, Jason Baird, Shelly Bambina, Gwen Kramer, Monica Gostissa, Christopher J. Harvey, Michael J. Gough, Marka R. Crittenden
Summary: This study demonstrates that radiation therapy increases the expression of ICOS on T cells and combining a novel ICOS agonist antibody with radiation leads to durable tumor control in preclinical models. CD8 T cells are essential for treatment efficacy, while CD4 T cells and NK cells also contribute partially. The combination therapy reduces the infiltration of regulatory T cells into tumors, which is typically increased after radiation alone.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Michael J. Gough, Marka R. Crittenden
Summary: This review discusses a paradox in immunotherapies based on radiation therapy, where radiation therapy requires the involvement of T cells but kills T cells in the treatment field. The authors examine the impact of radiation on T cells and their movement in and out of tissues and tumors, explaining the reliance of the extraordinary efficacy of radiation and immunity in preclinical models on these radiation-sensitive cells.
Article
Multidisciplinary Sciences
Terry R. R. Medler, Gwen Kramer, Shelly Bambina, Andrew J. J. Gunderson, Alejandro Alice, Tiffany Blair, Lauren Zebertavage, Thomas Duhen, Rebekka Duhen, Kristina Young, Marka R. R. Crittenden, Michael J. J. Gough
Summary: Tissue resident memory (Trm) CD8 T cells infiltrating tumors have tumor antigen-specificity, and their presence is associated with improved outcomes. Tumor implantation generates a Trm niche dependent on antigen presentation by cancer cells. Localization of CD8 T cells to tumor draining lymph nodes is necessary for the subsequent generation of CD103(+) CD8 T cells in tumors, which is CD40L-dependent but independent of CD4 T cells. CD8 T cells can provide their own CD40L for CD103(+) CD8 T cell differentiation. CD40L is required for systemic protection against secondary tumors.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Terry R. Medler, Tiffany C. Blair, Alejandro F. Alice, Alexa K. Dowdell, Brian D. Piening, Marka R. Crittenden, Michael J. Gough
Summary: Radiation therapy induces immunogenic cell death in cancer cells, and the released endogenous adjuvants are sensed by immune cells to direct adaptive immune responses. MyD88 signaling in myeloid cells is identified as a critical source of immunosuppression in hinder adaptive immune tumor control following radiation therapy in pancreatic cancer.
SCIENTIFIC REPORTS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Shay Sharon, Narmeen Daher-Ghanem, Deema Zaid, Michael J. Gough, Nataly Kravchenko-Balasha
Summary: Although treatment options for head and neck cancer have improved, survival rates have not increased significantly. The current treatment modalities include surgery, radiotherapy with chemotherapy, and immunotherapy. This review focuses on the effects of radiotherapy on the tumor microenvironment and the immune response, as well as the potential use of targeted therapy in combination with radiotherapy. It also emphasizes the importance of personalized treatment based on individual patients and tumor-specific factors.
FRONTIERS IN ORAL HEALTH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Thomas Duhen, Michael J. Gough, Rom S. Leidner, Sasha E. Stanton
Summary: The clinical response to cancer therapies is influenced by the complex interplay between the systemic, tumoral, and stromal immune response, as well as the direct impact of treatments on cancer cells. Differences in immunological and cancer histories, as well as variations in carcinogen exposures, can lead to variability in pre-existing immune responses, resulting in different individual responses to identical therapies. This review discusses the development of the immune environment in tumors, the crucial immune cell populations in advanced cancers, and how immune interventions can improve therapeutic outcomes in patients with pre-malignancies or advanced cancers.
FRONTIERS IN ORAL HEALTH
(2022)
Meeting Abstract
Immunology
Michael J. Gough, Tiffany Blair, Alexa K. Dowdell, Shelly Bambina, Gwen Kramer, Brian D. Piening, Marka R. Crittenden
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Michael J. Gough, Gwen Kramer, Shelly Bambina, Alejandro Alice, Tiffany Blair, Thomas Duhen, Rebekka Duhen, Marka R. Crittenden
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Andrew J. Gunderson, Venkatesh Rajamanickam, Cynthia Bui, Brady Bernard, Joanna Pucilowska, Carmen Ballesteros-Merino, Mark Schmidt, Kayla McCarty, Michaela Philips, Brian Piening, Christopher Dubay, Terry Medler, Phillipa Newell, Paul Hansen, Eric Tran, Ephraim Tang, Carlo Bifulco, Marka Crittenden, Michael Gough, Kristina H. Young
Summary: PDAC tumors show T cell inflamed phenotypes, with some tumors having early-stage TLS which correlates with higher survival rates.
