Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a single-arm, phase 2 trial

PD-1 blockade alone for mismatch repair deficient (dMMR) locally advanced rectal cancer.

(2022) Melissa Amy Lumish et al.   JOURNAL OF CLINICAL ONCOLOGY

Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy

(2022) Julio Garcia-Aguilar et al.   JOURNAL OF CLINICAL ONCOLOGY

NRG-GI002: A phase II clinical trial platform using total neoadjuvant therapy (TNT) in locally advanced rectal cancer (LARC)—Pembrolizumab experimental arm (EA) primary results.

(2021) Osama E. Rahma et al.   JOURNAL OF CLINICAL ONCOLOGY

Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?

(2021) Israa Imam et al.   RADIOTHERAPY AND ONCOLOGY

Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

(2021) Osama E. Rahma et al.   JAMA Oncology

Patient-Reported Bowel Function in Patients with Rectal Cancer Managed by a Watch-and-Wait Strategy after Neoadjuvant Therapy

(2020) Felipe F. Quezada-Diaz et al.   DISEASES OF THE COLON & RECTUM

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

(2020) Andrew J. Gunderson et al.   Nature Communications

Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12

(2019) Emmanouil Fokas et al.   JOURNAL OF CLINICAL ONCOLOGY

Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy

(2018) Ariel E. Marciscano et al.   CLINICAL CANCER RESEARCH

Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study

(2018) Maxime J M van der Valk et al.   LANCET

Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

(2018) Andrea Cercek et al.   JAMA Oncology

Implementation and Validation of an Automated Flow Cytometry Analysis Pipeline for Human Immune Profiling

(2018) Valerie K. Conrad et al.   CYTOMETRY PART A

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients

(2017) Kilian Wistuba-Hamprecht et al.   EUROPEAN JOURNAL OF CANCER

The Impact of Pathologic Complete Response in Patients with Neoadjuvantly Treated Locally Advanced Rectal Cancer—a Large Single-Center Experience

(2017) A.M. Dinaux et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma

(2016) Todd Crocenzi et al.   Journal for ImmunoTherapy of Cancer

Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management

(2015) J. Joshua Smith et al.   BMC CANCER

Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial

(2015) Julio Garcia-Aguilar et al.   LANCET ONCOLOGY

Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer

(2014) M.-G. Anitei et al.   CLINICAL CANCER RESEARCH

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years

(2012) Rolf Sauer et al.   JOURNAL OF CLINICAL ONCOLOGY

Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial

(2012) Claus Rödel et al.   LANCET ONCOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY