Immune Vulnerability of Infants to Tuberculosis

Evidence That Androgens Modulate Human Thymic T Cell Output

(2016) Nancy J. Olsen et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Interleukin-10 Promotes Mycobacterium tuberculosis Disease Progression in CBA/J Mice

(2014) G. L. Beamer et al.   JOURNAL OF IMMUNOLOGY

Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation

(2014) N. S. Joshi et al.   JOURNAL OF IMMUNOLOGY

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

Longitudinal Changes in CD4+ T-Cell Memory Responses Induced by BCG Vaccination of Newborns

(2013) Andreia P. Soares, Cheong K. C. Kwong Chung, Terry Choice, E. Jane Hughes, Gail Jacobs, Esme Janse van Rensburg, Gloria Khomba, Marwou de Kock, Lesedi Lerumo, Lebohang Makhethe, Mbulelo H. Maneli, Bernadette Pienaar, Erica Smit, Nontobeko G. Tena-Coki, Leandre van Wyk, W. Henry Boom et al.   JOURNAL OF INFECTIOUS DISEASES

Microbiota and dietary interactions - an update to the hygiene hypothesis?

(2012) R. Frei et al.   ALLERGY

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells

(2012) Robert Blomgran et al.   Cell Host & Microbe

Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages

(2012) Chao-Tsung Yang et al.   Cell Host & Microbe

Efferocytosis Is an Innate Antibacterial Mechanism

(2012) Constance J. Martin et al.   Cell Host & Microbe

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

High tuberculosis exposure among neonates in a high tuberculosis and human immunodeficiency virus burden setting

(2012) A. Bekker et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

CD4+ T Cell-Dependent IFN-  Production by CD8+ Effector T Cells in Mycobacterium tuberculosis Infection

(2012) T. D. Bold et al.   JOURNAL OF IMMUNOLOGY

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

Tuberculosis in Children

(2012) Carlos M. Perez-Velez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of Drug Resistance on Clinical Outcome in Children With Tuberculous Meningitis

(2012) James A. Seddon et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The Human Microbiome and Its Potential Importance to Pediatrics

(2012) C. L. Johnson et al.   PEDIATRICS

Ontogeny of Toll-Like and NOD-Like Receptor-Mediated Innate Immune Responses in Papua New Guinean Infants

(2012) Joanne G. Lisciandro et al.   PLoS One

The Application of Ecological Theory Toward an Understanding of the Human Microbiome

(2012) E. K. Costello et al.   SCIENCE

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Tuberculosis Pathogenesis and Immunity

(2011) Jennifer A. Philips et al.   Annual Review of Pathology-Mechanisms of Disease

Innate Immune Recognition ofMycobacterium tuberculosis

(2011) Johanneke Kleinnijenhuis et al.   Clinical & Developmental Immunology

Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17

(2011) Lara S. Dungan et al.   CYTOKINE

Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection

(2011) Katrin D. Mayer-Barber et al.   IMMUNITY

For better or for worse: the immune response against Mycobacterium tuberculosis balances pathology and protection

(2011) Anca Dorhoi et al.   IMMUNOLOGICAL REVIEWS

Lung Neutrophils Facilitate Activation of Naive Antigen-Specific CD4+ T Cells during Mycobacterium tuberculosis Infection

(2011) R. Blomgran et al.   JOURNAL OF IMMUNOLOGY

Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?

(2011) Peter Aaby et al.   JOURNAL OF INFECTIOUS DISEASES

Protein tyrosine kinase 7: a novel surface marker for human recent thymic emigrants with potential clinical utility

(2011) D B Lewis et al.   Journal of Perinatology

Macrophages and control of granulomatous inflammation in tuberculosis

(2011) J L Flynn et al.   Mucosal Immunology

Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis

(2011) S M Behar et al.   Mucosal Immunology

Initiation and regulation of T-cell responses in tuberculosis

(2011) K B Urdahl et al.   Mucosal Immunology

Role of innate cytokines in mycobacterial infection

(2011) A M Cooper et al.   Mucosal Immunology

Challenges in infant immunity: implications for responses to infection and vaccines

(2011) Mercy PrabhuDas et al.   NATURE IMMUNOLOGY

Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants

(2011) Sarah Burl et al.   PLoS One

CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input

(2011) Y. Kumamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils in tuberculosis: friend or foe?

(2011) David M. Lowe et al.   TRENDS IN IMMUNOLOGY

A Gamma Interferon Independent Mechanism of CD4 T Cell Mediated Control of M. tuberculosis Infection in vivo

(2011) Alena M. Gallegos et al.   PLoS Pathogens

Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guérin Vaccination of Newborns

(2010) Benjamin M. N. Kagina et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?

(2010) Alexandre Alcaïs et al.   Annals of the New York Academy of Sciences

Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage

(2010) D. W. Hendricks et al.   BLOOD

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions

(2010) Kerry J. Welsh et al.   Clinical & Developmental Immunology

Kinetics and cellular sources of cathelicidin during the course of experimental latent tuberculous infection and progressive pulmonary tuberculosis

(2010) J. Castañeda-Delgado et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

HIV Infection–Related Tuberculosis: Clinical Manifestations and Treatment

(2010) Timothy R. Sterling et al.   CLINICAL INFECTIOUS DISEASES

Progressive primary pulmonary tuberculosis presenting as the sudden unexpected death in infancy: A case report

(2010) Johan Dempers et al.   FORENSIC SCIENCE INTERNATIONAL

Neonatal CD8+ T-cell differentiation is dependent on interleukin-12

(2010) Mark J. McCarron et al.   HUMAN IMMUNOLOGY

From Vaccines to Memory and Back

(2010) Federica Sallusto et al.   IMMUNITY

Future Vaccination Strategies against Tuberculosis: Thinking outside the Box

(2010) Stefan H.E. Kaufmann   IMMUNITY

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis

(2010) Shahin Shafiani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

"Default" Generation of Neonatal Regulatory T Cells

(2010) G. Wang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Caspase-1 Independent IL-1  Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

(2010) K. D. Mayer-Barber et al.   JOURNAL OF IMMUNOLOGY

Innate immunity in human newborn infants: prematurity means more than immaturity

(2010) Tobias Strunk et al.   Journal of Maternal-Fetal & Neonatal Medicine

Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis

(2010) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?

(2010) Samuel M. Behar et al.   NATURE REVIEWS MICROBIOLOGY

Acquisition of Adult-Like TLR4 and TLR9 Responses during the First Year of Life

(2010) Muriel Nguyen et al.   PLoS One

Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of Human Blood Mononuclear Cells

(2010) Nathan P. Corbett et al.   PLoS One

Tuberculosis at extremes of age

(2010) H. Simon SCHAAF et al.   RESPIROLOGY

Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans

(2010) J. E. Mold et al.   SCIENCE

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

The role of CD4 T cell help for CD8 CTL activation

(2009) Sheng Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants

(2009) S. J. Opiela et al.   BLOOD

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

(2009) Seok-Yong Eum et al.   CHEST

Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life

(2009) M.E. Belderbos et al.   CLINICAL IMMUNOLOGY

Neonatal innate immunity in allergy development

(2009) Mirjam Belderbos et al.   CURRENT OPINION IN PEDIATRICS

Human CD4+T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function

(2009) Christopher J. Haines et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY

Multiplex Analysis of Toll-Like Receptor-Stimulated Neonatal Cytokine Response

(2009) Justin E. Caron et al.   Neonatology

Susceptibility to Mycobacterial Infections in Children With X-Linked Chronic Granulomatous Disease

(2009) Pamela P. W. Lee et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Twenty Years of Pediatric Tuberculous Meningitis: A Retrospective Cohort Study in the Western Cape of South Africa

(2009) G. T. J. van Well et al.   PEDIATRICS

Postthymic maturation influences the CD8 T cell response to antigen

(2009) L. E. Makaroff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells

(2009) Habib Zaghouani et al.   TRENDS IN IMMUNOLOGY

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection

(2009) David M. Higgins et al.   TUBERCULOSIS

Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response

(2009) Benjamin M.N. Kagina et al.   VACCINE

Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance

(2008) Jean Pieters   Cell Host & Microbe

Containment of aerogenicMycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9

(2008) Christoph Hölscher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Illuminating the Black Box of TNF Action in Tuberculous Granulomas

(2008) Elizabeth A. Miller et al.   IMMUNITY

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The outcome of infants younger than 6 months requiring ventilation for pneumonia caused byMycobacterium tuberculosis

(2008) P. Goussard et al.   PEDIATRIC PULMONOLOGY

Whole Blood Interferon-Gamma Responses to Mycobacterium tuberculosis Antigens in Young Household Contacts of Persons with Tuberculosis in Uganda

(2008) Deborah A. Lewinsohn et al.   PLoS One

ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes

(2008) W. W. Reiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence

(2008) Niladri Ganguly et al.   TUBERCULOSIS