For better or for worse: the immune response against Mycobacterium tuberculosis balances pathology and protection

Decreased Pathology and Prolonged Survival of Human DC-SIGN Transgenic Mice during Mycobacterial Infection

(2014) M. Schaefer et al.   JOURNAL OF IMMUNOLOGY

IL-15 Links TLR2/1-Induced Macrophage Differentiation to the Vitamin D-Dependent Antimicrobial Pathway

(2014) S. R. Krutzik et al.   JOURNAL OF IMMUNOLOGY

NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity

(2014) M. Divangahi et al.   JOURNAL OF IMMUNOLOGY

Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis

(2014) J. O. Jurado et al.   JOURNAL OF IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

(2010) Bibhuti B. Mishra et al.   CELLULAR MICROBIOLOGY

Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis

(2010) Tracey A. Day et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung

(2010) Paul S. Redford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

(2010) Stephen T. Reece et al.   JOURNAL OF CLINICAL INVESTIGATION

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection withMycobacterium tuberculosis

(2010) Andrea Cruz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis

(2010) Shahin Shafiani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Partial Redundancy of the Pattern Recognition Receptors, Scavenger Receptors, and C-Type Lectins for the Long-Term Control of Mycobacterium tuberculosis Infection

(2010) N. Court et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Caspase-1 Independent IL-1  Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

(2010) K. D. Mayer-Barber et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1

(2010) F. L. van de Veerdonk et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis

(2010) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection

(2010) Fredric Carlsson et al.   PLoS Pathogens

Initiation of Acquired Immunity in the Lungs of Mice Lacking Lymph Nodes after Infection with Aerosolized Mycobacterium tuberculosis

(2009) Suely S. Kashino et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

Hypoxia: a window intoMycobacterium tuberculosislatency

(2009) Tige R. Rustad et al.   CELLULAR MICROBIOLOGY

Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

(2009) Seok-Yong Eum et al.   CHEST

Immunogenicity of Novel DosR Regulon-Encoded Candidate Antigens of Mycobacterium tuberculosis in Three High-Burden Populations in Africa

(2009) G. F. Black et al.   Clinical and Vaccine Immunology

Fine-tuning of T cell responses during infection

(2009) Anca Dorhoi et al.   CURRENT OPINION IN IMMUNOLOGY

Interferon-γ-Responsive Nonhematopoietic Cells Regulate the Immune Response to Mycobacterium tuberculosis

(2009) Ludovic Desvignes et al.   IMMUNITY

The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages

(2009) T. Kurenuma et al.   INFECTION AND IMMUNITY

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

A murine DC-SIGN homologue contributes to early host defense againstMycobacterium tuberculosis

(2009) Antoine Tanne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combination of Host Susceptibility and Virulence ofMycobacterium tuberculosisDetermines Dual Role of Nitric Oxide in the Protection and Control of Inflammation

(2009) Martin Beisiegel et al.   JOURNAL OF INFECTIOUS DISEASES

Differences in the Ability to Generate Type 1 T Helper Cells Need Not Determine Differences in the Ability to ResistMycobacterium tuberculosisInfection among Mouse Strains

(2009) Yu‐Jin Jung et al.   JOURNAL OF INFECTIOUS DISEASES

The resuscitation-promoting factors ofMycobacterium tuberculosisare required for virulence and resuscitation from dormancy but are collectively dispensable for growthin vitro

(2009) Bavesh D. Kana et al.   MOLECULAR MICROBIOLOGY

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

(2009) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Identification of T-Cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection

(2009) Sebastian D. Schuck et al.   PLoS One

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens

(2009) Igor E. Brodsky et al.   SEMINARS IN IMMUNOLOGY

High granulocyte/lymphocyte ratio and paucity of NKT cells defines TB disease in a TB-endemic setting

(2009) Jayne S. Sutherland et al.   TUBERCULOSIS

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Mycobacterium tuberculosis Prevents Inflammasome Activation

(2008) Sharon S. Master et al.   Cell Host & Microbe

ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection

(2008) Ingrid C. Koo et al.   CELLULAR MICROBIOLOGY

Role of C-Type Lectins in Mycobacterial Infections

(2008) L. Schlesinger et al.   CURRENT DRUG TARGETS

Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs

(2008) Eun-Kyeong Jo   CURRENT OPINION IN INFECTIOUS DISEASES

Containment of aerogenicMycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9

(2008) Christoph Hölscher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MyDths and un-TOLLed truths: Sensor, instructive and effector immunity to tuberculosis

(2008) Norbert Reiling et al.   IMMUNOLOGY LETTERS

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

(2008) Franca Gerosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metronidazole Lacks Activity againstMycobacterium tuberculosisin an In Vivo Hypoxic Granuloma Model of Latency

(2008) Lee G. Klinkenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence

(2008) Huixian Gan et al.   NATURE IMMUNOLOGY

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE