Article
Cardiac & Cardiovascular Systems
Reza Mohebi, Yuxi Liu, Roland van Kimmenade, Hanna K. Gaggin, Sean P. Murphy, James L. Januzzi Jr
Summary: The study aimed to investigate the association between inflammatory biomarkers and incident heart failure events in patients at different stages of HF. Using machine learning, the levels of inflammation were categorized into low, medium, and high groups. Higher concentrations of natriuretic peptide, troponin, and soluble ST2 were observed in the high inflammation group. The incidence of HF hospitalization varied across different stages, with higher inflammation levels associated with higher risks.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, Research & Experimental
Jordana Kron, Thomas Crawford, Virginia Mihalick, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Shilpa Jasti, Lynda Rosenfeld, David Birnie, Melissa Smallfield, Le Kang, Alpha Berry Fowler, Amy Ladd, Kenneth Ellenbogen, Benjamin Van Tassell, W. Gregory Hundley, Antonio Abbate
Summary: Cardiac sarcoidosis is a rare disease that can lead to life-threatening complications, and this trial aims to investigate the effectiveness of IL-1 blockade with anakinra in combating systemic and cardiac inflammation in patients with this condition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossu
Summary: Homotaurine is a potential therapeutic compound for Alzheimer's disease (AD) and has anti-inflammatory properties. This study suggests that supplementation of homotaurine in patients with mild cognitive impairment (MCI) increases the levels of anti-inflammatory cytokines IL-10 and IL-33, while decreasing the levels of pro-inflammatory cytokine IL-18. The elevation of IL-10 and IL-33 is associated with improved episodic memory in treated patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Punniyakoti Veeraveedu Thanikachalam, Srinivasan Ramamurthy, Poojitha Mallapu, Sudhir Rama Varma, Jayaraj Narayanan, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: IL-33 is a cytokine that belongs to the IL-1 family and promotes the production of Th2 cytokines by binding with ST2L and IL-1RAcP. It has demonstrated protective effects against cardiovascular diseases by inducing Th2 cytokines and promoting alternative activating M2 polarization. However, the soluble decoy form of ST2 mitigates its effects, exacerbating cardiovascular diseases. IL-33 also plays a significant role in the development of asthma, arthritis, atopic dermatitis, and anaphylaxis. This review aims to explore the protective role of IL-33 against cardiovascular diseases and the potential of serum soluble ST2 as a diagnostic biomarker for these diseases. Therefore, IL-33 holds promise as a potential therapeutic target for cardiovascular diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Walter J. Paulus, Michael R. Zile
Summary: According to the comorbidity-inflammation paradigm, comorbidities, especially metabolic ones, are believed to drive the development and severity of heart failure with preserved ejection fraction. Recent evidence includes myocardial infiltration, inducible nitric oxide synthase expression, patient phenogroups, and direct connections between comorbidities, inflammatory biomarkers, and abnormal myocardial structure/function.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Wesley Tyler Abplanalp, Sebastian Cremer, David John, Jedrzej Hoffmann, Bianca Schuhmacher, Maximillian Merten, Michael A. Rieger, Mariuca Vasa-Nicotera, Andreas M. Zeiher, Stefanie Dimmeler
Summary: This study reveals that circulating monocytes and T cells of patients with heart failure harboring clonal hematopoiesis-driver mutations in DNMT3A exhibit a highly inflamed transcriptome, which may contribute to the aggravation of chronic heart failure.
CIRCULATION RESEARCH
(2021)
Review
Medicine, General & Internal
Elias Rawish, Thomas Stiermaier, Francesco Santoro, Natale D. Brunetti, Ingo Eitel
Summary: Takotsubo syndrome (TTS) is an acute cardiac condition that mimics acute myocardial infarction, characterized by temporary left ventricular dysfunction. Coronary angiography with left ventriculography is the gold standard diagnostic tool for excluding or confirming TTS. TTS is often associated with severe emotional or physical stress, and further research is needed to understand the underlying pathophysiological mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio Abbate, George F. Wohlford, Marco Giuseppe Del Buono, Juan Guido Chiabrando, Roshanak Markley, Jeremy Turlington, Dinesh Kadariya, Cory R. Trankle, Giuseppe Biondi-Zoccai, Michael J. Lipinski, Benjamin W. Van Tassell
Summary: This study suggests that treatment with Anakinra for 14 days can lower the incidence of new-onset HF or hospitalization for HF in patients with STEMI.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Oncology
Aftab Alam, Eric Levanduski, Parker Denz, Helena Solleiro Villavicencio, Maulasri Bhatta, Lamees Alhorebi, Yali Zhang, Eduardo Cortes Gomez, Brian Morreale, Sharon Senchanthisai, Jun Li, Steven G. Turowski, Sandra Sexton, Sheila Jani Sait, Prashant K. Singh, Jianmin Wang, Anirban Maitra, Pawel Kalinski, Ronald A. DePinho, Huamin Wang, Wenting Liao, Scott I. Abrams, Brahm H. Segal, Prasenjit Dey
Summary: TH2 cells and ILC2 cells stimulate tumor growth by secreting pro-tumorigenic cytokines. Oncogenic Kras(G12D) increases IL-33 expression in PDAC cells, recruiting and activating TH2 and ILC2 cells. Cancer-cell-specific deletion of IL-33 reduces TH2 and ILC2 recruitment and promotes tumor regression.
Review
Biochemistry & Molecular Biology
Leticia Gonzalez, Katherine Rivera, Marcelo E. Andia, Gonzalo Martinez Rodriguez
Summary: The IL-1 superfamily of cytokines, consisting of 11 cytokines and 10 receptors, is a crucial regulator of immunity and inflammation. It is tightly regulated through decoy receptor, receptor antagonists, and signaling inhibitors. Inflammation plays a central role in the development of atherosclerosis, and studies have shown the involvement of IL-1 cytokines and receptors in cardiovascular disease pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Gaidaa M. Dogheim, Mohamed T. Amralla, Rehab H. Werida
Summary: Inflammation plays a crucial role in the development of heart failure, and neopterin, an inflammatory biomarker, can be used for diagnosing HF, determining disease severity, and monitoring disease progression.
INFLAMMOPHARMACOLOGY
(2022)
Article
Rheumatology
Micol Romano, Z. Serap Arici, David Piskin, Sara Alehashemi, Daniel Aletaha, Karyl S. Barron, Susanne Benseler, Roberta Berard, Lori Broderick, Fatma Dedeoglu, Michelle Diebold, Karen L. Durrant, Polly Ferguson, Dirk Foell, Jonathan Hausmann, Olcay Y. Jones, Daniel L. Kastner, Helen J. Lachmann, Ronald M. Laxer, Dorelia Rivera, Nicolino Ruperto, Anna Simon, Marinka Twilt, Joost Frenkel, Hal Hoffman, Adriana A. de Jesus, Jasmin Beate Kuemmerle-Deschner, Seza Ozen, Marco Gattorno, Raphaela Goldbach-Mansky, Erkan Demirkaya
Summary: This study aims to establish evidence-based recommendations for the diagnosis, treatment, and monitoring of patients with IL-1 mediated autoinflammatory diseases in order to standardize their management. A multinational, multidisciplinary task force conducted evidence synthesis and expert consensus to provide guiding principles and statements for diagnosis, therapy, and long-term monitoring of these patients. The goal is to improve patient care, quality of life, and disease outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Immunology
Praxedis Martin, Jeremie D. Goldstein, Loic Mermoud, Alejandro Diaz-Barreiro, Gaby Palmer
Summary: IL-1 family cytokines play important roles in skin disorders, and dysregulated signaling may lead to the development of chronic inflammatory diseases. Anti-inflammatory IL-1 family members such as IL-1Ra and IL-36Ra control the biological activity of pro-inflammatory IL-1 family agonists. These cytokines are highly expressed in the epidermis and have therapeutic potential for human inflammatory skin diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
D. Kollmann, B. Nagl, C. Ebner, W. Emminger, S. Worhrl, C. Kitzmueller, S. Vrtala, A. Mangold, H-J. Ankersmit, B. Bohle
Article
Biology
Lucian Beer, Lucas Nemec, Tanja Wagner, Robin Ristl, Lukas M. Altenburger, Hendrik Jan Ankersmit, Michael Mildner
JOURNAL OF RADIATION RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Alexis Slama, Lukas Schillab, Maximilian Barta, Aris Benedek, Andreas Mitterbauer, Konrad Hoetzenecker, Shahrokh Taghavi, Gyoergy Lang, Jose Matilla, Hendrik Ankersmit, Helmut Hager, Georg Roth, Walter Klepetko, Clemens Aigner
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2017)
Article
Medical Laboratory Technology
Thomas Haider, Elisabeth Simader, Philipp Hacker, Hendrik J. Ankersmit, Thomas Heinz, Stefan Hajdu, Lukas L. Negrin
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2018)
Article
Medical Laboratory Technology
Stefan Hacker, Benjamin Dieplinger, Gregor Werba, Stefanie Nickl, Georg A. Roth, Claus G. Krenn, Thomas Mueller, Hendrik J. Ankersmit, Thomas Haider
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2018)
Article
Multidisciplinary Sciences
Bahil Ghanim, Sebastian Hess, Pietro Bertoglio, Ali Celik, Aynur Bas, Felicitas Oberndorfer, Franca Melfi, Alfredo Mussi, Walter Klepetko, Christine Pirker, Walter Berger, Imrich Harmati, Attila Farkas, Hendrik Jan Ankersmit, Balazs Dome, Janos Fillinger, Clemens Aigner, Balazs Hegedus, Ferenc Renyi-Vamos, Gyoergy Lang
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Tanja Wagner, Denise Traxler, Elisabeth Simader, Lucian Beer, Marie-Sophie Narzt, Florian Gruber, Sibylle Madlener, Maria Laggner, Michael Erb, Vera Vorstandlechner, Alfred Gugerell, Christine Radtke, Massimiliano Gnecchi, Anja Peterbauer, Maria Gschwandtner, Erwin Tschachler, Claudia Keibl, Paul Slezak, Hendrik J. Ankersmit, Michael Mildner
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Silvio Wuschko, Alfred Gugerell, Monika Chabicovsky, Helmut Hofbauer, Maria Laggner, Michael Erb, Tobias Ostler, Anja Peterbauer, Susanne Suessner, Svitlana Demyanets, Jost Leuschner, Bernhard Moser, Michael Mildner, Hendrik J. Ankersmit
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Matthias Zimmermann, Denise Traxler, Christine Bekos, Elisabeth Simader, Thomas Mueller, Alexandra Graf, Mitja Lainscak, Robert Marcun, Mitja Kosnik, Matjaz Flezar, Ales Rozman, Peter Korosec, Walter Klepetko, Bernhard Moser, Hendrik J. Ankersmit
CELL STRESS & CHAPERONES
(2020)
Review
Dentistry, Oral Surgery & Medicine
Matthias Zimmermann, Emeka Nkenke
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2020)
Article
Biochemistry & Molecular Biology
Layla Panahipour, Evgeniya Kochergina, Maria Laggner, Matthias Zimmermann, Michael Mildner, Hendrik J. Ankersmit, Reinhard Gruber
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biology
Caterina Selina Mildner, Dragan Copic, Matthias Zimmermann, Michael Lichtenauer, Martin Direder, Katharina Klas, Daniel Bormann, Alfred Gugerell, Bernhard Moser, Konrad Hoetzenecker, Lucian Beer, Mariann Gyoengyoesi, Hendrik Jan Ankersmit, Maria Laggner
Summary: Acute myocardial infarction results in impaired coronary blood flow and compromised heart function. Therapeutic secretome of stressed white blood cells improved heart function in a porcine infarction model by promoting tissue regeneration and impacting metabolic processes in distal organs. This study suggests potential pharmacologic strategies to limit adverse cardiac remodeling and sequelae after myocardial infarction.
Article
Hematology
Alfred Gugerell, Dirk Sorgenfrey, Maria Laggner, Juergen Raimann, Anja Peterbauer, Daniel Bormann, Susanne Suessner, Christian Gabriel, Bernhard Moser, Tobias Ostler, Michael Mildner, Hendrik J. Ankersmit
Article
Multidisciplinary Sciences
Christine Bekos, Matthias Zimmermann, Lukas Unger, Stefan Janik, Andreas Mitterbauer, Michael Koller, Robert Fritz, Christian Gaebler, Jessica Didcock, Jonathan Kliman, Walter Klepetko, Hendrik Jan Ankersmit, Bernhard Moser
SCIENTIFIC REPORTS
(2019)
Article
Medical Laboratory Technology
Denise Traxler, Mitja Lainscak, Elisabeth Simader, Hendrik Jan Ankersmit, Borut Jug
CLINICA CHIMICA ACTA
(2017)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)
