Article
Endocrinology & Metabolism
Wenqiang Li, Tong Liu, Liang Qian, Yiming Wang, Xiangming Ma, Liying Cao, Qingsong Zhang, Jun Qu
Summary: This study found that the association between abdominal obesity and colorectal cancer risk may be mediated by factors such as insulin resistance and inflammation. General and abdominal obesity were associated with an increased risk of colorectal cancer in males, while only abdominal obesity was associated with an increased risk in females. Additionally, the mediation effects of fasting triglyceride-glucose index and C-reactive protein were observed for the association between abdominal obesity and colorectal cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Karen E. Elkind-Hirsch, Neil Chappell, Donna Shaler, John Storment, Drake Bellanger
Summary: This study aimed to evaluate the efficacy and safety of the GLP-1 analog liraglutide 3 mg (LIRA 3 mg) in reducing body weight and hyperandrogenism in women with obesity and polycystic ovary syndrome (PCOS). The results showed that LIRA 3 mg was superior to placebo in reducing body weight, lowering androgen levels, and improving cardiometabolic parameters.
FERTILITY AND STERILITY
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Ben Kirk, Kate Mooney, Sara Vogrin, Matthew Jackson, Gustavo Duque, Omid Khaiyat, Farzad Amirabdollahian
Summary: The study investigated the effects of 16 weeks of leucine-enriched whey protein supplementation and resistance-based exercise on cardiometabolic health markers in older adults. The results showed that supplementing protein could improve LDL cholesterol levels, lower insulin and HOMA-IR levels, and be beneficial to the health of older adults.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Health Care Sciences & Services
Nourhen Mezghani, Achraf Ammar, Omar Boukhris, Rihab Abid, Atyh Hadadi, Turki Mohsen Alzahrani, Omar Trabelsi, Mohamed Ali Boujelbane, Liwa Masmoudi, Ibrahim Ouergui, Kamel Jamoussi, Mouna Mnif, Hafedh Mejdoub, Piotr Zmijewski, Jordan M. Glenn, Khaled Trabelsi, Hamdi Chtourou
Summary: The study found that three different training intensities have benefits in terms of body composition, physiological and muscular adaptations, and insulin resistance. High training intensity leads to greater improvements in body mass, BMI, and endurance and strength, while moderate training intensity results in greater improvements in insulin resistance and Homa-IR. Following alternate-intensity training, greater improvements were observed in lean mass and maximal strength performance.
Article
Medicine, General & Internal
Jose Ignacio Ramirez-Manent, Angel Arturo Lopez-Gonzalez, Pilar Tomas-Gil, Pere Riutord-Sbert, Lucia Garrido-Sepulveda, Maria Teofila Vicente-Herrero
Summary: This study examines the relationship between two obesity assessment methods based on hip circumference and metabolic syndrome (MetS) and insulin resistance risk scales. The results show that AVI demonstrates higher predictive value for MetS, while AVI and BAI mainly show predictive value for high insulin resistance risk scales in the case of METS-IR, with higher predictive value in women.
Article
Clinical Neurology
Berta Portugal, Fanny Artaud, Cloe Domenighetti, Emmanuel Roze, Isabelle Degaey, Marianne Canonico, Alexis Elbaz
Summary: This study found an inverse association between obesity and Parkinson's disease in a cohort of French women. The occurrence of obesity was less frequent in patients with PD before diagnosis, indicating a potential protective effect of obesity in the development of PD.
Article
Cell Biology
Tim K. Bosslau, Paulina Wasserfurth, Britta Kruger, Thomas Reichel, Jana Palmowski, Josefine Nebl, Christopher Weyh, Alexander Schenk, Niklas Joisten, Frank Stahl, Stefanie Thoms, Kristina Gebhardt, Andreas Hahn, Karsten Kruger
Summary: Aging and overweight increase the risk of developing type 2 diabetes mellitus, and this study suggests that CD8+EMRA cells may play a mediating role in glucose metabolism in elderly individuals, with abdominal obesity potentially impacting insulin resistance through CD8+EMRA cells.
Article
Biochemistry & Molecular Biology
Gabriela Krejcova, Cecilia Morgantini, Helena Zemanova, Volker M. Lauschke, Julie Kovarova, Jiri Kubasek, Pavla Nedbalova, Nick Kamps-Hughes, Martin Moos, Myriam Aouadi, Tomas Dolezal, Adam Bajgar
Summary: The immune response and systemic metabolic changes are closely connected. The production of ImpL2/IGFBP7 by macrophages plays a critical role in regulating insulin signaling and mobilizing lipoproteins. This mechanism is conserved in both Drosophila and mammals.
Review
Cardiac & Cardiovascular Systems
Belen Picatoste, Isabel Cerro-Pardo, Luis M. Blanco-Colio, Jose L. Martin-Ventura
Summary: This review discusses the impact of diabetes mellitus (DM) on abdominal aortic aneurysms (AAA). It suggests that DM may have a protective role, potentially through factors such as hyperglycemia or insulin resistance, as well as through the effect of prescribed DM drugs. The review also summarizes the potential cellular and molecular pathways involved in the vascular effects of DM and provides an overview of current antidiabetic therapies that could be beneficial for AAA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Pierluigi Moccia, Rocio Belda-Montesinos, Aitana Monllor-Tormos, Peter Chedraui, Antonio Cano
Summary: The menopausal transition is associated with an increase in adiposity, particularly in the abdominal area, and a decrease in lean mass. Changes in energy expenditure and food intake also play a role, with the estrogen receptor alpha isoform being a key factor in fat accrual. Additional hormonal factors, including androgens and FSH, may also contribute to changes in body composition during menopause.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Rasmus Fuglsang-Nielsen, Elin Rakvaag, Peter Vestergaard, Kjeld Hermansen, Soren Gregersen, Jakob Starup-Linde
Summary: This study aimed to investigate the effect of increased protein intake on bone turnover in individuals with abdominal obesity. The results showed that 12 weeks of increased whey protein intake did not significantly affect bone turnover markers, although there was a tendency to increase parathyroid hormone levels. Dietary fiber intake did not impact bone turnover. The study also found a positive association between insulin resistance and parathyroid hormone changes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Thomas M. Barber, Stefan Kabisch, Harpal S. Randeva, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: Resveratrol, a polyphenol chemical found in many plant-based dietary products, has potential health benefits. After ingestion, it undergoes extensive metabolism, inhibits adipogenesis and fat accumulation, possesses anti-inflammatory effects, and may improve insulin sensitivity and inflammatory status. However, optimal dosage and benefits within the general population need further research.
Article
Biochemistry & Molecular Biology
Luciane de L. Teixeira, Genevieve Pilon, Camille Perella Coutinho, Stephanie Dudonne, Pascal Dube, Vanessa Houde, Yves Desjardins, Franco M. Lajolo, Andre Marette, Neuza M. A. Hassimotto
Summary: The study found that the polyphenolic extract from purple grumixama has significant effects on reducing obesity and improving insulin resistance, leading to decreased body weight gain, improved insulin sensitivity, and reduced hepatic fat accumulation.
Article
Cardiac & Cardiovascular Systems
Grith Moller, Christian Ritz, Louise Kjolbaek, Stine Vuholm, Sanne Kellebjerg Korndal, Thomas Meinert Larsen, Oluf Pedersen, Wim Saris, Arne Astrup, Lotte Lauritzen, Mette Kristensen, Mads Vendelbo Lind
Summary: This study found differences in the correlations between body mass index (BMI) and waist circumference (WC) with sagittal abdominal diameter (SAD) in relation to cardiometabolic risk markers. Overall, SAD showed a stronger correlation with triglycerides (TG) and diastolic blood pressure (DBP) compared to WC, and a stronger correlation with TG and DBP compared to BMI in most studies.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cell Biology
Tamara Mazo, Veronica D'Annunzio, Tamara Zaobornyj, Virginia Perez, Anabella Gomez, Gabriela Berg, Magali Barchuk, Georgina Ossani, Manuela Martinefski, Valeria Tripodi, Nestor Lago, Ricardo J. Gelpi
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Pathology
Pablo Cassaglia, Federico Penas, Celeste Betazza, Florencia Fontana Estevez, Veronica Miksztowicz, Nadia Martinez Naya, Maria Clara Llamosas, Sofia Noli Truant, Luciana Wilensky, Veronica Volberg, Agata C. Cevey, Vanessa Touceda, Eliana Cicale, Gabriela Berg, Marisa Fernandez, Nora Goren, Celina Morales, German E. Gonzalez
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Article
Hematology
Magali Barchuk, Anne Dutour, Patricia Ancel, Ljubica Svilar, Veronica Miksztowicz, Graciela Lopez, Miguel Rubio, Laura Schreier, Juan Patricio Nogueira, Rene Valero, Sophie Beliard, Jean Charles Martin, Gabriela Berg, Benedicte Gaborit
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Peripheral Vascular Disease
Julieta S. Del Mauro, Paula D. Prince, Yanina Santander Plantamura, Miguel A. Allo, Luciano Parola, Nahuel Fernandez Machulsky, Marcela A. Moretton, Eliana P. Bin, German E. Gonzalez, Facundo M. Bertera, Andrea Carranza, Gabriela Berg, Carlos A. Taira, Martin Donato, Diego A. Chiappetta, Ariel H. Polizio, Christian Hocht
Summary: By comparing the effects of nebivolol and atenolol on hypertensive rats, it was found that nebivolol was more effective in reducing central systolic blood pressure and blood pressure variability, as well as providing greater protection against target organ damage.
HYPERTENSION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Carolina Ibar, Federico Fortuna, Diego Gonzalez, Juan Jamardo, Dario Jacobsen, Lucas Pugliese, Laura Giraudo, Veronica Ceres, Cynthia Mendoza, Esteban M. Repetto, Graciela Reboredo, Silvia Iglesias, Sergio Azzara, Gabriela Berg, Damian Zopatti, Bibiana Fabre
Summary: In the context of the COVID-19 pandemic, healthcare workers are facing higher levels of stress and burnout, with 40% of them having hair cortisol values outside of the healthy reference range. There is a direct correlation between hair cortisol concentration, perceived stress, and the emotional exhaustion component of burnout among healthcare workers.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Tatiana Sadalla Collese, Augusto Cesar F. De Moraes, Tara Rendo-Urteaga, Laura I. Gonzalez-Zapata, Diego Alejandro Gaitan Charry, Carlos A. Delgado, Gabriela Berg, Francisco Leonardo Torres-Leal, Heraclito B. Carvalho
Summary: This study evaluated the validity of a food frequency questionnaire (FFQ) and 24-hour dietary recalls (24h-DR) for assessing dietary iron intake in South American children and adolescents. The results showed that the FFQ had good correlations and agreements in both age groups, indicating its effectiveness in ranking total dietary iron intake. The study received a score of 8 out of 10 for its importance.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2022)
Article
Nutrition & Dietetics
Marcus Vinicius Nascimento-Ferreira, Gabriela Berg, Laura Ines Gonzalez Zapata, Augusto Cesar Ferreira De Moraes, Heraclito Barbosa Carvalho
Summary: The study aimed to develop and validate risk scores for predicting abdominal obesity in South American children and adolescents. The results showed that risk scores A and B in adolescents have acceptable performance in identifying those at risk of abdominal obesity.
CLINICAL NUTRITION ESPEN
(2021)
Article
Psychology, Developmental
Natalia Carro, Carolina Ibar, Paola D'Adamo, Diego Gonzalez, Gabriela Berg, Bibiana Fabre, Mariana Lozada
Summary: This study found that a mindfulness-based intervention program had positive effects on reducing chronic stress and enhancing social integration in children.
CHILD CARE HEALTH AND DEVELOPMENT
(2023)
Article
Hematology
Magali Barchuk, Patricia Ancel, Veronica Miksztowicz, Elisa Doukbi, Ljubica Svilar, Daniel Ynon, Juan Patricio Nogueira, Miguel Rubio, Laura Schreier, Anne Dutour, Jean Charles Martin, Benedicte Gaborit, Gabriela Berg
Summary: This study evaluated the relationship between lipoprotein lipase (LPL) activity, its regulators, and ceramides in epicardial adipose tissue (EAT) from patients with coronary artery disease (CAD). The results showed that LPL activity was higher in EAT from CAD patients, and EAT exhibited increased ceramide levels. The findings highlight the importance of LPL activity and these bioactive lipids in the different metabolic profile of EAT in CAD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Gabriela Berg, Magali Barchuk, Martin Lobo, Juan Patricio Nogueira
Summary: This meta-analysis suggests that GLP-1 analogues therapy can significantly reduce epicardial adipose tissue (EAT) in patients with type 2 diabetes, leading to improvements in HbA1c levels, body mass index, low-density lipoprotein levels, and triglycerides levels.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Review
Obstetrics & Gynecology
Walter Masson, Leandro Barbagelata, Martin Lobo, Gabriela Berg, Augusto Lavalle-Cobo, Juan P. Nogueira
Summary: The study compared the thickening of epicardial adipose tissue (EAT) between patients with gestational diabetes mellitus (GDM) or pregnancy-related hypertensive disorders and healthy controls. The results showed that patients with GDM or pregnancy-related hypertensive disorders had increased EAT thickness.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Environmental Sciences
Livia Gabriele Azevedo-Garcia, Francisco Leonardo Torres-Leal, Juan Carlos Aristizabal, Gabriela Berg, Heraclito B. Carvalho, Augusto Cesar Ferreira De Moraes
Summary: Chronic low-grade inflammation may contribute to chronic non-communicable diseases in young populations; diet is related to chronic inflammation; the validation of the PAIFIS tool in children and adolescents showed acceptable reliability but weak validity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Medical Laboratory Technology
Magali Barchuk, Takumi Nagasawa, Masami Murakami, Graciela Lopez, Julio Baldi, Veronica Miksztowicz, Miguel Rubio, Laura Schreier, Katsuyuki Nakajima, Gabriela Berg
CLINICA CHIMICA ACTA
(2020)
Review
Biochemistry & Molecular Biology
Magali Barchuk, Laura Schreier, Gabriela Berg, Veronica Miksztowicz
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2020)
Article
Cardiac & Cardiovascular Systems
Pablo Corral, Virginia Banares, Benjamin Saenz, Valeria Zago, Agustina Sarobe, Graciela Lopez, Gabriela Berg, Laura Schreier
ARCHIVOS DE CARDIOLOGIA DE MEXICO
(2020)