Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases

The Effect of Nitrate Supplementation on Exercise Performance in Healthy Individuals: A Systematic Review and Meta-Analysis

(2016) Matthew W. Hoon et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis

(2015) Mattias Carlström et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitrite-mediated renal vasodilatation is increased during ischemic conditions via cGMP-independent signaling

(2015) Ming Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interactions between cocoa flavanols and inorganic nitrate: Additive effects on endothelial function at achievable dietary amounts

(2015) Ana Rodriguez-Mateos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism

(2015) Ting Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of hyperbaric oxygen on nitric oxide generation in humans

(2015) Johan Uusijärvi et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Pitfalls in measuring NO bioavailability using NOx

(2015) Daniel B. Kim-Shapiro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKAy mice

(2015) Kazuo Ohtake et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Circulating Nitrite Contributes to Cardioprotection by Remote Ischemic Preconditioning

(2014) Tienush Rassaf et al.   CIRCULATION RESEARCH

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects

(2014) Peter J. Rix et al.   CLINICAL PHARMACOKINETICS

Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway

(2014) Lee D. Roberts et al.   DIABETES

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

(2014) N. Siddiqi et al.   EUROPEAN HEART JOURNAL

Inorganic Nitrate Supplementation Improves Exercise Capacity in Subjects with HF with Preserved EF - A Pilot Study

(2014) Payman Zamani et al.   JOURNAL OF CARDIAC FAILURE

UVA Irradiation of Human Skin Vasodilates Arterial Vasculature and Lowers Blood Pressure Independently of Nitric Oxide Synthase

(2014) Donald Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nitrite reduction and cardiovascular protection

(2014) Sami A. Omar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart

(2014) Tom Ashmore et al.   JOURNAL OF PHYSIOLOGY-LONDON

Novel Aspects of Dietary Nitrate and Human Health

(2013) Eddie Weitzberg et al.   Annual Review of Nutrition

Experimental research Comparing the effects of inorganic nitrate and allopurinol in renovascular complications of metabolic syndrome in rats: role of nitric oxide and uric acid

(2013) Soha S. Essawy et al.   Archives of Medical Science

Beetroot juice improves in overweight and slightly obese men postprandial endothelial function after consumption of a mixed meal

(2013) Peter J. Joris et al.   ATHEROSCLEROSIS

Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity

(2013) Neill K. J. Adhikari et al.   CRITICAL CARE MEDICINE

Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes

(2013) Mark Gilchrist et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex

(2013) Shanti Velmurugan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary nitrite improves insulin signaling through GLUT4 translocation

(2013) Hong Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inorganic Nitrate and Beetroot Juice Supplementation Reduces Blood Pressure in Adults: A Systematic Review and Meta-Analysis

(2013) Mario Siervo et al.   JOURNAL OF NUTRITION

Low-Dose Sodium Nitrite Attenuates Myocardial Ischemia and Vascular Ischemia-Reperfusion Injury in Human Models

(2013) Thomas E. Ingram et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies

(2013) Ditte A. Hobbs et al.   NUTRITION RESEARCH REVIEWS

The oral microbiome and nitric oxide homoeostasis

(2013) MP Hezel et al.   ORAL DISEASES

Nitrite is a positive modulator of the Frank-Starling response in the vertebrate heart

(2012) Tommaso Angelone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature

(2012) Aurelie Nguyen Dinh Cat et al.   ANTIOXIDANTS & REDOX SIGNALING

Dietary Nitrate Ameliorates Pulmonary Hypertension

(2012) Reshma S. Baliga et al.   CIRCULATION

Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion

(2012) Thomas Nyström et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats

(2012) Lucas C. Pinheiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary inorganic nitrate mobilizes circulating angiogenic cells

(2012) Christian Heiss et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physiological role for nitrate-reducing oral bacteria in blood pressure control

(2012) Vikas Kapil et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polyphenols decreased liver NADPH oxidase activity, increased muscle mitochondrial biogenesis and decreased gastrocnemius age-dependent autophagy in aged rats

(2012) Caroline Laurent et al.   FREE RADICAL RESEARCH

Biology of nitrogen oxides in the gastrointestinal tract

(2012) Jon O Lundberg et al.   GUT

Characterization of the Mechanism and Magnitude of Cytoglobin-mediated Nitrite Reduction and Nitric Oxide Generation under Anaerobic Conditions

(2012) Haitao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary nitrate increases tetanic [Ca2+]iand contractile force in mouse fast-twitch muscle

(2012) Andrés Hernández et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats

(2012) Scott K. Ferguson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension

(2012) Edward A. Pankey et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers

(2012) M. Bahra et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A comparison of organic and inorganic nitrates/nitrites

(2012) Sami A. Omar et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

(2011) Amy L. Sindler et al.   AGING CELL

Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans

(2011) Filip J. Larsen et al.   Cell Metabolism

Inhaled Nitrite Reverses Hemolysis-Induced Pulmonary Vasoconstriction in Newborn Lambs Without Blood Participation

(2011) Arlin B. Blood et al.   CIRCULATION

Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

(2011) Charalambos Antoniades et al.   CIRCULATION

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension

(2011) Marcelo F. Montenegro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury

(2011) Cecilia Jädert et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease

(2011) Aarti A. Kenjale et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human Neuroglobin Functions as a Redox-regulated Nitrite Reductase

(2011) Mauro Tiso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P66. Inorganic nitrite attenuates angiotensin ii induced contraction of renal microcirculation via xanthine oxidase-dependent no production

(2011) Mattias Carlstrom et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitrate-Nitrite-Nitric Oxide Pathway

(2010) Eddie Weitzberg et al.   ANESTHESIOLOGY

New perspectives for the treatment of pulmonary hypertension

(2010) Reshma S Baliga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension

(2010) Mattias Carlström et al.   CARDIOVASCULAR RESEARCH

Novel Function of Sulfite Oxidase as a Nitrite Reductase that Generates Nitric Oxide

(2010) Jun Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans

(2010) Vikas Kapil et al.   HYPERTENSION

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice

(2010) Mattias Carlström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction

(2009) Karen Y. Stokes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2

(2009) Christine Y. Ivashchenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

(2009) Claudio Napoli et al.   ARCHIVES OF PHARMACAL RESEARCH

Nitrite exerts potent negative inotropy in the isolated heart via eNOS-independent nitric oxide generation and cGMP–PKG pathway activation

(2009) Daniela Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I

(2009) Cameron Dezfulian et al.   CIRCULATION

Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation

(2009) Brian S. Zuckerbraun et al.   CIRCULATION

Endothelial Dysfunction

(2009) Paul M. Vanhoutte   CIRCULATION JOURNAL

Whole Body UVA Irradiation Lowers Systemic Blood Pressure by Release of Nitric Oxide From Intracutaneous Photolabile Nitric Oxide Derivates

(2009) Christian Opländer et al.   CIRCULATION RESEARCH

Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash

(2009) Joel Petersson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise

(2009) Filip J. Larsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitrite as regulator of hypoxic signaling in mammalian physiology

(2009) Ernst E. van Faassen et al.   MEDICINAL RESEARCH REVIEWS

Clinical translation of nitrite therapy for cardiovascular diseases

(2009) John W. Calvert et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers

(2009) Tanja Sobko et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Bioavailability of sodium nitrite from an aqueous solution in healthy adults

(2009) Claudine C. Hunault et al.   TOXICOLOGY LETTERS

Therapeutic Uses of Inorganic Nitrite and Nitrate

(2008) Anthony R. Butler et al.   CIRCULATION

Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans

(2008) Abdul R. Maher et al.   CIRCULATION

Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

(2008) Andrew J. Webb et al.   HYPERTENSION

Nitric Oxide Production from Nitrite Occurs Primarily in Tissues Not in the Blood

(2008) Haitao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue Processing of Nitrite in Hypoxia

(2008) Martin Feelisch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzyme-Independent NO Stores in Human Skin: Quantification and Influence of UV Radiation

(2008) Megan Mowbray et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis

(2008) Emmelie Å Jansson et al.   Nature Chemical Biology

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

(2008) Jon O. Lundberg et al.   NATURE REVIEWS DRUG DISCOVERY

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis

(2008) D. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myocardial Protection by Nitrite: Evidence That This Reperfusion Therapeutic Will Not Be Lost in Translation

(2008) Shashank S. Sinha et al.   TRENDS IN CARDIOVASCULAR MEDICINE