Clinical implications of omics and systems medicine: focus on predictive and individualized treatment

Systems biology of asthma and allergic diseases: A multiscale approach

(2015) Supinda Bunyavanich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Obama catapults patient-empowered Precision Medicine

(2015) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Refractory asthma: mechanisms, targets, and therapy

(2014) J. L. Trevor et al.   ALLERGY

Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

(2014) Emad Fadhal et al.   BMC Systems Biology

Novel biomarkers for asthma stratification and personalized therapy

(2014) Grzegorz Bartminski et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Gene expression profiling and expanded immunohistochemistry tests to guide the use of adjuvant chemotherapy in breast cancer management: a systematic review and cost-effectiveness analysis

(2014) S Ward et al.   HEALTH TECHNOLOGY ASSESSMENT

New drug costs soar to $2.6 billion

(2014)   NATURE BIOTECHNOLOGY

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy

(2014) S. Bruhn et al.   Science Translational Medicine

Demystifying Disease, Democratizing Health Care

(2014) L. Hood et al.   Science Translational Medicine

Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders

(2014) S. E. Soden et al.   Science Translational Medicine

Enabling multiscale modeling in systems medicine

(2014) Olaf Wolkenhauer et al.   Genome Medicine

Modules, networks and systems medicine for understanding disease and aiding diagnosis

(2014) Mika Gustafsson et al.   Genome Medicine

DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4+ T-Cell Population Structure

(2014) Colm E. Nestor et al.   PLoS Genetics

Targeted omics and systems medicine: personalising care

(2014) Huan Zhang et al.   Lancet Respiratory Medicine

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Application of ’omics technologies to biomarker discovery in inflammatory lung diseases

(2013) Craig E. Wheelock et al.   EUROPEAN RESPIRATORY JOURNAL

Systems medicine: opportunities and challenges for systems biology approaches

(2013) Walter Kolch et al.   FEBS Journal

Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1

(2013) Huan Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systematic identification of proteins that elicit drug side effects

(2013) M. Kuhn et al.   Molecular Systems Biology

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Criteria for the use of omics-based predictors in clinical trials

(2013) Lisa M. McShane et al.   NATURE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

A Randomized Trial of Genotype-Guided Dosing of Warfarin

(2013) Munir Pirmohamed et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases

(2013) S. Chavali et al.   RNA

High-Throughput Methods for Combinatorial Drug Discovery

(2013) X. Sun et al.   Science Translational Medicine

Genomic Medicine: A Decade of Successes, Challenges, and Opportunities

(2013) J. J. McCarthy et al.   Science Translational Medicine

What happened to personalized medicine?

(2012)   NATURE BIOTECHNOLOGY

A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory

(2012) Leroy Hood et al.   New Biotechnology

microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-β Signaling in Glioblastoma

(2012) Giannicola Genovese et al.   Cancer Discovery

Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms

(2012) Fredrik Barrenäs et al.   GENOME BIOLOGY

Translational and systems medicine

(2011) J. Nielsen   JOURNAL OF INTERNAL MEDICINE

Network modeling of the transcriptional effects of copy number aberrations in glioblastoma

(2011) R. Jornsten et al.   Molecular Systems Biology

Identification of Novel Biomarkers in Seasonal Allergic Rhinitis by Combining Proteomic, Multivariate and Pathway Analysis

(2011) Hui Wang et al.   PLoS One

An Integrative Systems Biology Approach to Understanding Pulmonary Diseases

(2010) Charles Auffray et al.   CHEST

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

Systems biology and its application to the understanding of neurological diseases

(2009) Pablo Villoslada et al.   ANNALS OF NEUROLOGY

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology

Dynamic modularity in protein interaction networks predicts breast cancer outcome

(2009) Ian W Taylor et al.   NATURE BIOTECHNOLOGY

Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) Study

(2009) Sara Hägg et al.   PLoS Genetics

Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome

(2008) Angela P Presson et al.   BMC Systems Biology

Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases

(2008) Monika Ray et al.   GENOME BIOLOGY