Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention
Authors
Keywords
-
Journal
JOURNAL OF INTERNAL MEDICINE
Volume 278, Issue 5, Pages 433-446
Publisher
Wiley
Online
2015-10-19
DOI
10.1111/joim.12407
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis
- (2015) K. M. Patel et al. CIRCULATION RESEARCH
- Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus
- (2015) Joost Besseling et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
- (2015) Brian A. Ference et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
- (2015) Daniel I Swerdlow et al. LANCET
- Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
- (2015) Jessica L Mega et al. LANCET
- Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
- (2015) Christopher P. Cannon et al. NEW ENGLAND JOURNAL OF MEDICINE
- A genetic basis for coronary artery disease
- (2015) Robert Roberts TRENDS IN CARDIOVASCULAR MEDICINE
- APOC3, Coronary Disease, and Complexities of Mendelian Randomization
- (2014) Jonathan C. Cohen et al. Cell Metabolism
- Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA2)-V Isoenzyme in Coronary Heart Disease: Modified Mendelian Randomization Analysis Using PLA2G5 Expression Levels
- (2014) M. V. Holmes et al. Circulation-Cardiovascular Genetics
- Design and Rationale of the GAUSS-2 Study Trial: A Double-Blind, Ezetimibe-Controlled Phase 3 Study of the Efficacy and Tolerability of Evolocumab (AMG 145) in Subjects With Hypercholesterolemia Who Are Intolerant of Statin Therapy
- (2014) Leslie Cho et al. CLINICAL CARDIOLOGY
- Statins and the Risk of Diabetes: Evidence From a Large Population-Based Cohort Study
- (2014) Giovanni Corrao et al. DIABETES CARE
- Mendelian randomization of blood lipids for coronary heart disease
- (2014) Michael V. Holmes et al. EUROPEAN HEART JOURNAL
- Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C
- (2014) Nicola H. Dryden et al. GENOME RESEARCH
- Mendelian randomization: genetic anchors for causal inference in epidemiological studies
- (2014) G. Davey Smith et al. HUMAN MOLECULAR GENETICS
- Anti-PCSK9 Antibody Effectively Lowers Cholesterol in Patients With Statin Intolerance
- (2014) Erik Stroes et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
- (2014) Ron Do et al. NATURE
- Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
- (2014) Anders Berg Jørgensen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting APOC3 in the Familial Chylomicronemia Syndrome
- (2014) Daniel Gaudet et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions
- (2014) Stephen Burgess et al. PLoS One
- Apolipoprotein C-III
- (2013) Murray W. Huff et al. CIRCULATION RESEARCH
- Use of allele scores as instrumental variables for Mendelian randomization
- (2013) Stephen Burgess et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
- (2013) Takashi Nagano et al. NATURE
- Common variants associated with plasma triglycerides and risk for coronary artery disease
- (2013) Ron Do et al. NATURE GENETICS
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- Finding genes and variants for lipid levels after genome-wide association analysis
- (2012) Cristen J. Willer et al. CURRENT OPINION IN LIPIDOLOGY
- Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production
- (2012) Zemin Yao et al. CURRENT OPINION IN LIPIDOLOGY
- Inhibition of pre-protein convertase serine kexin-9 (PCSK-9) as a treatment for hyperlipidaemia
- (2012) Anthony S Wierzbicki et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Understanding coronary artery disease using twin studies: Table 1
- (2012) Massimo Mangino et al. HEART
- Functional evaluation of genetic variation in complex human traits
- (2012) D. T. Peters et al. HUMAN MOLECULAR GENETICS
- Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol Levels in Statin-Intolerant Patients
- (2012) David Sullivan et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
- (2012) Alanna Strong et al. JOURNAL OF CLINICAL INVESTIGATION
- Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease
- (2012) Anette Varbo et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial
- (2012) Paul M Ridker et al. LANCET
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- Large-scale association analysis identifies new risk loci for coronary artery disease
- (2012) Panos Deloukas et al. NATURE GENETICS
- Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol
- (2012) Evan A. Stein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy
- (2011) David Preiss JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
- (2011) Olivier Harismendy et al. NATURE
- Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
- (2011) Heribert Schunkert et al. NATURE GENETICS
- A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
- (2011) John F Peden et al. NATURE GENETICS
- Familial Hypercholesterolemia: Present and Future Management
- (2011) B. Sjouke et al. Current Cardiology Reports
- ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21
- (2010) Lesca M. Holdt et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export
- (2010) Mads Kjolby et al. Cell Metabolism
- PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A 2 Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry
- (2010) Juan P. Casas et al. CIRCULATION
- A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo
- (2010) Yan G. Ni et al. JOURNAL OF LIPID RESEARCH
- Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
- (2010) LANCET
- Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
- (2010) Naveed Sattar et al. LANCET
- From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
- (2010) Kiran Musunuru et al. NATURE
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus
- (2009) Olga Jarinova et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis
- (2009) S. N. Rajpathak et al. DIABETES CARE
- The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes
- (2009) Jibin Zeng et al. EXPERIMENTAL CELL RESEARCH
- Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
- (2009) Pia R. Kamstrup JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease
- (2009) Paul Elliott JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
- (2009) Mitchell Guttman et al. NATURE
- Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
- (2009) Sekar Kathiresan et al. NATURE GENETICS
- Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
- (2009) Robert Clarke et al. NEW ENGLAND JOURNAL OF MEDICINE
- Association of Loss-of-Function Mutations in the ABCA1 Gene With High-Density Lipoprotein Cholesterol Levels and Risk of Ischemic Heart Disease
- (2008) Ruth Frikke-Schmidt JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study
- (2008) Aaron R. Folsom et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- (2008) Sekar Kathiresan et al. NATURE GENETICS
- A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection
- (2008) T. I. Pollin et al. SCIENCE
- Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
- (2007) Debbie A. Lawlor et al. STATISTICS IN MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started