Genetic Basis of Atherosclerosis: Insights From Mice and Humans

Histamine Deficiency Decreases Atherosclerosis and Inflammatory Response in Apolipoprotein E Knockout Mice Independently of Serum Cholesterol Level

(2011) Ke-Yong Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apoptosis Signal–Regulating Kinase 1 Deficiency Accelerates Hyperlipidemia-Induced Atheromatous Plaques via Suppression of Macrophage Apoptosis

(2011) Sohsuke Yamada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels

(2011) Nehal N. Mehta et al.   EUROPEAN HEART JOURNAL

Genetic analysis in the Collaborative Cross breeding population

(2011) Vivek M. Philip et al.   GENOME RESEARCH

Collaborative Cross mice and their power to map host susceptibility toAspergillus fumigatusinfection

(2011) Caroline Durrant et al.   GENOME RESEARCH

Loss of Clusterin Limits Atherosclerosis in Apolipoprotein E-deficient Mice via Reduced Expression of Egr-1 and TNF-α

(2011) Narisato Hamada et al.   Journal of Atherosclerosis and Thrombosis

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

(2011) Muredach P Reilly et al.   LANCET

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

(2011) Olivier Harismendy et al.   NATURE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

(2011) Fan Wang et al.   NATURE GENETICS

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

(2011) John F Peden et al.   NATURE GENETICS

Unexpected protective role for Toll-like receptor 3 in the arterial wall

(2011) J. E. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21

(2010) Lesca M. Holdt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aortic Arch Curvature and Atherosclerosis Have Overlapping Quantitative Trait Loci in a Cross Between 129S6/SvEvTac and C57BL/6J Apolipoprotein E–Null Mice

(2010) Hirofumi Tomita et al.   CIRCULATION RESEARCH

Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse

(2010) Merlin C. Thomas et al.   CIRCULATION RESEARCH

11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency Accelerates Atherogenesis and Causes Proinflammatory Changes in the Endothelium inApoe−/−Mice

(2010) Graeme A. Deuchar et al.   ENDOCRINOLOGY

ADAMTS proteases: key roles in atherosclerosis?

(2010) Rebecca C. Salter et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

(2010) Axel Visel et al.   NATURE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

(2010) Solveig Gretarsdottir et al.   NATURE GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus

(2009) Olga Jarinova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10

(2009) John A. Kelly et al.   CARDIOVASCULAR RESEARCH

Ablation of Neutral Cholesterol Ester Hydrolase 1 Accelerates Atherosclerosis

(2009) Motohiro Sekiya et al.   Cell Metabolism

Endothelial-Specific Deletion of Connexin40 Promotes Atherosclerosis by Increasing CD73-Dependent Leukocyte Adhesion

(2009) C.E. Chadjichristos et al.   CIRCULATION

ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries

(2009) Li Wang et al.   CIRCULATION RESEARCH

Four additional mouse crosses improve the lipid QTL landscape and identifyLipgas a QTL gene

(2009) Zhiguang Su et al.   JOURNAL OF LIPID RESEARCH

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

New susceptibility locus for coronary artery disease on chromosome 3q22.3

(2009) Jeanette Erdmann et al.   NATURE GENETICS

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

(2009) Sekar Kathiresan et al.   NATURE GENETICS

Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding

(2009) Janet Chamberlain et al.   PLoS One

Prostaglandin F2  elevates blood pressure and promotes atherosclerosis

(2009) Y. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice

(2008) Reema Goel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased ADAM17 mRNA Expression and Activity Is Associated With Atherosclerosis Resistance in LDL-Receptor Deficient Mice

(2008) Lesca M. Holdt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association Between ADAMTS1 Matrix Metalloproteinase Gene Variation, Coronary Heart Disease, and Benefit of Statin Therapy

(2008) Marc S. Sabatine et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Farp2 and Stk25 Are Candidate Genes for the HDL Cholesterol Locus on Mouse Chromosome 1

(2008) Zhiguang Su et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

(2008) Hironori Adachi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of PDZK1 on lipoprotein metabolism and atherosclerosis

(2008) Olivier Kocher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Discoidin Domain Receptor 1 ( Ddr1 ) Deletion Decreases Atherosclerosis by Accelerating Matrix Accumulation and Reducing Inflammation in Low-Density Lipoprotein Receptor–Deficient Mice

(2008) Christopher Franco et al.   CIRCULATION RESEARCH

Arterial remodeling in vascular disease: a key role for hyaluronan and versican

(2008) Thomas et al.   Frontiers in Bioscience-Landmark

Applying Gene Expression, Proteomics and Single-Nucleotide Polymorphism Analysis for Complex Trait Gene Identification

(2008) I. M. Stylianou et al.   GENETICS

Differences in DBA/1J and DBA/2J reveal lipid QTL genes

(2008) Ioannis M. Stylianou et al.   JOURNAL OF LIPID RESEARCH

Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population

(2008) Werner Koch et al.   NATURE GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

(2008) Brendan J. Keating et al.   PLoS One

Galectin-3 Gene Inactivation Reduces Atherosclerotic Lesions and Adventitial Inflammation in ApoE-Deficient Mice

(2007) Maurice Nachtigal et al.   AMERICAN JOURNAL OF PATHOLOGY

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques

(2007) Dick Wågsäter et al.   ATHEROSCLEROSIS

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 −/− Mice

(2007) Noah Saederup et al.   CIRCULATION

Quantitative Trait Locus Analysis of Carotid Atherosclerosis in an Intercross Between C57BL/6 and C3H Apolipoprotein E–Deficient Mice

(2007) Qiongzhen Li et al.   STROKE