Molecular Imaging of Atherosclerosis for Improving Diagnostic and Therapeutic Development

Molecular Imaging of Cathepsin B Proteolytic Enzyme Activity Reflects the Inflammatory Component of Atherosclerotic Pathology and Can Quantitatively Demonstrate the Antiatherosclerotic Therapeutic Effects of Atorvastatin and Glucosamine

(2018) Dong-Eog Kim et al.   Molecular Imaging

Real-Time Video Imaging of Protease Expression In Vivo

(2012) Lei Zhu et al.   Theranostics

Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy

(2011) Carlos Tassa et al.   ACCOUNTS OF CHEMICAL RESEARCH

Contrast-Enhanced Ultrasound for Assessing Carotid Atherosclerotic Plaque Lesions

(2011) Sasan Partovi et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Selective Inhibition of Matrix Metalloproteinase-13 Increases Collagen Content of Established Mouse Atherosclerosis

(2011) Thibaut Quillard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: Rational design through target quantification

(2011) Andrew Jefferson et al.   ATHEROSCLEROSIS

The potential role of preventing atherosclerosis by induction of neonatal tolerance to VLDL

(2011) Kai Cui et al.   CELLULAR IMMUNOLOGY

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

(2011) Christopher J. O'Donnell et al.   CIRCULATION

m-Calpain Induction in Vascular Endothelial Cells on Human and Mouse Atheromas and Its Roles in VE-Cadherin Disorganization and Atherosclerosis

(2011) Takuro Miyazaki et al.   CIRCULATION

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Assessment of Valvular Calcification and Inflammation by Positron Emission Tomography in Patients With Aortic Stenosis

(2011) Marc Richard Dweck et al.   CIRCULATION

Molecular Imaging of Coronary Atherosclerosis and Myocardial Infarction

(2011) Florian Leuschner et al.   CIRCULATION RESEARCH

Molecular Magnetic Resonance Imaging Allows the Detection of Activated Platelets in a New Mouse Model of Coronary Artery Thrombosis

(2011) Daniel Duerschmied et al.   INVESTIGATIVE RADIOLOGY

Increased T Cell Proliferative Responses to Islet Antigens Identify Clinical Responders to Anti-CD20 Monoclonal Antibody (Rituximab) Therapy in Type 1 Diabetes

(2011) K. C. Herold et al.   JOURNAL OF IMMUNOLOGY

Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation

(2011) F. Rouzet et al.   JOURNAL OF NUCLEAR MEDICINE

What Can Be Seen by 18F-FDG PET in Atherosclerosis Imaging? The Effect of Foam Cell Formation on 18F-FDG Uptake to Macrophages In Vitro

(2011) M. Ogawa et al.   JOURNAL OF NUCLEAR MEDICINE

Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation

(2011) M. Razavian et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo Characterization of a New Abdominal Aortic Aneurysm Mouse Model With Conventional and Molecular Magnetic Resonance Imaging

(2011) Ahmed Klink et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypoxia But Not Inflammation Augments Glucose Uptake in Human Macrophages

(2011) Eduardo J. Folco et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial

(2011) Zahi A Fayad et al.   LANCET

Multispectral Optoacoustic Tomography of Matrix Metalloproteinase Activity in Vulnerable Human Carotid Plaques

(2011) Daniel Razansky et al.   MOLECULAR IMAGING AND BIOLOGY

HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms

(2011) Mohamad Navab et al.   Nature Reviews Cardiology

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Different Capacity of Monocyte Subsets to Phagocytose Iron-Oxide Nanoparticles

(2011) Marcus Settles et al.   PLoS One

Coronary Imaging With Cardiovascular Magnetic Resonance: Current State of the Art

(2011) Amedeo Chiribiri et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques

(2011) C. Vinegoni et al.   Science Translational Medicine

Pioglitazone Suppresses Inflammation In Vivo in Murine Carotid Atherosclerosis

(2010) Kiyuk Chang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris

(2010) Toshio Imanishi et al.   ATHEROSCLEROSIS

Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress

(2010) Tracie A. Seimon et al.   Cell Metabolism

High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis

(2010) Kunio Morishige et al.   CIRCULATION

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Molecular Imaging of Atherosclerotic Plaques Targeted to Oxidized LDL Receptor LOX-1 by SPECT/CT and Magnetic Resonance

(2010) Dayuan Li et al.   Circulation-Cardiovascular Imaging

Circulating CD14+CD16+ monocyte levels predict tissue invasive character of cholangiocarcinoma

(2010) C. Subimerb et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inclusion body myositis in a patient with long standing rheumatoid arthritis treated with anti-TNFα and rituximab

(2010) Stefan Vordenbäumen et al.   CLINICAL RHEUMATOLOGY

Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity

(2010) Lorenzo Tei et al.   Contrast Media & Molecular Imaging

Does Statin Therapy Affect the Progression of Atherosclerosis Measured by a Coronary Calcium Score?

(2010) Edward A. Gill   Current Atherosclerosis Reports

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation

(2010) Jesper Hjortnaes et al.   EUROPEAN HEART JOURNAL

Albumin-based Microbubbles Bind Up-regulated Scavenger Receptors following Vascular Injury

(2010) Daniel R. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo high-resolution structural imaging of large arteries in small rodents using two-photon laser scanning microscopy

(2010) Remco T. A. Megens et al.   JOURNAL OF BIOMEDICAL OPTICS

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

(2010) E. S. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bimodal Thrombus Imaging: Simultaneous PET/MR Imaging with a Fibrin-targeted Dual PET/MR Probe—Feasibility Study in Rat Model

(2010) Ritika Uppal et al.   RADIOLOGY

Feasibility of FDG Imaging of the Coronary Arteries

(2010) Ian S. Rogers et al.   JACC-Cardiovascular Imaging

Molecular Imaging of the Initial Inflammatory Response in Atherosclerosis

(2009) Beat A. Kaufmann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An approach to molecular imaging of atherosclerosis, thrombosis, and vascular inflammation using microparticles of iron oxide

(2009) Martina A. McAteer et al.   ATHEROSCLEROSIS

Multimodal Nanoagents for the Detection of Intravascular Thrombi

(2009) Jason R. McCarthy et al.   BIOCONJUGATE CHEMISTRY

Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice

(2009) Kim L.L. Habets et al.   CARDIOVASCULAR RESEARCH

Multispectral Near-Infrared Fluorescence Molecular Imaging of Matrix Metalloproteinases in a Human Carotid Plaque Using a Matrix-Degrading Metalloproteinase–Sensitive Activatable Fluorescent Probe

(2009) Bastiaan M. Wallis de Vries et al.   CIRCULATION

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Molecular MRI of Cardiomyocyte Apoptosis With Simultaneous Delayed-Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo

(2009) David E. Sosnovik et al.   Circulation-Cardiovascular Imaging

Evaluation of α v β 3 Integrin-Targeted Positron Emission Tomography Tracer 18 F-Galacto-RGD for Imaging of Vascular Inflammation in Atherosclerotic Mice

(2009) Iina Laitinen et al.   Circulation-Cardiovascular Imaging

Integrins and proximal signaling mechanisms in cardiovascular disease

(2009) Hind Lal   Frontiers in Bioscience-Landmark

Thrombus Imaging With Fibrin-Specific Gadolinium-Based MR Contrast Agent EP-2104R

(2009) Josef Vymazal et al.   INVESTIGATIVE RADIOLOGY

Effect of Fluvastatin on Progression of Coronary Atherosclerotic Plaque Evaluated by Virtual Histology Intravascular Ultrasound

(2009) Kenya Nasu et al.   JACC-Cardiovascular Interventions

Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow

(2009) E.A. Ferrante et al.   JOURNAL OF CONTROLLED RELEASE

Diffusion-Weighted Magnetic Resonance Imaging Reversal by Gene Knockdown of Matrix Metalloproteinase-9 Activities in Live Animal Brains

(2009) C. H. Liu et al.   JOURNAL OF NEUROSCIENCE

Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis

(2009) Nezam Haider et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation

(2009) Peter Panizzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Collagen Targeting Using Protein-Functionalized Micelles: The Strength of Multiple Weak Interactions

(2009) Sanne W. A. Reulen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study

(2009) Tjun Y. Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High-Affinity αvβ3 Integrin Targeted Optical Probe as a New Imaging Biomarker for Early Atherosclerosis: Initial Studies in Watanabe Rabbits

(2009) Julie Heroux et al.   MOLECULAR IMAGING AND BIOLOGY

Renal vascular inflammation induced by Western diet in ApoE-null mice quantified by 19F NMR of VCAM-1 targeted nanobeacons

(2009) Richard Southworth et al.   Nanomedicine-Nanotechnology Biology and Medicine

Calcification in atherosclerosis

(2009) Nikolaos Alexopoulos et al.   Nature Reviews Cardiology

Atherosclerosis and Matrix Metalloproteinases: Experimental Molecular MR Imaging in Vivo

(2009) Vardan Amirbekian et al.   RADIOLOGY

18F-4V for PET–CT Imaging of VCAM-1 Expression in Atherosclerosis

(2009) Matthias Nahrendorf et al.   JACC-Cardiovascular Imaging

Molecular MRI of Early Thrombus Formation Using a Bimodal α2-Antiplasmin–Based Contrast Agent

(2009) Robbert-Jan J.H.M. Miserus et al.   JACC-Cardiovascular Imaging

Coronary Artery Calcification Compared With Carotid Intima-Media Thickness in the Prediction of Cardiovascular Disease IncidenceThe Multi-Ethnic Study of Atherosclerosis (MESA)

(2008) Aaron R. Folsom   ARCHIVES OF INTERNAL MEDICINE

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

(2008) Andrew C. Newby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Development of an optimized activatable MMP-14 targeted SPECT imaging probe

(2008) Gregory A. Watkins et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular imaging of αvβ3 integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA†

(2008) Carmen Burtea et al.   CARDIOVASCULAR RESEARCH

Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis

(2008) C. von zur Muhlen et al.   CIRCULATION

Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis

(2008) Farouc A. Jaffer et al.   CIRCULATION

Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury

(2008) Matthias Nahrendorf et al.   CIRCULATION

Reversal of Vascular 18F-FDG Uptake with Plasma High-Density Lipoprotein Elevation by Atherogenic Risk Reduction

(2008) S. J. Lee et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting of Lectinlike Oxidized Low-Density Lipoprotein Receptor 1 (LOX-1) with 99mTc-Labeled Anti-LOX-1 Antibody: Potential Agent for Imaging of Vulnerable Plaque

(2008) S. Ishino et al.   JOURNAL OF NUCLEAR MEDICINE

Noninvasive Detection of Macrophage-Rich Atherosclerotic Plaque in Hyperlipidemic Rabbits Using “Positive Contrast” Magnetic Resonance Imaging

(2008) Grigorios Korosoglou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Visualization of Activated Platelets by Targeted Magnetic Resonance Imaging Utilizing Conformation-Specific Antibodies against Glycoprotein IIb/IIIa

(2008) Constantin von zur Muhlen et al.   JOURNAL OF VASCULAR RESEARCH

Novel and Engineered Anti–B-Cell Monoclonal Antibodies for Non-Hodgkin’s Lymphoma

(2008) Peter Martin et al.   SEMINARS IN HEMATOLOGY

Antiangiogenic Synergism of Integrin-Targeted Fumagillin Nanoparticles and Atorvastatin in Atherosclerosis

(2008) Patrick M. Winter et al.   JACC-Cardiovascular Imaging

Magnetic Resonance Imaging of Endothelial Adhesion Molecules in Mouse Atherosclerosis Using Dual-Targeted Microparticles of Iron Oxide

(2007) Martina A. McAteer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis

(2007) Matthias Nahrendorf et al.   CIRCULATION