Article
Peripheral Vascular Disease
Raul R. Rodrigues-Diez, Antonio Tejera-Munoz, Vanesa Esteban, Lasse B. Steffensen, Raquel Rodrigues-Diez, Macarena Orejudo, Sandra Rayego-Mateos, Lucas L. Falke, Pablo Cannata-Ortiz, Alberto Ortiz, Jesus Egido, Ziad Mallat, M. Briones Ana, M. Auxiliadora Bajo, Roel Goldschmeding, Marta Ruiz-Ortega
Summary: This study reveals the critical involvement of CCN2 in the homeostasis and response to vascular injury of the aorta, particularly under Ang II-induced stress. CCN2 deletion leads to rapid development and rupture of aortic aneurysms, with the maintenance of aortic integrity partially dependent on the aldosterone pathway.
Review
Cell Biology
Akiko Mammoto, Kienna Matus, Tadanori Mammoto
Summary: The aging population is rapidly increasing, with arterial aging leading to various age-related pathologies such as cardiovascular diseases. Age-related changes in the aortic wall affect stable circulation and lead to organ dysfunction. Remodeling of the extracellular matrix is a hallmark of aortic functional stiffening in aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aoife Smyth, Breedge Callaghan, Colin E. Willoughby, Colm O'Brien
Summary: Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. miR-29 has been found to have anti-fibrotic effects and may play an important role in the diagnosis and treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chuncheng Liu, Linan Liu, Jinlai Bo, Xian Lu, Donghui Qu, Gehui Liu, Zhiyan Jiang, Lu Cai
Summary: Intratumoral hypoxia affects multiple tumor exacerbations and treatment procedures, and its interaction with the extracellular matrix influences cancer growth. The downregulation of miR-29b was observed in hypoxia-stressed mouse kidney tumor cells. Complementary sites to miR-29 were found in the 3'UTRs of extracellular matrix-related genes, including collagen IV. The study provides a theoretical basis for tumor and fibrosis research and treatment by exploring the regulation of miR-29 and extracellular matrix under hypoxia.
Article
Biotechnology & Applied Microbiology
Yunlong Liu, Junyi Liu, Yan Ma, Yongyong Zhang, Qiong Chen, Xin Yang, Yanchun Shang
Summary: This study reveals that Olmesartan exerts a protective effect on IL-29-induced cartilage degradation by inhibiting the expression of MMPs and ADAMTSs, reducing ECM degradation, and suppressing the activation of the NF-κB pathway, thereby demonstrating its anti-inflammatory properties.
Article
Engineering, Biomedical
Aylin Acun, Ruben Oganesyan, Korkut Uygun, Heidi Yeh, Martin L. Yarmush, Basak E. Uygun
Summary: The extracellular matrix of the liver changes with age, affecting cell function, and donor age should be considered an important factor for bioengineering liver substitutes.
Article
Geriatrics & Gerontology
Juan Luis Sanchez-Sanchez, Isabelle Ader, Yannick Jeanson, Valerie Planat-Benard, Bruno Vellas, Louis Casteilla, Philipe de Souto-Barreto
Summary: Plasma periostin levels were found to be associated with declines in both physical and cognitive capacities in older adults over a 4-year follow-up.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Hematology
Brittany Balint, Sebastien Hergalant, Jean-Michel Camadro, Sebastien Blaise, Laetitia Vanalderwiert, Laurent Lignieres, Rosa-Maria Gueant-Rodriguez, Jean-Louis Gueant
Summary: The study explores the impact of MDD fetal programming on the ascending aorta in aged rats, revealing significant alterations in structure and integrity, especially in elastin breaks which are inversely correlated with blood pressure. These findings contribute to understanding why homocysteine-lowering vitamin B supplementation fails to alleviate vascular complications in adulthood.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Dar Weiss, Aaron S. Long, George Tellides, Stephane Avril, Jay D. Humphrey, Matthew R. Bersi
Summary: This study investigated the natural history of thoracic aortopathy in a mouse model and found that wall composition and material properties are compromised in regions of local mural defects, which further increases the dilatation and structural vulnerability of the wall.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biology
Antonion Korcari, Anne E. C. Nichols, Mark R. Buckley, Alayna E. Loiselle, Mei Wan
Summary: Aged tendons disrupt homeostasis, increase injury risk, and impair healing capacity. Understanding the mechanisms of homeostatic disruption is crucial for developing therapeutics to maintain tendon health.
Letter
Pharmacology & Pharmacy
Dick Wagsater, Amanda Balboa Ramilo, Mikaela Nasstrom, Anne Kunath, Mediha Becirovic Agic, Kevin Mani, Anders Wanhainen, Marcelo Heron Petri
Summary: MicroRNA-10b (miR-10b) is associated with increased mortality rate due to aortic rupture in abdominal aortic aneurysm (AAA) animal models. The study suggests that miR-10b not only serves as a marker for AAA, but also plays a functional role in aneurysm development and rupture. More mechanistic studies are needed to further understand the role of miR-10b in AAA formation.
VASCULAR PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alla Zorina, Vadim Zorin, Dmitry Kudlay, Pavel Kopnin
Summary: Skin aging is a multi-factorial process that involves impairment of skin structures and functions, particularly in the dermal extracellular matrix (ECM), leading to disrupted functioning of dermal fibroblasts (DFs). The integrity of the collagen matrix (CM) is crucial for proper adhesion and mechanical tension in DFs, allowing them to maintain collagen homeostasis. Impaired CM integrity disrupts mechanotransduction and impairs DF functioning, contributing to the progression of aging processes in skin tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Tyler J. Creamer, Emily E. Bramel, Elena Gallo MacFarlane
Summary: Thoracic aortic aneurysms (TAA) are permanent dilations of the aorta that predispose patients to life-threatening aortic dissection or rupture. Pathogenic variants causing hereditary TAA compromise molecular processes essential for aortic homeostasis. These variants impair signal transduction and signaling pathways involved in the modulation of vascular smooth muscle cells (VSMCs) responses to mechanical and biochemical cues from their environment, ultimately leading to vessel degeneration and mechanical failure.
Article
Multidisciplinary Sciences
Shizhi Wang, Qingwen Yuan, Wenpeng Zhao, Weimin Zhou
Summary: This study identified 65 differentially expressed circular RNAs in AAA tissues compared to normal tissues, with circRBM33 being significantly increased in AAA tissues and Ang II-induced VSMCs. The findings suggest that circRBM33 may play a role in AAA progression by regulating ECM degradation via the miR-4268/EPHB2 axis.
Article
Engineering, Biomedical
Mariana Reis, Yvette Alania, Ariene Leme-Kraus, Robert Free, Derk Joester, Weikang Ma, Thomas Irving, Ana K. Bedran-Russo
Summary: Aging has a profound impact on the biology and function of human teeth. The stiffness of root dentin increases with age, but its ability to dissipate energy during deformation does not decay. The damping factor of the organic matrix deteriorates with age. Altered matrix-mineral interactions and changes in glycosaminoglycans may counteract the negative effects of aging on the structural components of the extracellular matrix.
ACTA BIOMATERIALIA
(2022)
Review
Cell Biology
Glynnis A. Garry, Rhonda Bassel-Duby, Eric N. Olson
Summary: Ischemic heart disease is the leading cause of morbidity and mortality worldwide, and finding new ways to promote cardiomyocyte regeneration is crucial. Direct reprogramming of cardiac fibroblasts into induced cardiac-like myocytes (iCMs) has shown promising potential, but there are challenges in reprogramming adult human fibroblasts.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Catherine A. Makarewich, Amir Z. Munir, Svetlana Bezprozvannaya, Aaron M. Gibson, Soo Young Kim, Misty S. Martin-Sandoval, Thomas P. Mathews, Luke I. Szweda, Rhonda Bassel-Duby, Eric N. Olson
Summary: New evidence suggests that certain noncoding RNA molecules actually code for microproteins. By using comparative genomics, researchers identified a microprotein called Mtlbn that is abundantly expressed in the heart. Mtlbn localizes to the inner mitochondrial membrane and interacts with subunits of the electron transport chain and respiratory supercomplexes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Peiheng Gan, Zhaoning Wang, Maria Gabriela Morales, Yu Zhang, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Summary: This study identified a genetic defect associated with noncompaction cardiomyopathy and revealed some underlying mechanisms. The loss of Rbpms gene led to premature cardiomyocyte binucleation and cell cycle arrest, in which Rbpms mediated the isoform switching of a specific protein.
DEVELOPMENTAL CELL
(2022)
Article
Medicine, Research & Experimental
Dileep R. Karri, Yu Zhang, Francesco Chemello, Yi-Li Min, Jian Huang, Jiwoong Kim, Pradeep P. A. Mammen, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson
Summary: This study demonstrates the long-term durability of CRISPR/Cas9 genome editing as a therapy for maintaining the integrity and function of DMD muscle, even under conditions of stress.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Cardiac & Cardiovascular Systems
Ning Liu, Eric N. Olson
Summary: Cardiovascular disease is the leading cause of deaths and illnesses in developed countries. Mouse models have played a significant role in studying the complex signaling pathways, genetic and epigenetic regulations, and multicellular interactions involved in cardiovascular disease. The advent of CRISPR genome editing has revolutionized cardiovascular research, allowing for rapid modeling and potential genetic correction of disease-causing mutations.
CIRCULATION RESEARCH
(2022)
Article
Geriatrics & Gerontology
Mina Shahriyari, Md Rezaul Islam, Sadman M. Sakib, Malte Rinn, Anastasia Rika, Dennis Krueger, Lalit Kaurani, Verena Gisa, Mandy Winterhoff, Harithaa Anandakumar, Orr Shomroni, Matthias Schmidt, Gabriela Salinas, Andreas Unger, Wolfgang A. Linke, Jana Zschuentzsch, Jens Schmidt, Rhonda Bassel-Duby, Eric N. Olson, Andre Fischer, Wolfram-Hubertus Zimmermann, Malte Tiburcy
Summary: This study successfully established methods for deriving skeletal muscle cells from human pluripotent stem cells and engineered a functional human skeletal muscle organoid and engineered skeletal muscle with regeneration-competent satellite-like cells. Contractile performance of the engineered muscle was further enhanced by thyroid hormone treatment.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Immunology
Ildiko Bock-Marquette, Klaudia Maar, Szabolcs Maar, Balint Lippai, Gabor Faskerti, Ferenc Gallyas, Eric N. Olson, Deepak Srivastava
Summary: Our dream of defeating the processes of organ damage and aging remains a challenge, and steps towards regenerating individual organs are considered significant. Through interconnecting our collective knowledge regarding aging and embryonic development, we propose to discover molecules that can effectively reverse cellular damage. Our results regarding Thymosin beta-4 (TB4) support this hypothesis, showing its potential to promote cardiac cell migration and survival, enhance myocyte survival and improve cardiac function, and activate epicardial progenitor cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Xurde M. Caravia, Andres Ramirez-Martinez, Peiheng Gan, John R. McAnally, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Zegeye Hailu Jebessa, Andrea Schneider, Matthias Dewenter, Michael Berlin, Catherine A. Makarewich, Eric N. Olson, Marc Freichel, Martin Busch, Johannes Backs, Patrick Most
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Takahiko Nishiyama, Yu Zhang, John Mcanally, Lin Xu, Ning Liu, Rhonda S. Bassel-Duby, Eric N. Olson
Meeting Abstract
Cardiac & Cardiovascular Systems
N. M. Stege, T. R. Eijgenraam, V. Oliveira Nunes Teixeira, A. M. Feringa, E. M. Schouten, C. A. Makarewich, R. Bassel-Duby, E. N. Olson, R. A. De Boer, H. H. W. Sillje
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
I. Bock-Marquette, K. Maar, S. Maar, B. Lippai, G. Faskerti, D. Hanna, J. Thatcher, E. N. Olson, F. Gallyas
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Meeting Abstract
Transplantation
Tobias Bohnenpoll, Eric Olson, Mykola Dergai, Jennifer Cox, Simone Romoli, I-Ju Lo, Johannes Pospiech, Krishan Vishnolia, Mark Mcconnell, Marvin Gunawan, Michaela Bayerlova, Nicolette Honson, Niklas Michel, Nikolas Stroth, Olivier Radresa, Philipp Skroblin, Priyanka Kohli, Seamus Ragan, Shenshen Lai, Steven Bromidge, David Powell, Uwe Andag, Andrew King
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Eric Olson, Mark Mcconnell, Seamus Ragan, Jennifer Cox, Jeff Lester, Charles Nieh, Jay Kuo, Andrew King
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Andres Ramirez-Martinez, Yichi Zhang, Marie-Jose Van den Boogaard, John R. McAnally, Cristina Rodriguez-Caycedo, Andreas C. Chai, Francesco Chemello, Maarten P. G. Massink, Inge Cuppen, Martin G. Elferink, Robert J. J. van Es, Nard G. Janssen, Linda P. A. M. Walraven-van Oijen, Ning Liu, Rhonda Bassel-Duby, Richard H. van Jaarsveld, Eric N. Olson
Summary: The study identifies a variant of the MYMX gene that is associated with CFZS-like abnormalities, leading to impaired fusion activity. Patient-derived cells and mouse models confirm the pathogenic role of this variant and CRISPR/Cas9 gene editing shows potential for therapeutic intervention.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
