Article
Chemistry, Multidisciplinary
Di Zhang, Ming-ming Zhao, Ji-min Wu, Rui Wang, Gang Xue, Yan-bo Xue, Ji-qi Shao, You-yi Zhang, Er-dan Dong, Zhi-yuan Li, Han Xiao
Summary: It has been found that sympathetic overactivation under strong acute stresses is common in cardiovascular diseases, leading to acute cardiovascular events. Alpha(1)-ARs and beta-ARs, two subtypes of adrenergic receptors in the heart, play a significant role in the regulation of these processes. This study compared the temporal gene expression profiles of acute alpha(1)-AR and beta-AR activation in the heart, finding that alpha(1)-AR activation leads to sustained inflammatory gene expression and neutrophil infiltration, while beta-AR activation induces transient inflammation. Additionally, alpha(1)-AR overactivation results in more metabolic disorders compared to beta-AR overactivation. These findings suggest that blocking alpha(1)-AR should be considered in the treatment of acute stress-associated cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Plant Sciences
Mubarak Hussaini Ahmad, Abdulkadir Umar Zezi, Sherifat Bola Anafi, Zakariyya Alhassan, Mustapha Mohammed, Rabi'u Nuhu Danraka
Summary: The study aimed to elucidate the potential mechanisms of antidiarrhoeal activity of methanol leaf extract of Combretum hypopilinum. Results suggest the possible involvement of opioidergic and (alpha(1) and beta)-adrenergic systems.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
M. Archer, N. Dogra, Z. Dovey, T. Ganta, H-S Jang, J. A. Khusid, A. Lantz, M. Mihalopoulos, J. A. Stockert, A. Zahalka, L. Bjornebo, S. Gaglani, M. R. Noh, S. A. Kaplan, R. Mehrazin, K. K. Badani, P. Wiklund, K. Tsao, D. J. Lundon, N. Mohamed, F. Lucien, B. Padanilam, M. Gupta, A. K. Tewari, N. Kyprianou
Summary: The autonomic nervous system plays a critical role in regulating the phenotypic landscape of genitourinary organs, particularly in tumor growth. Pharmacologic intervention with adrenoceptor antagonists has been successful in treating certain benign urologic diseases.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Moshe Katz, Suraj Subramaniam, Orna Chomsky-Hecht, Vladimir Tsemakhovich, Veit Flockerzi, Enno Klussmann, Joel A. Hirsch, Sharon Weiss, Nathan Dascal
Summary: CaV1.2 channels play a crucial role in regulating cardiac muscle contraction, with 0-AR increasing contraction by enhancing calcium influx through these channels via PKA activation. A recent study identified Rad as essential for PKA regulation of CaV1.2, revealing two distinct pathways of PKA modulation of CaV1.2: Rad dependent and Rad independent.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Shuo Sun, Feng Zhang, Yan Pan, Yu Xu, Aidong Chen, Jian Wang, Haiyang Tang, Ying Han
Summary: The study found that plasma levels of Salusin-beta and its protein expressions in the arteries of SHR were significantly higher compared to WKY. Salusin-beta increased arterial blood pressure in SHR, while anti-Salusin-beta IgG decreased it. Furthermore, Salusin-beta exacerbated the impaired ACh-induced relaxation and decreased NO release in arteries of SHR, indicating its involvement in the pathogenesis of attenuated endothelium-dependent vasodilatation in hypertension.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Abrahim Mahmood, Kinza Ahmed, Youhua Zhang
Summary: Cardiac sympathetic activation and abnormal Ca2+ handling are important factors in the progression of heart failure. The interaction between beta-adrenergic receptor desensitization/down-regulation and abnormal Ca2+ handling in heart failure leads to cardiac dysfunction and arrhythmias.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Xue-Ping Zhong, Wen-Fang Xia
Summary: Recent studies have shown that the sympathetic nervous system can regulate bone metabolism by activating beta-adrenergic receptors on osteoblasts and osteoclasts. It is important to investigate whether beta-blockers have a beneficial effect on bone metabolism in the treatment of cardiovascular diseases, in order to expand their clinical application. This article reviews the effects of beta-blockers on bone metabolism and the progress of clinical research in this area.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Medicine, Research & Experimental
Yan Pan, Aidong Chen, Xingxing Wang, Changlei Bao, Shuxin Liang, Haiyang Tang, Ying Han
Summary: This study investigated the effects of salusin-beta on endothelium-dependent vascular relaxation and the progression of PAH. The results showed that elevated salusin-beta levels in PAH rats led to reduced endothelium-dependent vasodilatation and participated in PAH progression by stimulating NAD(P)H oxidase-ROS production and inhibiting eNOS-NO release.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Peripheral Vascular Disease
Natalia M. Mathieu, Pablo Nakagawa, Connie C. Grobe, John J. Reho, Daniel T. Brozoski, Ko-Ting Lu, Kelsey K. Wackman, McKenzie L. Ritter, Jeffrey L. Segar, Justin L. Grobe, Curt D. Sigmund
Summary: In salt-sensitive hypertension, ARRB2 may counterbalance the canonical signaling of GPCRs, while ARRB1 has no significant effect.
Article
Physiology
Liam Hovey, Xiaoyun Guo, Yi Chen, Qinghang Liu, William A. Catterall
Summary: This study evaluated the inotropic response of mice with mutations in C-terminal phosphoregulatory sites under physiological levels of beta-adrenergic stimulation and the impact of combining mutations with chronic pressure overload stress. Mice with specific mutations showed impaired baseline regulation of ventricular contractility and decreased response to low doses of beta-adrenergic agonist. However, treatment with supraphysiological doses of agonist revealed compensatory inotropic reserve. These findings highlight the importance of phosphorylation of Ca(V)1.2 at regulatory sites in maintaining normal cardiac homeostasis and adapting to stress.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Jianmin Ling, Shanshan Yu, Feng Xiong, Shusheng Li
Summary: This study found that up-regulated HSPB8 expression in the brain of mice with lipopolysaccharide-induced sepsis improved cognitive decline in SAE mice. Exogenous HSPB8 also exerted neuroprotective effects and salvaged synaptic function through regulating mitochondrial biogenesis and fission in a lipopolysaccharide-induced mouse model. Furthermore, HSPB8 overexpression inhibited IBA1 and NLRP3 activation in the SAE model. These findings suggest that HSPB8 overexpression may be an efficient treatment for relieving SAE-related cognitive decline.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Elaine Shanahan, Sheila Ryan, Aoife Leahy, Tina Sheehy, Aine Costelloe, Amrita Roy, Rose Galvin, Catherine Peters, Declan Lyons, Margaret O'Connor
Summary: This study aimed to investigate the abnormal autonomic nervous system function in delirious patients, and found different blood pressure responses in delirium group during tilt testing. Results showed that as the severity of delirium increased, the systolic blood pressure change during tilting also increased.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Environmental Sciences
Chien-Jen Wang, Huei-Ju Liu, Tzu-Chieh Chou, Ching-Chun Lin, Wen-Harn Pan, Pau-Chung Chen, Jing-Fang Hsu
Summary: An analytical method for simultaneously measuring eight beta-adrenergic agonist compounds in human urine was established. The method demonstrated high precision, accuracy, and capability for investigating the presence of these compounds in human populations, particularly in Taiwan.
Article
Biochemistry & Molecular Biology
Veronica D'Ezio, Marco Colasanti, Tiziana Persichini
Summary: Amyloid-beta deposition in Alzheimer's disease induces oxidative stress and neuronal damage. Aβ(25-35) activates antioxidant response in astrocytes, leading to increased neuronal mortality due to glutamate release. Inhibition of System X-c(-) can reduce neuronal death and glutamate levels, with NMDA receptor activation playing a role in the pathway.
Article
Biochemistry & Molecular Biology
Ravel Ray, Hind Al Khashali, Ben Haddad, Jadziah Wareham, Kai-Ling Coleman, Danyah Alomari, Robert Ranzenberger, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Summary: Nicotine and BDNF treatment decrease the sensitivity of NSCLC cell lines to cisplatin, while treatment with propranolol has the opposite effect. Activation of EGFR and IGF-1R by epinephrine or nicotine reduces cell sensitivity to cisplatin, whereas inhibiting their activation increases sensitivity. Nicotine and BDNF upregulate PI3K and AKT activities, while inhibiting them increases apoptosis and cisplatin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Carlos Galan-Arriola, Jean Paul Vilchez-Tschischke, Manuel Lobo, Gonzalo J. Lopez, Antonio De Molina-Iracheta, Claudia Perez-Martinez, Rocio Villena-Gutierrez, Alvaro Macias, Ivan A. Diaz-Rengifo, Eduardo Oliver, Valentin Fuster, Javier Sanchez-Gonzalez, Borja Ibanez
Summary: The aim of this study was to investigate the changes in coronary microcirculation status during and after repeated anthracycline treatment. The results showed that anthracycline treatment is associated with progressive and irreversible damage to the microcirculation. The damage to the microcirculation persists even in low cumulative dose regimes and may explain the increased incidence of cardiovascular events in cancer survivors who received anthracyclines without cardiac contractile defects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biology
J. J. Serrano-Perez, L. Gonzalez-Garcia, N. Flacco, A. Taberner-Cortes, I. Garcia-Arnandis, G. Perez-Lopez, A. Pellin-Carcelen, C. Roma-Mateo
Summary: This study aimed to analyze the impact of traditional and virtual laboratories in basic science subjects in health sciences degrees. The results indicated statistically significant differences in favor of traditional laboratories in terms of satisfaction, motivation, and academic performance, with some differences between male and female students. These findings highlight the importance of hands-on experiments to enhance student motivation and perceived performance.
JOURNAL OF BIOLOGICAL EDUCATION
(2023)
Article
Pharmacology & Pharmacy
Hernan Ramos, Juan Pardo, Rafael Sanchez, Esteve Puchades, Jordi Perez-Tur, Andres Navarro, Lucrecia Moreno
Summary: The project promoting early detection of cognitive impairment through close collaboration between community pharmacists and physicians resulted in significantly higher rates of referral to neurology and confirmed diagnosis of CI in the IPC group compared to the NonIPC group. This highlights the importance of interprofessional collaboration in improving patient outcomes related to cognitive impairment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ana Santos-Coquillat, Maria Isabel Gonzalez, Agustin Clemente-Moragon, Mario Gonzalez-Arjona, Virginia Albaladejo-Garcia, Hector Peinado, Javier Munoz, Pilar Ximenez Embun, Borja Ibanez, Eduardo Oliver, Manuel Desco, Beatriz Salinas
Summary: Exosomes, as cell-derived nanovesicles, have emerged as novel platforms for therapy and diagnosis due to their natural origin and liposome-like structure. Goat milk exosomes have been successfully isolated, labeled, and used to detect inflammatory processes in healthy mice, showing promising potential as natural probes for inflammation detection.
Article
Health Care Sciences & Services
Hernan Ramos, Lucrecia Moreno, Jordi Perez-Tur, Consuelo Chafer-Pericas, Gemma Garcia-Lluch, Juan Pardo
Summary: The increase in life expectancy has led to a higher use of medication, particularly for chronic diseases. Polypharmacy can cause medication-related issues, such as an increase in anticholinergic burden. This paper introduces a new anticholinergic burden scale, CALS, which includes more drugs with anticholinergic properties compared to the currently most used ACB scale. The study shows that the new CALS scale is more effective in assessing the relationship between anticholinergic burden and cognitive impairment, compared to the ACB scale.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Teresa Lopez de Coca, Lucrecia Moreno, Monica Alacreu, Maria Sebastian-Morello
Summary: Increasing technological advances have led to a group of digitally excluded vulnerable people who lack basic digital skills. This study aimed to assess the digital divide in patients in relation to healthcare. Findings showed that age, education level, and population location influenced the digital health divide, with lower education levels requiring more assistance, higher education levels and urban residents searching more for new treatment information, and peripheral residents receiving more help from pharmacists.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Agustin Clemente-Moragon, Eduardo Oliver, Daniel Calle, Lorena Cusso, Monica Gomez, Jesus M. Pradillo, Raquel Castejon, Norma Rallon, Jose M. Benito, Jose C. Fernandez-Ferro, Joaquin Carneado-Ruiz, Maria A. Moro, Javier Sanchez-Gonzalez, Valentin Fuster, Marta Cortes-Canteli, Manuel Desco, Borja Ibanez
Summary: By targeting neutrophil beta(1) adrenoceptors (beta 1AR), cerebral damage in patients with ischaemic stroke can be improved, providing a novel therapeutic strategy.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Cristina Garcia, Lucrecia Moreno, Monica Alacreu, Francisco J. Munoz, Luis A. Martinez
Summary: In this study, a data collection booklet (DeCo-B) was designed and piloted to assess cognitive impairment (CI) and healthy aging (HA) from a holistic perspective. The results showed associations between meaning in life domains and psychosocial variables, and identified several factors that are significantly associated with an increased risk of CI, including age, marital status, purpose in life, resilience, chronic pain, cognitive reserve, and obstructive sleep apnea.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Andres Pun-Garcia, Agustin Clemente-Moragon, Rocio Villena-Gutierrez, Monica Gomez, David Sanz-Rosa, Anabel Diaz-Guerra, Belen Prados, Juan Pablo Medina, Fermi Monto, Maria Dolores Ivorra, Cristina Marquez-Lopez, Alessandro Cannavo, Juan A. Bernal, Walter J. Koch, Valentin Fuster, Jose Luis de la Pompa, Eduardo Oliver, Borja Ibanez
Summary: This study suggests that beta 3AR overexpression may be beneficial in treating HF induced by AS, indicating a potential therapeutic strategy.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sana Ayyoub, Ramon Orriols, Eduardo Oliver, Olga Tura Ceide
Summary: Occlusions in blood vessels caused by blood clots, known as thrombosis, and their consequences contribute significantly to global morbidity and mortality. In vitro and in vivo thrombosis models have enhanced our understanding of the intricate pathways involved in its development and facilitated the evaluation of potential therapeutic approaches. This review provides an overview of commonly used methods to induce thrombosis in vivo and in vitro, without delving into specific protocols or mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Irene Martin de Miguel, Alejandro Cruz-Utrilla, Eduardo Oliver, Pilar Escribano-Subias
Summary: Pulmonary arterial hypertension (PAH) is a severe condition with a high mortality rate. Despite advances in diagnostic and therapeutic strategies, current treatments mainly focus on pulmonary vasodilation and do not address the pathological changes in the pulmonary vasculature. This review discusses the molecular mechanisms involved in PAH, the development of novel therapeutic compounds, and their potential role in future PAH treatment algorithms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jessica Segales, Carlos Sanchez-Martin, Aleida Pujol-Morcillo, Marta Martin-Ruiz, Patricia de los Santos, Daniel Lobato-Alonso, Eduardo Oliver, Eduardo Rial
Summary: The role of UCP2 in energy metabolism and cell proliferation in lung adenocarcinoma cells was investigated. The results show that UCP2 silencing decreases basal respiration and cell proliferation, suggesting its involvement in metabolic adaptations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Gemma Garcia-Lluch, Carmen Pena-Bautista, Lucrecia Moreno Royo, Miguel Baquero, Antonio Jose Canada-Martinez, Consuelo Chafer-Pericas
Summary: This case-control study examines the role of antihypertensive medication in the prevention of Alzheimer's Disease (AD). The results suggest that angiotensin II receptor blockers may play a potential role in neuroprotection and AD prevention.
Review
Dentistry, Oral Surgery & Medicine
Martin Perez-Leal, Marta Scanferla, Maria Carmen Carceller, Nicla Flacco
Summary: This study systematically reviewed the efficacy of stem cells in bone regeneration in patients with alveolar bone atrophy. The results showed that although there were differences in the application methods and outcomes of stem cells in clinical trials, overall favorable results were achieved in bone regeneration. However, the study also highlighted the limitations of stem cell therapy in bone regeneration, including scarce scientific literature, a lack of follow-up studies, and a lack of standardized protocols.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2023)
Article
Humanities, Multidisciplinary
Eva Ortega-Paino, Eduardo Oliver
REVISTA DE OCCIDENTE
(2021)