Translational Success Stories: Angiotensin Receptor 1 Antagonists in Heart Failure

Mast Cells

(2011) Jesper Swedenborg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

(2011) Scott D. Solomon et al.   EUROPEAN HEART JOURNAL

Cation dyshomeostasis and cardiomyocyte necrosis: the Fleckenstein hypothesis revisited

(2011) B. J. Borkowski et al.   EUROPEAN HEART JOURNAL

Determination of the Exact Molecular Requirements for Type 1 Angiotensin Receptor Epidermal Growth Factor Receptor Transactivation and Cardiomyocyte Hypertrophy

(2011) Nicola J. Smith et al.   HYPERTENSION

Uptake and Metabolism of the Novel Peptide Angiotensin-(1-12) by Neonatal Cardiac Myocytes

(2011) Sarfaraz Ahmad et al.   PLoS One

Angiotensin-Converting Enzyme Inhibitor Associated Cough: Deceptive Information from the Physicians' Desk Reference

(2010) Sripal Bangalore et al.   AMERICAN JOURNAL OF MEDICINE

β-Arrestin 1 and 2 stabilize the angiotensin II type I receptor in distinct high-affinity conformations

(2010) SJ Sanni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts

(2010) J. H. M. van Esch et al.   CARDIOVASCULAR RESEARCH

Chymase Inhibition Prevents Fibronectin and Myofibrillar Loss and Improves Cardiomyocyte Function and LV Torsion Angle in Dogs With Isolated Mitral Regurgitation

(2010) Betty Pat et al.   CIRCULATION

Mineralocorticoid Accelerates Transition to Heart Failure With Preserved Ejection Fraction Via “Nongenomic Effects”

(2010) Selma F. Mohammed et al.   CIRCULATION

Non-peptide AT2-receptor agonists

(2010) U Muscha Steckelings et al.   CURRENT OPINION IN PHARMACOLOGY

Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOS

(2010) Henry Krum et al.   EUROPEAN JOURNAL OF HEART FAILURE

Dietary Sodium, Aldosterone, and Left Ventricular Mass Changes During Long-Term Inhibition of the Renin-Angiotensin System

(2010) Guilhem du Cailar et al.   HYPERTENSION

Salt and Aldosterone

(2010) Maria Czarina Acelajado et al.   HYPERTENSION

Mast cell chymase limits the cardiac efficacy of Ang I–converting enzyme inhibitor therapy in rodents

(2010) Chih-Chang Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selectively Engaging  -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

(2010) J. D. Violin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional Selectivity in Adrenergic and Angiotensin Signaling Systems

(2010) C. B. Patel et al.   MOLECULAR PHARMACOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Biased Signaling of the Angiotensin II Type 1 Receptor Can Be Mediated through Distinct Mechanisms

(2010) Marie Mi Bonde et al.   PLoS One

 -Arrestin-Biased Agonism of the Angiotensin Receptor Induced by Mechanical Stress

(2010) K. Rakesh et al.   Science Signaling

Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure

(2009) Irving H. Zucker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy

(2009) Carlos M. Ferrario et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics

(2009) H. C.G. Prosser et al.   CARDIOVASCULAR RESEARCH

Effects of Dietary Sodium Reduction on Blood Pressure in Subjects With Resistant Hypertension

(2009) Eduardo Pimenta et al.   HYPERTENSION

Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2

(2009) Jan Wysocki et al.   HYPERTENSION

Angiotensin-(1-7)-Angiotensin-Converting Enzyme 2 Attenuates Reactive Oxygen Species Formation to Angiotensin II Within the Cell Nucleus

(2009) TanYa M. Gwathmey et al.   HYPERTENSION

Therapeutic Implications of the Vasoprotective Axis of the Renin-Angiotensin System in Cardiovascular Diseases

(2009) Anderson J. Ferreira et al.   HYPERTENSION

New Physiological Concepts of the Renin-Angiotensin System From the Investigation of Precursors and Products of Angiotensin I Metabolism

(2009) Carlos M. Ferrario   HYPERTENSION

Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage

(2009) Paolo Gelosa et al.   JOURNAL OF HYPERTENSION

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

(2009) Sharon Ann Hunt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Biology of the (Pro)Renin Receptor

(2009) G. Nguyen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The past, present and future of angiotensin II type 2 receptor stimulation

(2009) U. Muscha Steckelings et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

The angiotensin II type 2 receptor in cardiovascular disease

(2009) Catherine A Lemarié et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial

(2009) Marvin A Konstam et al.   LANCET

Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats

(2008) Jewell A. Jessup et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production

(2008) Vivek P. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart

(2008) Aaron J. Trask et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin II Type 2 Receptor Stimulation

(2008) Elena Kaschina et al.   CIRCULATION

Effects of the Oral Direct Renin Inhibitor Aliskiren in Patients With Symptomatic Heart Failure

(2008) John J.V. McMurray et al.   Circulation-Heart Failure

The intracellular renin???angiotensin system: implications in cardiovascular remodeling

(2008) Rajesh Kumar et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008‡

(2008) Kenneth Dickstein et al.   EUROPEAN JOURNAL OF HEART FAILURE

Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis

(2008) Robson A. S. Santos et al.   EXPERIMENTAL PHYSIOLOGY

Serum intact parathyroid hormone levels predict hospitalisation for heart failure

(2008) T Sugimoto et al.   HEART

Prorenin and Renin-Induced Extracellular Signal-Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide

(2008) Sandra Feldt et al.   HYPERTENSION

Cardiac Overexpression of Angiotensin Converting Enzyme 2 Protects the Heart From Ischemia-Induced Pathophysiology

(2008) Shant Der Sarkissian et al.   HYPERTENSION

Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents

(2008) José A. Hernández Prada et al.   HYPERTENSION

Irbesartan in Patients with Heart Failure and Preserved Ejection Fraction

(2008) Barry M. Massie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relation of Dietary Salt and Aldosterone to Urinary Protein Excretion in Subjects With Resistant Hypertension

(2007) Eduardo Pimenta et al.   HYPERTENSION