Vascular Toxicity of Phosphate in Chronic Kidney Disease

miRNA-221 and miRNA-222 synergistically function to promote vascular calcification

(2014) N. C. W. Mackenzie et al.   CELL BIOCHEMISTRY AND FUNCTION

miR-125b/Ets1 axis regulates transdifferentiation and calcification of vascular smooth muscle cells in a high-phosphate environment

(2014) Ping Wen et al.   EXPERIMENTAL CELL RESEARCH

Direct, Acute Effects of Klotho and FGF23 on Vascular Smooth Muscle and Endothelium

(2014) Isabelle Six et al.   PLoS One

Differential Effects of Indoxyl Sulfate and Inorganic Phosphate in a Murine Cerebral Endothelial Cell Line (bEnd.3)

(2014) Andréa Stinghen et al.   Toxins

Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells

(2013) Matthew H. Crouthamel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action

(2013) Lucie Hénaut et al.   CARDIOVASCULAR RESEARCH

Loss of Memo, a novel FGFR regulator, results in reduced lifespan

(2013) Barbara Haenzi et al.   FASEB JOURNAL

Effects of sevelamer treatment on cardiovascular abnormalities in mice with chronic renal failure

(2013) Julien Maizel et al.   KIDNEY INTERNATIONAL

Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency

(2013) Rika Jimbo et al.   KIDNEY INTERNATIONAL

Cinacalcet Improves Endothelial Dysfunction and Cardiac Hypertrophy in Patients on Hemodialysis with Secondary Hyperparathyroidism

(2013) Sun Ryoung Choi et al.   NEPHRON CLINICAL PRACTICE

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

(2013) Masashi Kitagawa et al.   PLoS One

Serum Phosphate as a Risk Factor for Cardiovascular Events in People with and without Chronic Kidney Disease: A Large Community Based Cohort Study

(2013) Andrew Peter McGovern et al.   PLoS One

Effects of phosphate on vascular function under normal conditions and influence of the uraemic state

(2012) I. Six et al.   CARDIOVASCULAR RESEARCH

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease

(2012) L. Darryl Quarles   EXPERIMENTAL CELL RESEARCH

FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality

(2012) Victoria Shalhoub et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Phosphate Binders in Moderate CKD

(2012) G. A. Block et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet

(2012) Wei Ling Lau et al.   KIDNEY INTERNATIONAL

High phosphate directly affects endothelial function by downregulating annexin II

(2012) Giovana Seno Di Marco et al.   KIDNEY INTERNATIONAL

MicroRNAs that target Ca2+ transporters are involved in vascular smooth muscle cell calcification

(2012) Ting Gui et al.   LABORATORY INVESTIGATION

High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease

(2012) Wei Ling Lau et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of Calcium Acetate and Sevelamer on Vascular Function and Fibroblast Growth Factor 23 in CKD Patients: A Randomized Clinical Trial

(2011) Mahmut Ilker Yilmaz et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

miR-143 and miR-145

(2011) Ashraf Yusuf Rangrez et al.   Circulation-Cardiovascular Genetics

Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway

(2011) Yoshihiro Maekawa et al.   Geriatrics & Gerontology International

Serum Levels of Phosphorus, Parathyroid Hormone, and Calcium and Risks of Death and Cardiovascular Disease in Individuals With Chronic Kidney Disease

(2011) Suetonia C. Palmer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Serum Fibroblast Growth Factor-23 Levels and Progression of Aortic Arch Calcification in Non-Diabetic Patients on Chronic Hemodialysis

(2011) Noriko Tamei et al.   Journal of Atherosclerosis and Thrombosis

MicroRNA expression during osteogenic differentiation of human multipotent mesenchymal stromal cells from bone marrow

(2011) Jie Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma Klotho and Mortality Risk in Older Community-Dwelling Adults

(2011) R. D. Semba et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

(2011) Tamara Isakova et al.   KIDNEY INTERNATIONAL

Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice

(2011) I. G. Nikolov et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages

(2011) L. Desjardins et al.   OSTEOPOROSIS INTERNATIONAL

Adverse Effects of Simulated Hyper- and Hypo-Phosphatemia on Endothelial Cell Function and Viability

(2011) Ai Peng et al.   PLoS One

Comparative Effectiveness of Calcium-Containing Phosphate Binders in Incident U.S. Dialysis Patients

(2010) W. C. Winkelmayer et al.   Clinical Journal of the American Society of Nephrology

Fibroblast growth factor (FGF)-23 and fetuin-A in calcified carotid atheroma

(2010) Mathias Voigt et al.   HISTOPATHOLOGY

High-phosphate-induced calcification is related to SM22α promoter methylation in vascular smooth muscle cells

(2010) Addy Montes de Oca et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

(2010) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis

(2010) P. Raggi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity

(2010) T. Kusaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A network connecting Runx2, SATB2, and the miR-23a 27a 24-2 cluster regulates the osteoblast differentiation program

(2010) M. Q. Hassan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community

(2009) Majd A.I. Mirza et al.   ATHEROSCLEROSIS

Elastin Degradation Accelerates Phosphate-Induced Mineralization of Vascular Smooth Muscle Cells

(2009) Nozomu Hosaka et al.   CALCIFIED TISSUE INTERNATIONAL

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community

(2009) Emil Hagström et al.   CIRCULATION

Longitudinal Relationships among Coronary Artery Calcification, Serum Phosphorus, and Kidney Function

(2009) K. R. Tuttle et al.   Clinical Journal of the American Society of Nephrology

Dietary Phosphorus Acutely Impairs Endothelial Function

(2009) E. Shuto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A 1-Year Randomized Trial of Calcium Acetate Versus Sevelamer on Progression of Coronary Artery Calcification in Hemodialysis Patients With Comparable Lipid Control: The Calcium Acetate Renagel Evaluation-2 (CARE-2) Study

(2008) Wajeh Qunibi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE−/−) mice

(2008) Ognen Ivanovski et al.   ATHEROSCLEROSIS

Endothelial microparticles in diseases

(2008) Gilles N. Chironi et al.   CELL AND TISSUE RESEARCH

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

(2008) Chang Hyun Byon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin-Mediated Matrix Vesicle Calcification in Vascular Smooth Muscle Cells

(2008) Neal X Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum Phosphorus Levels Associate with Coronary Atherosclerosis in Young Adults

(2008) R. N. Foley et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association of Serum Phosphate with Vascular and Valvular Calcification in Moderate CKD

(2008) K. L. Adeney et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phosphorus Binders and Survival on Hemodialysis

(2008) T. Isakova et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Does Fgf23–klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?

(2008) Fahad Memon et al.   KIDNEY INTERNATIONAL

Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia

(2008) F. G. Graciolli et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

(2008) Orlando M. Gutiérrez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Short-Term Treatment with Sevelamer Increases Serum Fetuin-A Concentration and Improves Endothelial Dysfunction in Chronic Kidney Disease Stage 4 Patients

(2007) K. Caglar et al.   Clinical Journal of the American Society of Nephrology

High extracellular inorganic phosphate concentration inhibits RANK-RANKL signaling in osteoclast-like cells

(2007) Anaïs Mozar et al.   JOURNAL OF CELLULAR PHYSIOLOGY