Article
Cardiac & Cardiovascular Systems
Satomi Imanari, Yasuhiro Tomita, Satoshi Kasagi, Fusae Kawana, Yuka Kimura, Sugao Ishiwata, Koji Narui, Takatoshi Kasai
Summary: The study found a modest correlation between AHI determined by the ASV device AutoSet CS (ASC) and that calculated by polysomnography (PSG) in patients with HF and SDB. However, the ASC device tended to overestimate AHI and showed moderate agreement with PSG results.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Mahssa Karimi, Jan Hedner, Ludger Grote
Summary: Adaptive Servo Ventilation (ASV) treatment improves sleep quality, neurocognition, and daytime performance in patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR).
Article
Cardiac & Cardiovascular Systems
Mathias Baumert, Dominik Linz, Michael Pfeifer, Maria Tafelmeier, Philippe Felfeli, Michael Arzt, Sobhan S. Shahrbabaki
Summary: This study confirmed the effectiveness of adaptive servo-ventilation (ASV) in reducing hypoxaemic burden related to sleep apnoea in heart failure patients. However, a significant hypoxaemic burden remained, which was related to the severity of heart failure and may have negative implications for long-term cardiovascular outcomes.
Review
Cell Biology
Zhanhao Su, Yiwei Liu, Hao Zhang
Summary: Chronic hypoxia plays a crucial role in many cardiac diseases, affecting the heart's metabolic processes. However, the exact mechanisms of adaptive cardiac metabolism in response to chronic hypoxia are still not fully understood. New findings from animal and human studies are summarized to illustrate these mechanisms and potential treatment strategies in patients with chronic hypoxia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christoph Fisser, Lara Gall, Jannis Bureck, Victoria Vaas, Joerg Priefert, Sabine Fredersdorf, Florian Zeman, Dominik Linz, Holger Woehrle, Renaud Tamisier, Helmut Teschler, Martin R. R. Cowie, Michael Arzt
Summary: This study aimed to evaluate the effects of ASV on nocturnal ventricular arrhythmias in patients with CSA and HFrEF. The results showed that adding ASV to guideline-based medical management did not significantly affect nocturnal ventricular ectopy or tachyarrhythmia over a period of 12 months.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Jingting Wang, Naima Covassin, Tianxin Dai, Zhengyang Fan, Patiguli Yisilamu, Dance Sun, Fei Li, Jiang Xie
Summary: The effectiveness of ASV therapy in reducing cardiovascular and all-cause mortality in CSA patients remains debatable. However, ASV treatment can significantly reduce the risk of MACEs in patients with nadir nocturnal saturation <= 80%. For heart failure patients, those with LVEF > 33% or NYHA I/II classification benefit from ASV therapy in lowering MACEs risk compared to usual care.
Article
Multidisciplinary Sciences
Dena Esfandyari, Bio Maria Gheo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grueter, Melanie Annemarie Meier, Anna Christina Naeger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt
Summary: MicroRNA-365 regulates human cardiac action potential by modulating key cardiac repolarizing channels.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Soeren J. Backhaus, Torben Lange, Elisabeth F. George, Kristian Hellenkamp, Roman J. Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfuss, Tim Seidler, Andreas Schuster
Summary: Real-time cardiac magnetic resonance (RT-CMR) exercise imaging can accurately diagnose HFpEF, providing a suitable noninvasive diagnostic alternative, which may be beneficial for routine clinical use pending further multicenter studies.
Article
Cardiac & Cardiovascular Systems
Hirota Kida, Shungo Hikoso, Tatsuhiko Uruno, Shigetaka Kusumoto, Keiji Yamamoto, Hirofumi Matsumoto, Akimasa Abe, Daizo Kato, Eiji Uza, Takashi Doi, Tadashi Iwamoto, Hiroyuki Kurakami, Tomomi Yamada, Tetsuhisa Kitamura, Yuki Matsuoka, Taiki Sato, Akihiro Sunaga, Bolrathanak Oeun, Takayuki Kojima, Yohei Sotomi, Tomoharu Dohi, Katsuki Okada, Shinichiro Suna, Hiroya Mizuno, Daisaku Nakatani, Yasushi Sakata
Summary: This study aimed to investigate the effectiveness and safety of ASV therapy in real-world HFpEF patients. The results showed that the introduction of ASV therapy significantly reduced the number of HF hospitalizations in HFpEF patients, particularly in female patients, those with a BMI < 25, and those with moderate to severe tricuspid valve regurgitation.
Article
Medicine, General & Internal
Federica Valli, Francesca Bursi, Gloria Santangelo, Filippo Toriello, Andrea Faggiano, Irene Rusconi, Anna Maria Vella, Stefano Carugo, Marco Guazzi
Summary: Sacubitril/Valsartan (S/V) has potential anti-remodeling effects and improves right ventricular (RV) coupling to the pulmonary circulation. This study found that 27.6% of HFrEF patients experienced left ventricular (LV) reverse remodeling and there was a significant improvement in RV function. These findings suggest a potential long-term reverse global remodeling effect of S/V and highlight a possible direct effect of the drug on the interaction between RV and pulmonary circulation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Renaud Tamisier, Jean-Louis Pepin, Martin R. Cowie, Karl Wegscheider, Eik Vettorazzi, Anna Suling, Christiane Angermann, Marie-Pia D'Ortho, Erland Erdmann, Anita K. Simonds, Virend K. Somers, Helmut Teschler, Patrick Levy, Holger Woehrle
Summary: This sub study analyzed the effectiveness of adaptive servo ventilation (ASV) in treating central sleep apnea (CSA) in heart failure patients. The results showed that after 12 months, the ASV group had better respiratory measures compared to the control group. However, the differences in sleep measures were unlikely to be clinically significant. ASV therapy also led to an increase in periodic leg movements during sleep (PLMS), which may be associated with increased cardiovascular risk.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Medicine, General & Internal
Takashi Nagasaka, Noriaki Takama, Yoshiaki Ohyama, Norimichi Koitabashi, Shoichi Tange, Masahiko Kurabayashi
Summary: The study evaluated the effects of ASV therapy on preventing arrhythmias in HF patients due to IHD, showing that ASV therapy was effective in reducing arrhythmia incidence and improving renal function in the short term.
Article
Multidisciplinary Sciences
Leslie M. Ogilvie, Brittany A. Edgett, Simon Gray, Sally Al-Mufty, Jason S. Huber, Keith R. Brunt, Jeremy A. Simpson
Summary: The study shows that inspiration has a significant impact on diastolic pressure, but minimal effect on systolic pressure. Analyzing cardiac function by accounting for respiratory phases can increase accuracy and confidence in assessing diastolic function.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Marc W. Heidorn, Stefanie Steck, Felix Mueller, Sven-Oliver Troebs, Gregor Buch, Andreas Schulz, Soeren Schwuchow-Thonke, Alexander Schuch, Konstantin Strauch, Irene Schmidtmann, Karl J. Lackner, Tommaso Gori, Thomas Muenzel, Philipp S. Wild, Jurgen H. Prochaska
Summary: This study aimed to investigate the relationship between pulmonary function and the progression of chronic heart failure (HF). The findings showed that FEV1 was independently associated with deteriorated left ventricle function and hypertrophy, and it was a strong predictor of worsening of HF.
Review
Medicine, General & Internal
Shigehiko Ogoh, Jun Sugawara, Shigeki Shibata
Summary: Heart failure (HF) in patients may increase the risk of cognitive dysfunction and stroke due to physiological factors associated with cardiac dysfunctions affecting cerebral circulation. Reduced cerebral blood flow and abnormal autoregulation in chronic HF can lead to decreased perfusion, metabolic insufficiency, and structural deteriorations in the brain. The mechanism underlying HF-induced brain disease is still unclear, and future studies should focus on physiological factors to prevent brain disease and cardiovascular dysfunction in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)