Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Microbiology
Zala Zuzek, Lucija Raspor Dall'Olio, Katka Pohar, Alojz Ihan, Miha Moskon, Damjana Rozman, Ursa Kovac, Marjanca Starcic Erjavec
Summary: Research has shown that dysbiosis of gut microbiota can affect the circadian clock of mammalian hosts, highlighting the importance of genetic background of E. coli in influencing the host's circadian clock genes.
Review
Biochemistry & Molecular Biology
Ana Beatriz Aguiar Sanford, Leidivan Sousa da Cunha, Caio Bezerra Machado, Flavia Melo Cunha de Pinho Pessoa, Abigail Nayara dos Santos Silva, Rodrigo Monteiro Ribeiro, Fabiano Cordeiro Moreira, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Lucas Eduardo Botelho de Souza, Andre Salim Khayat, Caroline Aquino Moreira-Nunes
Summary: The circadian clock is a system that regulates physiological processes and responds to the external environment, while its disruption can lead to various diseases. Leukemia is a malignancy of the blood and bone marrow caused by alterations in cellular regulatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Michelle T. T. Chan, Annette Muttray, Dionne Sakhrani, Krista Woodward, Jin-Hyoung Kim, Kris A. Christensen, Ben F. Koop, Robert H. Devlin
Summary: Transgenic fish, such as the GH transgenic coho salmon strain, show significant differences in growth rate and phenotypes compared to wild-type fish. Sex and transgene insertion sites alter transgene expression, while estradiol levels do not directly influence transgene activity. This study highlights the impact of genetic factors and transgene insertion sites on transgene expression and phenotype.
MARINE BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryota Nakazato, Yuki Matsuda, Faryal Ijaz, Koji Ikegami
Summary: Clock genes regulate the length of primary cilia through circadian dynamics, which affects fibroblast migration. The length of primary cilia exhibits circadian oscillation and controls the migration of fibroblasts.
Article
Endocrinology & Metabolism
Birgitte Georg, Jan Fahrenkrug, Henrik L. Jorgensen, Jens Hannibal
Summary: The study revealed that VIP/VPAC2-receptor signaling is crucial for the regulation of the thyroid clock. In VPAC2-deficient mice, the amplitudes of clock gene expression were reduced by half, and the phases were advanced by about 5 hours compared to WT mice. Furthermore, the thyroid clock in both WT and VPAC2-deficient mice showed sustained and identical rhythms in both LD and DD, indicating a high degree of independence from the master SCN clock.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Yoshiaki Oda, Nana N. Takasu, Sachi N. Ohno, Yukie Shirakawa, Mitsutaka Sugimura, Takahiro J. Nakamura, Wataru Nakamura
Summary: The study found that Cry1 deficiency affects the length and stability of circadian rhythms, while a single allele of Cry2 deficiency affects the circadian rhythm. Cry1(+/-) mice showed similar circadian rhythms to wild-type mice.
NEUROSCIENCE LETTERS
(2022)
Review
Immunology
Kun Xiang, Zhiwei Xu, Yu-Qian Hu, Yi-Sheng He, Guo-Cui Wu, Tian-Yu Li, Xue-Rong Wang, Li-Hong Ding, Qin Zhang, Sha-Sha Tao, Dong-Qing Ye, Hai-Feng Pan, De-Guang Wang
Summary: Circadian rhythm plays a crucial role in immune system function, with disruptions to clock genes increasing the risk of autoimmune diseases. Research on synthetic ligands of circadian clock genes may help reduce the susceptibility and severity of autoimmune diseases.
AUTOIMMUNITY REVIEWS
(2021)
Article
Medicine, Research & Experimental
Takashi Iwamoto, Kazumasa Torimoto, Daisuke Gotoh, Sayuri Onishi, Shunta Hori, Yousuke Morizawa, Yasushi Nakai, Makito Miyake, Kiyohide Fujimoto
Summary: This study aims to investigate the circadian expression changes of bladder clock genes in Dahl salt-sensitive rats following high salt intake. The results showed that high salt intake led to lower mRNA levels and reduced amplitude of circadian expression changes in bladder clock genes. However, reducing salt intake partially restored these rhythms.
Article
Biochemistry & Molecular Biology
Xiaomeng Liu, Niuben Cao, Xinchan Liu, Yu Deng, Yu Xin, Ruobing Fu, Xirui Xin, Yubo Hou, Weixian Yu
Summary: Circadian rhythms play a crucial role in regulating the body's homeostasis, and circadian rhythm disorders can have detrimental effects on metabolic and immune functions. However, the relationship between circadian rhythm disorders and periodontitis has not been well studied. This research aimed to investigate the role of the circadian rhythm control gene BMAL1 in periodontitis. The results showed that downregulation of BMAL1 in circadian rhythm disorder-induced periodontitis led to significant alveolar bone resorption, increased osteoclast differentiation, upregulation of the inflammatory signaling molecule NF-kappa B, elevated apoptosis and oxidative stress levels in periodontal tissues. This study suggests that BMAL1 is a key regulator in periodontitis exacerbated by circadian rhythm disorders, highlighting a potential avenue for periodontitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Takashi Kitahashi, Daisuke Kurokawa, Shouzo Ogiso, Nobuo Suzuki, Hironori Ando
Summary: The study found that there were no significant diurnal or circadian changes in melanopsin gene mRNA levels in the brain of juvenile grass puffer, but a significant diurnal rhythm was observed in the mRNA levels of opn4xa in the eyes, while opn4xb showed both diurnal and circadian changes. Continuous exposure to light during the subjective night significantly increased the mRNA levels of opn4xa in the eyes at ZT24.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Cell Biology
Sabrina Klemz, Thomas Wallach, Sandra Korge, Mechthild Rosing, Roman Klemz, Bert Maier, Nicholas C. Fiorenza, Irem Kaymak, Anna K. Fritzsche, Erik D. Herzog, Ralf Stanewsky, Achim Kramer
Summary: In organisms with circadian clocks, the post-translational modifications of clock proteins, particularly phosphorylation, play a crucial role in controlling circadian rhythms. Protein phosphatase 4 (PPP4) and its regulatory subunit PPP4R2 have been identified as critical components in mammals and Drosophila, affecting the circadian system by regulating phosphorylation and transactivation activity of CLOCK/BMAL1.
GENES & DEVELOPMENT
(2021)
Editorial Material
Cell Biology
Ueli Schibler
Summary: Mammalian body cells have cell-autonomous and self-sustained circadian oscillators relying on delayed negative feedback loops in gene expression. Transcriptional activation and repression, as well as post-translational mechanisms like phosphorylation and dephosphorylation, play crucial roles in setting the pace of these timekeepers. The study by Klemz and colleagues in Genes & Development demonstrates how dephosphorylation of BMAL1 by protein phosphatase 4 (PPP4) participates in the modulation of circadian timing.
GENES & DEVELOPMENT
(2021)
Article
Cell Biology
Jin-Hyoung Kim, Rosalind A. Leggatt, Michelle Chan, Helene Volkoff, Robert H. Devlin
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Article
Genetics & Heredity
Jin-Hyoung Kim, Jong S. Leong, Ben F. Koop, Robert H. Devlin
Article
Biochemistry & Molecular Biology
Jin-Hyoung Kim, Satid Chatchaiphan, Michelle T. Crown, Samantha L. White, Robert H. Devlin
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biotechnology & Applied Microbiology
Satid Chatchaiphan, Prapansak Srisapoome, Jin-Hyoung Kim, Robert H. Devlin, Uthairat Na-Nakorn
MARINE BIOTECHNOLOGY
(2017)
Article
Environmental Sciences
Jin-Hyoung Kim, Su-Young Jeong, Pyung-Joong Kim, Hans-Uwe Dahms, Kyung-Nam Han
MARINE POLLUTION BULLETIN
(2017)
Article
Marine & Freshwater Biology
Se-Joo Kim, Jin-Hyoung Kim, Se-Jong Ju
OCEAN SCIENCE JOURNAL
(2017)
Article
Biology
Abdullah Alzaid, Jin-Hyoung Kim, Robert H. Devlin, Samuel A. M. Martin, Daniel J. Macqueen
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Fisheries
G. W. Shin, S. L. White, H. U. Dahms, H. D. Jeong, J. H. Kim
JOURNAL OF FISH DISEASES
(2014)
Article
Multidisciplinary Sciences
Bo-Mi Kim, Seunghyun Kang, Do-Hwan Ahn, Jin-Hyoung Kim, Inhye Ahn, Chi-Woo Lee, Joo-Lae Cho, Gi-Sik Min, Hyun Park
Article
Biochemistry & Molecular Biology
Seunghyun Kang, Jin-Hyoung Kim, Euna Jo, Seung Jae Lee, Jihye Jung, Bo-Mi Kim, Jun Hyuck Lee, Tae-Jin Oh, Seungshic Yum, Jae-Sung Rhee, Hyun Park
MOLECULAR ECOLOGY RESOURCES
(2020)
Article
Biochemistry & Molecular Biology
Seulah Lee, Man Hyung Koo, Dong-Won Han, Il-Chan Kim, Jun Hyuck Lee, Jeong-Hoon Kim, Razia Sultana, Sun Yeou Kim, Ui Joung Youn, Jin-Hyoung Kim
Summary: This study analyzed the fatty acid composition of different organs of two Antarctic fish species (marbled rockcod and mackerel icefish) using GC-MS. The results showed variations in the fatty acid composition between the two fish species and differences in organ specificity. Additionally, extracts from the skin and liver of marbled rockcod exhibited significant inhibitory effects on matrix metalloproteinase-1.
Article
Food Science & Technology
Seongmin Lee, Mi-Ock Baek, Sana Abdul Khaliq, Amna Parveen, Sun Yeou Kim, Jin-Hyoung Kim, Il-Chan Kim, Mee-Sup Yoon
Summary: Sarcopenia is a degenerative disease characterized by decreased muscle mass and strength, for which there is currently no effective treatment. In this study, a new metabolite from Antarctic krill was isolated and found to promote muscle regeneration by enhancing mTOR signaling. This finding suggests that the metabolite may be a potential therapeutic target for sarcopenia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Fisheries
Hokyung Song, Seungyeon Lee, Dong-Won Han, Jin-Hyoung Kim
Summary: The gut microbiome of Antarctic mackerel icefish was characterized using next-generation sequencing for the first time in this study. The microbial community composition of the intestinal wall samples was found to be different from other sample types, with a higher relative abundance of Photobacterium in the intestinal content and potential pathogens such as Escherichia, Shigella, and Pseudomonas in the intestinal wall. Unlike other marine fish species, Vibrio and Lactobacillus were nearly absent in the gut microbiome of the mackerel icefish. Functional gene profiling predicted higher relative abundance of nutrient degradation-related genes in the intestinal content and higher relative abundance of important metabolite biosynthesis-related genes, such as menaquinols, in the intestinal wall. The difference in microbial community structure between the intestinal wall and intestinal content supports niche separation and highlights the importance of collecting intestinal wall samples to understand the complete picture of the gut microbiome.
Article
Biology
Do-Hwan Ahn, Seung Chul Shin, Bo-Mi Kim, Seunghyun Kang, Jin-Hyoung Kim, Inhye Ahn, Joonho Park, Hyun Park