Emerging Roles for hnRNPs in post-transcriptional regulation: what can we learn from flies?

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function

(2013) Isabelle Draper et al.   FLY

Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins

(2013) Yingbiao Ji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Control of Translation and miRNA-Dependent Repression by a Novel Poly(A) Binding Protein, hnRNP-Q

(2013) Yuri V. Svitkin et al.   PLOS BIOLOGY

Molecular analysis and biochemical classification of TDP-43 proteinopathy

(2012) Hiroshi Tsuji et al.   BRAIN

Heterogeneous Nuclear Ribonucleoprotein F Suppresses Angiotensinogen Gene Expression and Attenuates Hypertension and Kidney Injury in Diabetic Mice

(2012) C.-S. Lo et al.   DIABETES

Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model

(2012) B. Llamusi et al.   Disease Models & Mechanisms

The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster

(2012) Anand K Singh et al.   JOURNAL OF BIOSCIENCES

Misexpression screen delineates novel genes controlling Drosophila lifespan

(2012) Donggi Paik et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization

(2012) Yingbiao Ji et al.   Nature Communications

Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila

(2012) Dennis J. Hazelett et al.   G3-Genes Genomes Genetics

Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification

(2012) S. M. McDermott et al.   Biology Open

The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila

(2011) Subhash C. Lakhotia et al.   CHROMOSOMA

A late phase of germ plasm accumulation during Drosophila oogenesis requires Lost and Rumpelstiltskin

(2011) Kristina S. Sinsimer et al.   DEVELOPMENT

Epigenetic regulation of transcription in Drosophila

(2011) Aishwarya Swaminathan   Frontiers in Bioscience-Landmark

Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration

(2011) H. Tan et al.   HUMAN MOLECULAR GENETICS

Mechanistic Control of Carcinoembryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) Splice Isoforms by the Heterogeneous Nuclear Ribonuclear Proteins hnRNP L, hnRNP A1, and hnRNP M

(2011) Kenneth J. Dery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pleiotropic consequences of misexpression of the developmentally active and stress-inducible non-coding hsrω gene in Drosophila

(2011) Moushami Mallik et al.   JOURNAL OF BIOSCIENCES

Forty years of the 93D puff of Drosophila melanogaster

(2011) Subhash C Lakhotia   JOURNAL OF BIOSCIENCES

The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span

(2011) Ji-Wu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization

(2011) Vinay K. Godena et al.   PLoS One

Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster

(2011) B. Hartmann et al.   RNA

The ISWI Chromatin Remodeler Organizes the hsrω ncRNA–Containing Omega Speckle Nuclear Compartments

(2011) Maria C. Onorati et al.   PLoS Genetics

RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond

(2011) Keith A. Hanson et al.   Wiley Interdisciplinary Reviews-RNA

Evolution of SR protein and hnRNP splicing regulatory factors

(2011) Anke Busch et al.   Wiley Interdisciplinary Reviews-RNA

Functional diversity of the hnRNPs: past, present and perspectives

(2010) Siew Ping Han et al.   BIOCHEMICAL JOURNAL

Improved Activities of CREB Binding Protein, Heterogeneous Nuclear Ribonucleoproteins and Proteasome Following Downregulation of Noncoding hsr  Transcripts Help Suppress Poly(Q) Pathogenesis in Fly Models

(2010) M. Mallik et al.   GENETICS

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

(2010) G. P. Ritson et al.   JOURNAL OF NEUROSCIENCE

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

TAR DNA-binding protein 43 in neurodegenerative disease

(2010) Alice S. Chen-Plotkin et al.   Nature Reviews Neurology

VCP Associated Inclusion Body Myopathy and Paget Disease of Bone Knock-In Mouse Model Exhibits Tissue Pathology Typical of Human Disease

(2010) Mallikarjun Badadani et al.   PLoS One

A Drosophila model for TDP-43 proteinopathy

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

(2010) Emanuele Buratti et al.   RNA Biology

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles

(2010) A. Chaudhury et al.   RNA

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation

(2009) F. Besse et al.   GENES & DEVELOPMENT

The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)

(2009) Michael J. Strong   JOURNAL OF THE NEUROLOGICAL SCIENCES

Genome-wide Analysis of Alternative Pre-mRNA Splicing and RNA-Binding Specificities of the Drosophila hnRNP A/B Family Members

(2009) Marco Blanchette et al.   MOLECULAR CELL

Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing

(2009) Yingbiao Ji et al.   NUCLEIC ACIDS RESEARCH

DrosophilahnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of theprosperotwintron

(2009) Sumit Borah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SWI/SNF Associates with Nascent Pre-mRNPs and Regulates Alternative Pre-mRNA Processing

(2009) Anu Tyagi et al.   PLoS Genetics

Heterochromatin Protein 1 (HP1a) Positively Regulates Euchromatic Gene Expression through RNA Transcript Association and Interaction with hnRNPs in Drosophila

(2009) Lucia Piacentini et al.   PLoS Genetics

Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B

(2008) Yaowu He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Splicing, transcription, and chromatin: a ménage à trois

(2008) Eric Allemand et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Glorund interactions in the regulation of gurken and oskar mRNAs

(2008) Yossi Kalifa et al.   DEVELOPMENTAL BIOLOGY

Embryonic expression of Drosophila IMP in the developing CNS and PNS

(2008) Sidsel Kramshøj Adolph et al.   GENE EXPRESSION PATTERNS

Drosophila is an inclusive model for human diseases, growth and development

(2008) Lawrence I. Gilbert   MOLECULAR AND CELLULAR ENDOCRINOLOGY