DNA damage accumulation and repair defects in acute myeloid leukemia: implications for pathogenesis, disease progression, and chemotherapy resistance

Overcoming treatment resistance in acute promyelocytic leukemia and beyond

(2015) Tsz Kan Fung et al.   Oncotarget

shRNA screening identifies JMJD1C as being required for leukemia maintenance

(2014) P. Sroczynska et al.   BLOOD

Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response

(2014) Elda Grabocka et al.   CANCER CELL

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

(2014) M Ogrunc et al.   CELL DEATH AND DIFFERENTIATION

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

(2013) K. Cramer-Morales et al.   BLOOD

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

(2013) A. J. Deshpande et al.   BLOOD

PARP1 is required for chromosomal translocations

(2013) J. Wray et al.   BLOOD

Mixed lineage leukemia protein in normal and leukemic stem cells

(2013) Bon Ham Yip et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?

(2013) Ting Zhou et al.   EXPERIMENTAL HEMATOLOGY

Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies

(2013) T. J. Gaymes et al.   HAEMATOLOGICA

Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia

(2013) L L Yuan et al.   LEUKEMIA

XRCC1Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia

(2013) Claudia Bănescu et al.   LEUKEMIA & LYMPHOMA

Expression of Leukemia-Associated Fusion Proteins Increases Sensitivity to Histone Deacetylase Inhibitor-Induced DNA Damage and Apoptosis

(2013) L. A. Petruccelli et al.   MOLECULAR CANCER THERAPEUTICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

(2013) Francesco Lo-Coco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51

(2013) Chengzhi Xie et al.   PLoS One

XRCC1 Arg399Gln variation and leukemia susceptibility: evidence from 2,647 cases and 5,518 controls

(2013) Yi Huang et al.   TUMOR BIOLOGY

Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

(2013) Oren Ben-Ami et al.   Cell Reports

Evaluation of checkpoint kinase targeting therapy in Acute Myeloid Leukemia with complex karyotype

(2012) Christine Didier et al.   CANCER BIOLOGY & THERAPY

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo

(2012) Sylvia Takacova et al.   CANCER CELL

Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity

(2012) I. G. Cowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

(2012) T. Neff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

(2011) A. T. Nguyen et al.   BLOOD

Do reactive oxygen species play a role in myeloid leukemias?

(2011) P. S. Hole et al.   BLOOD

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

(2011) F. G. Rucker et al.   BLOOD

DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

(2011) Cedric Blanpain et al.   Cell Stem Cell

Transcriptional and epigenetic networks in haematological malignancy

(2011) Ngai Cheung et al.   FEBS LETTERS

EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies

(2011) M.-Y. Cai et al.   GUT

RAD51 and XRCC3 polymorphisms: Impact on the risk and treatment outcomes of de novo inv(16) or t(16;16)/CBFβ–MYH11(+) acute myeloid leukemia

(2011) Liang Liu et al.   LEUKEMIA RESEARCH

DNA damage response in adult stem cells: pathways and consequences

(2011) Pankaj K. Mandal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Connection between Rad51 and PML in Homology-Directed Repair

(2011) Sergei Boichuk et al.   PLoS One

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy

(2010) J. Fan et al.   BLOOD

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials

(2010) D. Grimwade et al.   BLOOD

Acute leukemia in children with Down syndrome

(2010) A. C. Xavier et al.   HAEMATOLOGICA

Acute myeloid leukemia outcome: role of nucleotide excision repair polymorphisms in intermediate risk patients

(2010) Sara S. Strom et al.   LEUKEMIA & LYMPHOMA

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NHEJ and its backup pathways in chromosomal translocations

(2010) Michael R Lieber   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells

(2009) P. S. Hole et al.   BLOOD

Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy

(2009) C. Cavelier et al.   CANCER RESEARCH

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

(2009) H. Boukarabila et al.   GENES & DEVELOPMENT

Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes

(2009) T. J. Gaymes et al.   HAEMATOLOGICA

The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia

(2009) H Seifert et al.   LEUKEMIA

Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity

(2009) T. M. Horton et al.   MOLECULAR CANCER THERAPEUTICS

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

OGG1 is a novel prognostic indicator in acute myeloid leukaemia

(2009) K Liddiard et al.   ONCOGENE

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS

Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression

(2008) Guogen Mao et al.   CELL RESEARCH

Chromosomal instability syndromes are sensitive to poly ADP-ribose polymerase inhibitors

(2008) T. J. Gaymes et al.   HAEMATOLOGICA