Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1

(2015) Cynthia A. Morgan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors

(2015) Cynthia A. Morgan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma

(2015) Lili Yue et al.   MELANOMA RESEARCH

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985

(2015) Ronald C. Elgersma et al.   MOLECULAR PHARMACEUTICS

Development of Selective Inhibitors for Aldehyde Dehydrogenases Based on Substituted Indole-2,3-diones

(2014) Ann C. Kimble-Hill et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

(2013) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment

(2013) Moana Tercel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Duocarmycin Analogues without a DNA-Binding Indole Unit Associate with Aldehyde Dehydrogenase 1A1 and not DNA: A Reply

(2013) Lutz F. Tietze et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

(2012) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomolecular Simulation: A Computational Microscope for Molecular Biology

(2012) Ron O. Dror et al.   Annual Review of Biophysics

Rethinking the term “pi-stacking”

(2012) Chelsea R. Martinez et al.   Chemical Science

Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform

(2011) Paola Marcato et al.   CELL CYCLE

The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance

(2011) Jan S. Moreb et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases

(2011) May Khanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosidic Prodrugs of Highly Potent Bifunctional Duocarmycin Derivatives for Selective Treatment of Cancer

(2010) Lutz F. Tietze et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing the Mechanism of Action of Potential Anticancer Agents at a Molecular Level Using Electrospray Ionisation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2009) Lutz F. Tietze et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

Hydrogen Bonding and π-Stacking: How Reliable are Force Fields? A Critical Evaluation of Force Field Descriptions of Nonbonded Interactions

(2009) Robert S. Paton et al.   Journal of Chemical Information and Modeling

Fundamental Relationships between Structure, Reactivity, and Biological Activity for the Duocarmycins and CC-1065

(2009) Karen S. MacMillan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determination of the Biological Activity and Structure Activity Relationships of Drugs Based on the Highly Cytotoxic Duocarmycins and CC-1065

(2009) Lutz Tietze et al.   Toxins