The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

(2012) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Analogues of CC-1065 and the Duocarmycins for the Use in Targeted Tumour Therapies

(2012) Lutz Tietze et al.   Anti-Cancer Agents in Medicinal Chemistry

Photoactivatable Prodrugs of Highly Potent Duocarmycin Analogues for a Selective Cancer Therapy

(2012) Lutz F. Tietze et al.   CHEMISTRY-A EUROPEAN JOURNAL

Low expression of aldehyde deyhdrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer

(2011) Christoph Kahlert et al.   BMC CANCER

The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance

(2011) Jan S. Moreb et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis and Biological Evaluation of Prodrugs Based on the Natural Antibiotic Duocarmycin for Use in ADEPT and PMT

(2011) Lutz F. Tietze et al.   CHEMISTRY-A EUROPEAN JOURNAL

Prodrugs for Targeted Tumor Therapies: Recent Developments in ADEPT, GDEPT and PMT

(2011) Lutz F. Tietze et al.   CURRENT PHARMACEUTICAL DESIGN

Glycosidic Prodrugs of Highly Potent Bifunctional Duocarmycin Derivatives for Selective Treatment of Cancer

(2010) Lutz F. Tietze et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies

(2010) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

(2010) C. N. Landen et al.   MOLECULAR CANCER THERAPEUTICS

Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression

(2009) Koji Morimoto et al.   CANCER SCIENCE

Antibody-Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies

(2009) Lutz F. Tietze et al.   Chemical Biology & Drug Design

Targeting: The ADEPT Story So Far

(2009) K. Bagshawe   CURRENT DRUG TARGETS

Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer

(2009) F. Jiang et al.   MOLECULAR CANCER RESEARCH

Activity-based probes as a tool for functional proteomic analysis of proteases

(2008) Marko Fonović et al.   Expert Review of Proteomics

ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells

(2008) Jan S Moreb et al.   Molecular Cancer

Prodrug Strategies in Anticancer Chemotherapy

(2007) Felix Kratz et al.   ChemMedChem