Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jingnan Liao, Yuan Li, Xiaofeng Li, Xian Su, Jing Peng, Na Xiao, Xiangxiu Fan, Huijun Chen, Guangxiu Lu, Ge Lin, Lamei Cheng, Fei Gong
Summary: The study found that pre-pregnancy blood Treg levels were significantly lower in URPL patients than in controls, and that Treg levels predicted subsequent miscarriages. There were no significant differences among other blood cell types between the two groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Oncology
Laurene Pousse, Koorosh Korfi, Bruno C. C. Medeiros, Marco Berrera, Nadine Kumpesa, Jan Eckmann, Idil Karakoc Hutter, Vera Griesser, Vaios Karanikas, Christian Klein, Maria Amann
Summary: By analyzing the bone marrow and/or blood samples of 37 AML patients and healthy donors, it was found that the composition of the bone marrow is strongly correlated with that of the blood. CD25 expressing AML cells were found to be enriched in FLT3-ITD mutation patients and patients treated with a hypomethylating agent in combination with venetoclax. CD25 Mab antibody can specifically kill CD25+ AML cells and regulatory T cells, providing a potential treatment for leukemia.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Florianne M. J. Hafkamp, Esther W. M. Taanman-Kueter, Toni M. M. van Capel, Tom Groot Kormelink, Esther C. de Jong
Summary: This study investigated the effects of Vitamin D3 on the differentiation of specific human T cells. The results showed that Vitamin D3 can restrict the development of Th17 cells, promote the development of regulatory T cells, and reduce the production of specific cytokines by dendritic cells. This provides potential for the use of Vitamin D3 as an adjuvant in the treatment of autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
Summary: In this study, the deficiency of CD1d-restricted iNKT cells was found to lead to the expansion of Foxp3(-)CD25(+)CD4(+) T cells in colitis. The MLN dendritic cells in DSS-treated Yeti/CD1d KO mice were shown to promote the differentiation of these cells. Furthermore, Foxp3(-)CD25(+)CD4(+) T cells were found to be pathogenic in DSS-treated Yeti/CD1d KO mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi
Summary: Regulatory T cells (Tregs) in tumor tissues can be selectively targeted to enhance anti-tumor immune responses, while maintaining immune homeostasis in healthy organs. Current strategies such as immune checkpoint blockade (ICB) antibodies and differential targeting of surface and intracellular molecules show promise in this regard. Combining Treg targeting with ICB antibodies may enhance the efficacy of cancer immunotherapy.
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiufang Cui, Ziping Ye, Di Wang, Yan Yang, ChunHua Jiao, Jingjing Ma, Nana Tang, Hongjie Zhang
Summary: This study found that activation of AhR in DCs can induce tolerogenic DCs, promote Treg cell differentiation, and alleviate the severity of intestinal inflammation. Transplanted tolDCs can also maintain the balance of Th17/Treg differentiation. Therefore, AhR may be a potential therapeutic target for CD.
CELL AND BIOSCIENCE
(2022)
Article
Immunology
Bruce M. Hall, Rachael M. Hall, Giang T. Tran, Catherine M. Robinson, Paul L. Wilcox, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Suzanne J. Hodgkinson
Summary: The CD4(+)CD25(+)Foxp3(+)T cell population is heterogeneous, consisting of three major subgroups with different functions and characteristics. Treatment with rIL-5 can prevent rejection of transplants by activating Ts2 cells and Th2-like Treg. This therapeutic approach significantly improves survival rates and reduces rejection reactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qifeng Ou, Rachael Power, Matthew D. Griffin
Summary: Regulatory T cells (Treg) play a critical role in maintaining immune homeostasis and have direct modulatory effects on innate immune responses in various acute and chronic diseases. Therapeutic interventions aimed at enhancing Treg numbers or potency show promising outcomes in autoimmunity and allogeneic transplants. Furthermore, interactions between Treg and innate immune effectors significantly impact disease severity and treatment. Treg-based therapeutic strategies hold potential for globally impactful inflammatory conditions such as type 2 diabetes, ischemia reperfusion injury, and atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Linda M. Lee, Hong Zhang, Karim Lee, Horace Liang, Alexander Merleev, Flavio Vincenti, Emanual Maverakis, Angus W. Thomson, Qizhi Tang
Summary: In this study comparing arTregs expanded ex vivo using different types of antigen-presenting cells, it was found that sDCs stimulated Tregs to expand in much larger numbers. Additionally, sDC-generated arTregs expressed higher levels of CD80, CD86, and T cell-attracting chemokines, indicating their superior expansion-inducing capacity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Priyanka Devi-Marulkar, Solene Fastenackels, Pierre Karapentiantz, Jeremy Goc, Claire Germain, Helene Kaplon, Samantha Knockaert, Daniel Olive, Marylou Panouillot, Pierre Validire, Diane Damotte, Marco Alifano, Juliette Murris, Sandrine Katsahian, Myriam Lawand, Marie-Caroline Dieu-Nosjean
Summary: Regulatory T cells (Tregs) play a role in tumor immunity, but Tregs in tertiary lymphoid structures (TLS) have similar immune characteristics to those in non-TLS areas. Tumor-infiltrating Tregs inhibit conventional T cell proliferation, but this inhibition can be restored by antibodies against CTLA-4 and GITR. Tregs in the whole tumor are associated with a poor outcome in NSCLC patients, while combined use with TLS-DCs and CD8(+) T cells improves overall survival.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Qianqian Yang, Meihui Li, Ming Zhao, Feifan Lu, Xiaomin Yu, Li Li, Zhongyi Gu, Yifang Deng, Rui Guan
Summary: This study found that progesterone supplementation can promote pregnancy immune homeostasis by up-regulating Treg cells and TGF-beta 1 expression, which may be one of the mechanisms for preventing spontaneous preterm birth (sPTB).
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Wang, Jin-Ling Yi, Hai-Yan Chen, Pei-Liang Wang, Yan-Li Shen
Summary: The study revealed that in VLS patients, the levels of Foxp3 protein were reduced while DNMT1 and DNMT3b proteins were increased in lesional skin. Certain CpG sites in the Foxp3 promoter region showed higher methylation rates in VLS patients. The number of CD4 + CD25 + CD127low Tregs decreased significantly, potentially causing abnormal immunosuppression and leading to VLS.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)