Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yannick D. Muller, Leonardo M. R. Ferreira, Emilie Ronin, Patrick Ho, Vinh Nguyen, Gaetano Faleo, Yu Zhou, Karim Lee, Kevin L. Leung, Nikolaos Skartsis, Anupurna M. Kaul, Arend Mulder, Frans H. J. Claas, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang
Summary: The study demonstrates that genome-engineered mono-antigen-specific A2-CAR Tregs can localize to HLA-A2-expressing grafts and exhibit antigen-dependent in vivo suppression. These Tregs do not impair the function of islets and can delay graft-versus-host disease. This approach may be applied towards developing precision Treg cell therapies for transplant tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi
Summary: Regulatory T cells (Tregs) in tumor tissues can be selectively targeted to enhance anti-tumor immune responses, while maintaining immune homeostasis in healthy organs. Current strategies such as immune checkpoint blockade (ICB) antibodies and differential targeting of surface and intracellular molecules show promise in this regard. Combining Treg targeting with ICB antibodies may enhance the efficacy of cancer immunotherapy.
Review
Immunology
Jian Lu, Peiyuan Li, Xuezhi Du, Yanhong Liu, Baotong Zhang, Feng Qi
Summary: Regulatory T cells (Tregs) are promising research targets for inducing immune tolerance in organ transplantation, and Treg-based cellular therapies have shifted towards clinical trials for transplantation.
TRANSPLANT IMMUNOLOGY
(2021)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Esther Bernaldo-de-Quiros, Manuela Camino, Marta Martinez-Bonet, Juan Miguel Gil-Jaurena, Nuria Gil, Diana Hernandez-Florez, Maria Eugenia Fernandez-Santos, Laura Butragueno, I. Esme Dijke, Megan K. Levings, Lori J. West, Marjorie Pion, Rafael Correa-Rocha
Summary: This study developed a new approach to obtain large quantities of high-purity Tregs from routine surgeries, which could be used for cellular therapy to prevent transplant rejection. The initial results of the clinical trial showed that the administration of thyTregs in infants undergoing heart transplantation had no adverse effects and maintained a stable Treg frequency in the peripheral blood.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Immunology
Guirong Liu, Manman Liu, Junjuan Wang, Yao Mou, Huilian Che
Summary: The increasing prevalence of food allergies has spurred research on novel treatment strategies like EPIT, which has shown potential in inducing immune tolerance. Treg cells play a key role in immune tolerance induced by EPIT but further exploration is needed to understand its mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qifeng Ou, Rachael Power, Matthew D. Griffin
Summary: Regulatory T cells (Treg) play a critical role in maintaining immune homeostasis and have direct modulatory effects on innate immune responses in various acute and chronic diseases. Therapeutic interventions aimed at enhancing Treg numbers or potency show promising outcomes in autoimmunity and allogeneic transplants. Furthermore, interactions between Treg and innate immune effectors significantly impact disease severity and treatment. Treg-based therapeutic strategies hold potential for globally impactful inflammatory conditions such as type 2 diabetes, ischemia reperfusion injury, and atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Kumar Abhishek, Malavika Nidhi, Srinandhini Chandran, Sergey S. Shevkoplyas, Chandra Mohan
Summary: Regulatory T cells (Tregs) are a type of lymphocyte that regulate the immune system by suppressing unwanted immune responses, preventing autoimmune diseases and inappropriate inflammatory reactions. They have shown promise in preventing graft vs. host disease, alleviating autoimmune symptoms, and promoting transplant tolerance. This review provides an overview of Treg cells, including important markers and subsets, as well as the methodology used for manufacturing adoptive regulatory T cell therapies (TRACT). The approaches and outcomes of several clinical trials involving adoptive transfer of Tregs to patients are also discussed.
CLINICAL IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Christian Morath, Matthias Schaier, Eman Ibrahim, Lei Wang, Christian Kleist, Gerhard Opelz, Caner Suesal, Gerald Ponath, Mostafa Aly, Cristiam M. Alvarez, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Thuong Hien Tran, Sabine Scherer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: This study shows that using donor-derived modified immune cells (MICs)-PBMCs for specific immunosuppression treatment before kidney transplantation can result in an increase in CD19(+)CD24(hi)CD38(hi) transitional B lymphocytes by up to 68-fold compared to transplanted controls.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)