Phosphatase PTPN4 Preferentially Inhibits TRIF-Dependent TLR4 Pathway by Dephosphorylating TRAM

Tyrosine phosphorylation in Toll-like receptor signaling

(2014) Saurabh Chattopadhyay et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

(2014) Wanwan Huai et al.   Nature Communications

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

(2013) Yaya Wang et al.   IMMUNITY

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Protein Tyrosine Phosphatase with Proline-Glutamine-Serine-Threonine-Rich Motifs Negatively Regulates TLR-Triggered Innate Responses by Selectively Inhibiting I B Kinase  /NF- B Activation

(2013) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling

(2013) Y. Enokizono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

E3 Ubiquitin Ligase Tripartite Motif 38 Negatively Regulates TLR-Mediated Immune Responses by Proteasomal Degradation of TNF Receptor-Associated Factor 6 in Macrophages

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

(2012) Inmoo Rhee et al.   NATURE IMMUNOLOGY

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation

(2012) Sarah L. Doyle et al.   Nature Communications

Peptides Targeting the PDZ Domain of PTPN4 Are Efficient Inducers of Glioblastoma Cell Death

(2011) Nicolas Babault et al.   STRUCTURE

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway

(2009) Eva M Palsson-McDermott et al.   NATURE IMMUNOLOGY

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions

(2008) Jennifer A. Young et al.   MOLECULAR IMMUNOLOGY

Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages

(2008) Hongmei Xu et al.   MOLECULAR IMMUNOLOGY

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY