Article
Immunology
Gerardo Suarez-Rojas, Jose C. Crispin
Summary: This review summarizes the kinase and phosphatase defects in T cells from patients with SLE and discusses their significance for disease development and expression.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Andrew Getahun
Summary: This review article focuses on the B cell-intrinsic mechanisms that prevent the activation of autoreactive B cells in the periphery. It discusses the establishment of inhibitory signaling circuits, specifically the Lyn-SHIP-1-SHP-1 axis, and how disruptions of these circuits can contribute to the development of autoimmunity.
IMMUNOLOGICAL REVIEWS
(2022)
Review
Medicine, General & Internal
Jiawen Chen, Yafei Li, Chong Du, Tianwen Wei, Tiankai Shan, Liansheng Wang
Summary: Protein kinases play a crucial role in cardiovascular diseases and their study is of great significance for heart repair and treatment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Cell & Tissue Engineering
Junqing Li, Zhihua Wang, Juan Wang, Qian Guo, Yi Fu, Zihan Dai, Minghao Wang, Yu Bai, Xin Liu, Paul R. Cooper, Jiayuan Wu, Wenxi He
Summary: The study found that AREG promoted odontoblastic differentiation in dental pulp stem cells, facilitating regeneration and mineralization processes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Mathilde Soulez, Pierre-Luc Tanguay, Florence Do, Junio Dort, Colin Crist, Alexey Kotlyarov, Matthias Gaestel, Mathieu Ferron, Nicolas A. Dumont, Sylvain Meloche
Summary: The ERK3 and its substrate MK5 constitute a signaling pathway that plays an important regulatory role in postnatal muscle differentiation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hui-Liang Zhang, Xiao-Chuan Wang, Rong Liu
Summary: Zinc is crucial for human growth and development, particularly in regulating the mechanisms of neurodegenerative diseases.
Review
Medicine, Research & Experimental
Xia Zhao, Li Xiong, Lingyu She, Liwei Li, Ping Huang, Guang Liang
Summary: Protein tyrosine phosphatases (PTPs) play a significant role in the pathogenesis of Alzheimer's disease (AD) and are closely related to the accumulation of abnormally phosphorylated proteins.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Malathi Bheri, Swati Mahiwal, Sibaji K. Sanyal, Girdhar K. Pandey
Summary: Protein phosphorylation and dephosphorylation are important reversible post-translational modifications, with protein phosphatases playing a key role in signaling networks. The classification and mechanism of phosphatases in plant systems still require further investigation.
Review
Immunology
Feiling Xie, Hongmei Dong, Hao Zhang
Summary: PTPRO/PTPROt, as a member of the PTP family, plays a crucial role in immune cells by regulating their growth, differentiation, activation and immune responses. This review focuses on the regulatory roles and molecular mechanisms of PTPRO/PTPROt in B cells, T cells, and macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Inga Peciuliene, Egle Jakubauskiene, Laurynas Vilys, Ruta Zinkeviciute, Kotryna Kvedaraviciute, Arvydas Kanopka
Summary: This article investigates the effects of short-term hypoxia on gene splicing and protein expression. The study found that the splicing of genes associated with cellular stress changes under short-term hypoxic conditions, but differs from that under prolonged hypoxia. Additionally, short-term cellular hypoxia increases protein phosphatase expression, which is important for altering gene splicing.
Article
Cell & Tissue Engineering
Xueyue Wang, Yan Ruan, Junlei Zhang, Yanping Tian, Lianlian Liu, JiaLi Wang, Gaoke Liu, Yuda Cheng, Yixiao Xu, Yi Yang, Meng Yu, Binyu Zhao, Yue Zhang, Jiaqi Wang, Jiangjun Wang, Wei Wu, Ping He, Lan Xiao, Jiaxiang Xiong, Rui Jian
Summary: The study identifies two Yap splicing isoforms in ESCs with different distributions and effects on self-renewal and differentiation potential, with Yap472 playing a more essential role in neuroectoderm differentiation.
Article
Multidisciplinary Sciences
Xiaoyu Guo, Xue Ding, Juan Dong
Summary: In this study, the authors found that BSL proteins in Arabidopsis have different functions in the cell cortex and nucleus, regulating stomatal formation through the activation or deactivation of different signaling pathways.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yongjian Yang, Guanxun Li, Yan Zhong, Qian Xu, Bo-Jia Chen, Yu-Te Lin, Robert S. Chapkin, James J. Cai
Summary: In this paper, the authors present GenKI, a virtual knockout tool for gene function prediction using scRNA-seq data. GenKI captures shifting patterns in gene regulation caused by knockout perturbations and provides a robust framework for gene function studies. By adapting a VGAE model, GenKI learns latent representations of genes and interactions between genes from input scRNA-seq data and a derived scGRN. Virtual knockout data is generated by computationally removing edges corresponding to the knockout gene from the scGRN. GenKI accurately approximates perturbation profiles and outperforms existing methods in simulations. It also recapitulates discoveries of real-animal knockout experiments and predicts cell type-specific functions of knockout genes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Emmanuel Baudouin, Juliette Puyaubert, Patrice Meimoun, Melisande Blein-Nicolas, Marlene Davanture, Michel Zivy, Christophe Bailly
Summary: This study investigated the remodeling of Arabidopsis seed phosphoproteome during imbibition using stable isotope dimethyl labeling and nanoLC-MS/MS analysis. The study identified a large repertoire of phosphopeptides and phosphoproteins involved in seed germination control, including protein kinases and key regulators like DOG1. Gene ontology analysis revealed their involvement in various biological processes. The study provides evidence of the major role of phosphosignaling in the regulation of Arabidopsis seed germination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Naoki Ichikawa-Tomikawa, Kotaro Sugimoto, Korehito Kashiwagi, Hideki Chiba
Summary: Cell adhesion molecules, including integrins, cadherins, and claudins, activate Src-family kinases (SFKs), but the underlying molecular mechanism is unclear. This study found that CLDN6 interacts with SFK members, BLK and SRC, via their cytoplasmic domains. BLK and SRC play a crucial role in CLDN6-triggered cellular events.
Article
Medicine, Research & Experimental
Lindley Maryoung, Yangbo Yue, Ashley Young, Chad A. Newton, Cindy Barba, Nicolai S. C. van Oers, Richard C. Wang, Christine Kim Garcia
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Cell Biology
Qiumei Du, Ashley R. Hoover, Igor Dozmorov, Prithvi Raj, Shaheen Khan, Erika Molina, Tsung-Cheng Chang, Maria Teresa de la Morena, Ondine B. Cleaver, Joshua T. Mendell, Nicolai S. C. van Oers
DEVELOPMENTAL CELL
(2019)
Article
Medicine, Research & Experimental
Qiumei Du, Larry K. Huynh, Fatma Coskun, Erika Molina, Matthew A. King, Prithvi Raj, Shaheen Khan, Igor Dozmorov, Christine M. Seroogy, Christian A. Wysocki, Grace T. Padron, Tyler R. Yates, M. Louise Markert, M. Teresa de la Morena, Nicolai S. C. van Oers
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Review
Genetics & Heredity
Qiumei Du, M. Teresa de la Morena, Nicolai S. C. van Oers
FRONTIERS IN GENETICS
(2020)
Review
Immunology
Pratibha Bhalla, Christian A. Wysocki, Nicolai S. C. van Oers
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Microbiology
Fatma S. Coskun, Shashikant Srivastava, Prithvi Raj, Igor Dozmorov, Serkan Belkaya, Smriti Mehra, Nadia A. Golden, Allison N. Bucsan, Moti L. Chapagain, Edward K. Wakeland, Deepak Kaushal, Tawanda Gumbo, Nicolai S. C. van Oers
FRONTIERS IN MICROBIOLOGY
(2020)
Editorial Material
Immunology
Nicolai S. C. van Oers, Dong-Ming Su, Ann P. Chidgey, Jarrod Dudakov
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Nicolai S. C. van Oers, Natasha W. Hanners, Paul K. Sue, Victor Aquino, Quan-Zhen Li, John W. Schoggins, Christian A. Wysocki
Summary: X-linked severe combined immunodeficiency (X-SCID) is a severe immune disorder caused by genetic mutations, with patients facing opportunistic infections. An infant with X-SCID contracted SARS-CoV-2 before receiving a stem cell transplant, but ultimately recovered after treatment.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Patricia Pichilingue-Reto, Prithvi Raj, Quan-Zhen Li, Igor Dozmorov, David R. Karp, Edward K. Wakeland, Morgan Nelson, Rebecca S. Gruchalla, M. Teresa de la Morena, Nicolai S. C. van Oers
Summary: The study profiled serum IgG responses in toddlers and found correlations between the magnitude of antibody responses towards viruses, live attenuated vaccines, and certain autoantigens. A low responder group had much weaker responses overall, including against vaccines. Serum antibody screen also identifies individuals with IgG responses to less common infections.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Bo Zhang, Matthew Brock, Carlos Arana, Chaitanya Dende, Nicolai Stanislas van Oers, Lora Hooper, Prithvi Raj
Summary: Bead-beating is critical for DNA extraction, influencing the accurate assessment of microbial community composition. Full length 16S rRNA gene sequencing revealed species diversity in mouse and human gut microbiomes, as well as different levels of sensitivity to bead-beating treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Pratibha Bhalla, Dong-Ming Su, Nicolai S. C. van Oers
Summary: The thymus, a primary lymphoid organ, plays a crucial role in producing T cells of the immune system. It can be damaged under certain types of systemic stresses and undergoes functional decline during aging. The microenvironment of the thymus, established through interactions between various cell types, influences thymus functions. Understanding the contributions of different stromal cell types in the thymus can inform strategies for restoring thymus functionality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Angela Moses, Pratibha Bhalla, Austin Thompson, Laijun Lai, Fatma S. Coskun, Christine M. Seroogy, Maria Teresa de la Morena, Christian A. Wysocki, Nicolai S. C. van Oers
Summary: This study investigates the impact of FOXN1 gene mutations on thymus development and T-cell output. By conducting experiments and using animal models, it was found that different FOXN1 variants have different effects on T-cell development. These findings contribute to a better understanding of the mechanisms underlying immune deficiencies associated with FOXN1 mutations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Pratibha Bhalla, Qiumei Du, Ashwani Kumar, Chao Xing, Angela Moses, Igor Dozmorov, Christian A. Wysocki, Ondine B. Cleaver, Timothy J. Pirolli, Mary Louise Markert, Maria Teresa de la Morena, Antonio Baldini, Nicolai S. C. van Ders
Summary: 22q11.2 deletion syndrome (22q11.2DS) is the most common human chromosomal microdeletion, causing thymic hypoplasia and T cell lymphopenia. This study identified that abnormal thymic mesenchymal cells were responsible for the small size of the embryonic thymuses in the 22q11.2DS mouse models, and this could be corrected by replacing them with normal mesenchyme.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Fatma S. Coskun, Przemyslaw Plocinski, Nicolai S. C. van Oers
Summary: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), with recent studies revealing the abundance of noncoding RNAs expressed by these bacteria in different growth phases and infection states. These noncoding RNAs include small RNAs and even smaller RNAs, and methodological advances like RNA sequencing strategies and specific RNA probes have advanced the study of these small RNAs. Further research is needed to fully understand the biological and pathogenic roles of these mycobacterial noncoding RNAs.
Article
Biotechnology & Applied Microbiology
Prithvi Raj, Ran Song, Honglin Zhu, Linley Riediger, Dong-Jae Jun, Chaoying Liang, Carlos Arana, Bo Zhang, Yajing Gao, Benjamin E. Wakeland, Igor Dozmorov, Jinchun Zhou, Jennifer A. Kelly, Bernard R. Lauwerys, Joel M. Guthridge, Nancy J. Olsen, Swapan K. Nath, Chandrashekhar Pasare, Nicolai van Oers, Gary Gilkeson, Betty P. Tsao, Patrick M. Gaffney, Peter K. Gregersen, Judith A. James, Xiaoxia Zuo, David R. Karp, Quan-Zhen Li, Edward K. Wakeland