Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA

Role of miRNA in the Regulation of Inflammatory Genes in Staphylococcal Enterotoxin B-Induced Acute Inflammatory Lung Injury and Mortality

(2015) Roshni Rao et al.   TOXICOLOGICAL SCIENCES

Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs

(2014) K Smigielska-Czepiel et al.   GENES AND IMMUNITY

miR-155 deficiency protects mice from experimental colitis by reducing T helper type 1/type 17 responses

(2014) Udai P. Singh et al.   IMMUNOLOGY

Expression, Regulation and Function of MicroRNAs in Multiple Sclerosis

(2014) Xinting Ma et al.   International Journal of Medical Sciences

Dysregulation in microRNA Expression Is Associated with Alterations in Immune Functions in Combat Veterans with Post-Traumatic Stress Disorder

(2014) Juhua Zhou et al.   PLoS One

Antitumoral Activity of Indole-3-carbinol Cyclic tri- and Tetrameric Derivatives Mixture in Human Breast Cancer Cells: In Vitro and In Vivo Studies

(2013) Giorgio Brandi et al.   Anti-Cancer Agents in Medicinal Chemistry

Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells

(2013) Michael Rouse et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct MicroRNA Expression Profile and Targeted Biological Pathways in Functional Myeloid-derived Suppressor Cells Induced by Δ9-Tetrahydrocannabinolin Vivo

(2013) Venkatesh L. Hegde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Influences of the Aryl Hydrocarbon Receptor on Th17 Mediated Responses in vitro and in vivo

(2013) João H. Duarte et al.   PLoS One

Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation

(2013) T. Nakahama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural indoles, indole-3-carbinol and 3,3′-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression

(2013) Philip B. Busbee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The dietary phytochemical 3,3′-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling

(2012) Jing-Ru Weng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Indole-3-Carbinol disrupts Estrogen Receptor-alpha dependent expression of Insulin-like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and proliferation of human breast cancer cells

(2012) Crystal N. Marconett et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

3,3′-Diindolylmethane Induces G1 Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

(2012) Lyndsey E. Shorey et al.   PLoS One

Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment

(2011) B Taylor-Harding et al.   BRITISH JOURNAL OF CANCER

B-DIM impairs radiation-induced survival pathways independently of androgen receptor expression and augments radiation efficacy in prostate cancer

(2011) Vinita Singh-Gupta et al.   CANCER LETTERS

MicroRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion by targeting CD40L in oxLDL-stimulated dendritic cells

(2011) Ting Chen et al.   FEBS LETTERS

Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats

(2011) Keisuke Shimamoto et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b

(2011) Riccardo L Rossi et al.   NATURE IMMUNOLOGY

Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis

(2011) Narendra P. Singh et al.   PLoS One

Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression

(2010) Akina Ishii et al.   ALLERGOLOGY INTERNATIONAL

Toxic and Chemopreventive Ligands Preferentially Activate Distinct Aryl Hydrocarbon Receptor Pathways: Implications for Cancer Prevention

(2009) S. T. Okino et al.   Cancer Prevention Research

3,3'-Diindolylmethane Induction of p75NTR-Dependent Cell Death via the p38 Mitogen-Activated Protein Kinase Pathway in Prostate Cancer Cells

(2009) F. S. Khwaja et al.   Cancer Prevention Research

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

(2009) Emily A. Stevens et al.   IMMUNOLOGY

MicroRNAs in Cancer: Small Molecules With a Huge Impact

(2009) Marilena V. Iorio et al.   JOURNAL OF CLINICAL ONCOLOGY

The aryl hydrocarbon receptor in immunity

(2009) Charlotte Esser et al.   TRENDS IN IMMUNOLOGY

MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes

(2008) M. Inomata et al.   BLOOD

Consumption of Raw Cruciferous Vegetables is Inversely Associated with Bladder Cancer Risk

(2008) L. Tang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Detection, Occurrence and Fate of Indirubin in Municipal Sewage Treatment Plants

(2008) Jianying Hu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Primary Peripheral T Cells Become Susceptible to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Mediated Apoptosis in Vitro upon Activation and in the Presence of Dendritic Cells

(2008) N. P. Singh et al.   MOLECULAR PHARMACOLOGY

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE