4.0 Article

Immune functional impacts of oyster peptide-based enteral nutrition formula (OPENF) on mice: a pilot study

Journal

CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
Volume 31, Issue 4, Pages 813-820

Publisher

SCIENCE PRESS
DOI: 10.1007/s00343-013-2311-z

Keywords

marine protein; oyster peptides; enteral nutrition formula; immunomodulation

Funding

  1. Knowledge Innovation Program of Chinese Academy of Sciences [KZCX2-EW-Q214]
  2. Marine Fisheries Technology Promotion Special Program of Guangdong Province [A2009009-035(a)]
  3. Guangdong Province [2011A090100008, 2009B091300018, 2010B090300027]
  4. Chinese Academy of Sciences [2011A090100008, 2009B091300018, 2010B090300027]

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Oyster peptides were produced from Crassostrea hongkongensis and used as a new protein source for the preparation of an oyster peptide-based enteral nutrition formula (OPENF). Reserpineinduced malabsorption mice and cyclophosphamide-induced immunosuppression mice were used in this study. OPENF powder is light yellow green and has a protein-fat-carbohydrate ratio of 16:9:75 with good solubility in water. A pilot study investigating immune functional impacts of the OPENF on mice show that the OPENF enhanced spleen lymphocyte proliferation and the activity of natural killer (NK) cells in BALB/c mice. Furthermore, OPENF can improve intestinal absorption, increase food utilization ratio, and maintain the normal physiological function of mice. These results suggest that oyster peptides could serve as a new protein source for use in enteral nutrition formula, but more importantly, also indicate that OPENF has an immunostimulating effect in mice.

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