Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 30, Issue 9, Pages 2085-2090Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201200603
Keywords
self-assembly; cucurbituril; vesicles; supramolecular amphiphiles; drug delivery
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Funding
- National Natural Science Foundation of China [91027023, 20921003, 21004028]
- 111 Project [B06009]
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Cucurbituril (CB), a well-known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host-guest intertactions, an adamantanyl derivative guest molecule was designed and synthesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self-assemble into well-defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1-adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.
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