4.5 Article

Eco-friendly and Efficient Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Journal

CHINESE JOURNAL OF CHEMISTRY
Volume 29, Issue 8, Pages 1617-1623

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201180290

Keywords

solvent-free; synthetic methods; aldehydes; 2,3-dihydroquinazolin-4(1H)-one; anthranilamide; isatoic anhydride

Funding

  1. Sistan and Baluchestan University Research Council

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A simple and facile method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones through the direct cyclocondensation of one-pot three-component cyclocondensation of isatoic anhydride, ammonium acetate (or primary amines) and aldehydes; and anthranilamide and aldehydes using silica supported ferric chloride (SiO2-FeCl3) as catalyst under solvent-free conditions is described.

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