Synthesis and Physicochemical Properties of 3-Fluorocyclobutylamines

Designing novel building blocks is an overlooked strategy to improve compound quality

(2015) Frederick W. Goldberg et al.   DRUG DISCOVERY TODAY

C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

(2014) Xiaohui Du et al.   ACS Medicinal Chemistry Letters

Conformationally restricted glutamic acid analogues: stereoisomers of 1-aminospiro[3.3]heptane-1,6-dicarboxylic acid

(2014) Anton V. Chernykh et al.   RSC Advances

Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State19F NMR Spectroscopy

(2013) Anton N. Tkachenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselectively fluorinatedN-heterocycles: a brief survey

(2013) Xiang-Guo Hu et al.   Beilstein Journal of Organic Chemistry

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

On the polarity of partially fluorinated methyl groups

(2013) Quentin A. Huchet et al.   JOURNAL OF FLUORINE CHEMISTRY

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

(2013) Yujun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A convenient approach towards the 1-aminomethyl-1-fluorocycloalkane scaffold

(2013) Matthias Moens et al.   TETRAHEDRON LETTERS

Confining the χ space of basic natural amino acids: cyclobutane-derived χ1,χ2-constrained analogues of arginine, lysine and ornithine

(2012) Dmytro S. Radchenko et al.   TETRAHEDRON

Hydrogen bonds with fluorine. Studies in solution, in gas phase and by computations, conflicting conclusions from crystallographic analyses

(2012) Hans-Jörg Schneider   Chemical Science

New and unusual scaffolds in medicinal chemistry

(2011) Charles M. Marson   CHEMICAL SOCIETY REVIEWS

Discovery of Two Clinical Histamine H3Receptor Antagonists:trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) andtrans-3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

(2011) Travis T. Wager et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring-Puckered Mimics ofGauche- andAnti-3-Fluoro- and 3-Hydroxypyrrolidines

(2011) Grant R. Krow et al.   JOURNAL OF ORGANIC CHEMISTRY

Imidazo[2,1-b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases

(2010) Steve D. Fidanze et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma

(2010) Weiping Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclobutane-Derived Diamines: Synthesis and Molecular Structure

(2010) Dmytro S. Radchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Cyclobutane Amino Acid Analogues of Furanomycin Obtained by a Formal [2 + 2] Cycloaddition Strategy Promoted by Methylaluminoxane

(2009) Alberto Avenoza et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines

(2008) Svenja Hruschka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Conformational preferences and basicities of monofluorinated cyclopropyl amines in comparison to cyclopropylamine and 2-fluoroethylamine

(2008) Isabella Hyla-Kryspin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective synthesis of cis- and trans-3-fluoro-1-phenylcyclobutyl amine

(2008) Pengcheng P. Shao et al.   TETRAHEDRON LETTERS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS