Article
Chemistry, Multidisciplinary
Shaochen Zhou, Lotta Gustavsson, Gregory Beaune, Sourov Chandra, Jukka Niskanen, Janne Ruokolainen, Jaakko V. I. Timonen, Olli Ikkala, Bo Peng, Robin H. A. Ras
Summary: This work presents a general and efficient method to synthesize pH-responsive near-infrared (NIR) emitting gold nanoclusters by introducing aliphatic tertiary amine (TA) groups as ligands. The pH-responsive NIR emission is achieved through the protonation and deprotonation of TA groups, which induce electronic structure changes. The pH-responsive gold nanoclusters can serve as specific and sensitive probes for lysosomes in cells, offering non-invasive emissions without interference from intracellular autofluorescence.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biotechnology & Applied Microbiology
Pengcheng Xu, Ru Wang, Wenqian Yang, Yanyan Liu, Dongsheng He, Zixuan Ye, Daquan Chen, Yuan Ding, Jiasheng Tu, Yan Shen
Summary: The study successfully designed a nanocarrier (DM1-mPEG/HER-PGNSs) with excellent tumor-targeting capability, multimodal imaging ability, and anti-tumor therapeutic efficacy in vivo. The nanocarrier, prepared by incorporating DM1, mPEG, and HER into PGNSs, exhibited outstanding drug release properties and photothermal conversion ability. Selective uptake by cancer cells in vitro and accumulation at tumor sites in vivo were observed, highlighting the potential of these unique gold nanocarriers for precision nanomedicine in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Tsuyoshi A. Kohlgruber, Ganna A. Senchyk, Virginia G. Rodriguez, Stephanie A. Mackley, Fabrice Dal Bo, Sergey M. Aksenov, Jennifer E. S. Szymanowski, Ginger E. Sigmon, Allen G. Oliver, Peter C. Burns
Summary: Two uranyl vanadate heteropolyoxometalates (h-POMs) were synthesized by ionothermal methods using an ionic liquid, resulting in complex structures with different core and shell compositions. The structures can be categorized into two types: {U8V6} and {U6V3}, with some core structures containing actinyl oxide clusters while others are linked into extended structures by phosphate oxyanions.
INORGANIC CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Asmita Banstola, Kishwor Poudel, Fakhrossadat Emami, Sae Kwang Ku, Jee-Heon Jeong, Jong Oh Kim, Simmyung Yook
Summary: This study developed anti-PD-L1 conjugated and doxorubicin loaded hollow gold nanoshell for targeted and localized chemo-photothermal therapy of locally advanced melanoma. The treatment showed significant improvement in survival rate and anticancer effect, making it a promising strategy for melanoma therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Shu-Jyuan Yang, Hsiao-Ting Huang, Chung-Huan Huang, Jui-An Pai, Chung-Hao Wang, Ming-Jium Shieh
Summary: HSP@Au NPs were developed for combined chemo-photothermal therapy to treat colorectal cancer, showing significant anticancer activity in vitro and in vivo without adverse effects.
Article
Chemistry, Physical
Jingyang Sun, Yoona Song, Jae-Sang Ryu
Summary: The gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds exhibits good yields, high regioselectivity, and broad substrate scope. It can also be applied to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.
Article
Chemistry, Organic
Baofu Zhu, Jiaming He, Kai Zou, Anquan Li, Chen Zhang, Jiaji Zhao, Hua Cao
Summary: This study established a three-component reaction catalyzed by base, involving ynals, isocyanates, amines, and alcohols. The strategy enables a wide range of substrates and provides a simple process for the preparation of diverse pyridine derivatives with good yields and high regioselectivities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Xiaoqiong Huang, Lei Xu, Xiaoran Yu, Yiming Li, Ziqing Huang, Ruogu Xu, Wenyi Zeng, Zhengchuan Zhang, Weichang Li, Feilong Deng
Summary: Treatment for chronic diabetic wounds remains a clinical challenge. A multifunctional hydrogel with two-stage sequential release upon NIR stimulation, antibacterial activity and pro-angiogenic efficacy has been developed. This hydrogel consists of covalently crosslinked bilayer structure with peptide-functionalized gold nanorods embedded in each layer.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Santosh Kumar Bikkarolla, Sara E. McNamee, Paul Vance, James McLaughlin
Summary: Au nanoparticles have long been used as signal reporters in lateral flow immunoassays (LFAs), but their low brightness hampers the sensitivity of detection. In this study, 150 nm gold nanoshells (AuNSs) were used as an alternative with 35 times more brightness compared to AuNPs. The developed AuNS-based LFA achieved a 26-fold improvement in detection sensitivity for thyroid-stimulating hormone (TSH). The device has potential for early screening and diagnosis of thyroid hormone-related diseases.
Article
Nanoscience & Nanotechnology
Marina Simon, Jesper Tranekjaer Jorgensen, Kamilla Norregaard, Jonas Rosager Henriksen, Gael Clergeaud, Thomas L. Andresen, Anders Elias Hansen, Andreas Kjaer
Summary: Traditional cancer treatments are often insufficient to achieve complete responses, so combination therapies are commonly used. Nanoparticle-based photothermal therapy (PTT) is a promising add-on treatment that uses localized hyperthermia to kill cancer cells. In this study, we evaluated the combination of gold nanoshell-based PTT and liposomal doxorubicin for colorectal cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Nanda Rohra, Ganesh Gaikwad, Prajakta Dandekar, Ratnesh Jain
Summary: In this study, a metal-organic framework (MOF) for insulin delivery based on the stimulus response of glucose was synthesized using a microfluidic system. The MOF, which encapsulated insulin and gold nanoparticles, responded to glucose by releasing insulin.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Si-Dong Zhang, Mu-Yao Qi, Sijie Guo, Yong-Gang Sun, Ting-Ting Wu, Hong-Shen Zhang, Si-Qi Lu, Fanqi Meng, Qinghua Zhang, Lin Gu, Zhiwei Zhao, Zhangquan Peng, Hongchang Jin, Hengxing Ji, Ying-Rui Lu, Ting-Shan Chan, Ran Duan, An-Min Cao
Summary: A multifunctional shell of MgO/Li3PO4 was successfully fabricated on the surface of 4.6 V LiCoO2 cathode, which effectively stabilized the cathode by inhibiting interfacial side reactions and structure degradation. The shell not only prevented capacity decay but also improved Li+ transfer rate, leading to a high reversible capacity and outstanding rate capability.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Physical
Xuejiao Li, Bo Li, Rui Li, Yunzhong Yao, Na Fan, Rui Qi, Zilong Xu, Weiwei Cui, Huanyan Xu, Lianwei Shan, Xin Liu, Limin Dong
Summary: Photothermal therapy (PTT) is a promising alternative to traditional cancer therapy, and using photothermal agents (PTAs) in the second near-infrared window shows great potential for enhanced PTT treatment of deep tumors. In this study, paramagnetic ZnFe2O4 nanospheres with a defective structure were synthesized, and their characteristics and photothermal performance were discussed under NIR-I/II laser irradiation. The samples exhibited good magnetic properties and high photothermal conversion efficiency, surpassing previous nano-PTAs in the NIR-I/II region. This work provides a simple method to obtain clinical paramagnetic PTAs for NIR-II photothermal therapy.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Materials Science, Ceramics
Tenglong Guo, Yuanbing Li, Shujing Li, Zhe Qiao, Jingfei Liu, Xiaoxiao Li
Summary: This study successfully synthesized almost fully monoclinic high-temperature composite ceramic matrix Celsian through a simple one-step solid-state reaction process at lower temperature and shorter time by choosing mullite as the main raw material, effectively avoiding the appearance of BaAl2O4 in Hexacelsian. It achieved a significant improvement compared to the higher temperatures and longer holding times required for the synthesis of Celsian from other raw materials, according to previous literature.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Chemistry, Physical
Ngoc Minh Tran, Suncheol Kim, Hyojong Yoo
Summary: The controlled synthesis of gold nanodot assembly within cobalt chalcogenide nanoshell results in dots-in-shell Au/CoxSy nanohybrids with enhanced performance for the oxygen evolution reaction. This is achieved through the synergistic effect of well-dispersed Au nanodots and thin CoxSy nanoshell, leading to low overpotential values and a small Tafel slope.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Dan Ni, Longlong Song, Yun Zhao, Shunying Liu
Summary: A Rh(II)/boron reagent co-catalyzed transformation was developed for the efficient synthesis of multi-substituted conjugated dienones under mild conditions. By trapping allene carbocations with oxonium ylides, two C=C double bonds, one C-C single bond, and one C-O single bond were constructed in yields up to 85%. Furthermore, a diversity-oriented strategy was established for the synthesis of alkyne ether and dihydrofuran derivatives in a substrate-dependent manner.
CHEMICAL COMMUNICATIONS
(2022)
Article
Engineering, Electrical & Electronic
Junjie Li, Yu Liang, Yunhui Mei, Xinling Tang, Guo-Quan Lu
Summary: This article presents a high-voltage packaging method for >15-kV SiC power devices, which includes an optimized stacked direct bond copper (DBC) substrate and a field-dependent conductivity (FDC) encapsulation using SiC as the filler. The proposed FDC encapsulation is proven to be a promising alternative to commercial silicone, with significant improvements in partial discharge initial voltage (PDIV) and maximum voltage rating.
IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION
(2022)
Article
Automation & Control Systems
Shengchang Lu, Tianyu Zhao, Zichen Zhang, Khai D. T. Ngo, Rolando Burgos, Guo-Quan Lu
Summary: A packaging technique for gallium-nitride power transistors was developed to address the challenges of low parasitic inductance and high heat dissipation.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Meiyu Wang, Yunhui Mei, Weibo Hu, Xin Li, Guo-Quan Lu
Summary: This research focuses on the application of low-temperature silver sintering technology in packaging SiC and Si devices. The effects of different substrate metallizations on the mechanical, electrical, and thermal characteristics are evaluated. The purpose of this research is to provide practical considerations for developing Si and SiC sintered-Ag die-attaching profiles.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2022)
Article
Engineering, Electrical & Electronic
Chao Ding, Jared Cohen, Khai D. T. Ngo, Guo-Quan Lu
Summary: The development of magnetic pastes is a complex and time-consuming task, but a computer-aided approach can simplify the process and provide simulation results that match well with experimental data.
IEEE TRANSACTIONS ON MAGNETICS
(2022)
Article
Engineering, Electrical & Electronic
Boyan Wang, Ming Xiao, Zichen Zhang, Yifan Wang, Yuan Qin, Qihao Song, Guo-Quan Lu, Khai Ngo, Yuhao Zhang
Summary: Size optimization of Achip is crucial for accurate cost analysis and design of multichip modules, especially for high-cost WBG and UWBG power devices. This study presents a new electrothermal approach to optimize Achip for a given set of specifications, considering breakdown voltage, conduction current, and switching frequency. The approach takes into account conduction and switching losses, as well as heat dissipation in the chip and package. It provides guidelines for power module design and offers more accurate cost analysis.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Review
Engineering, Electrical & Electronic
Panpan Lu, Longnv Li, Guo-Quan Lu, Zhibin Shuai, Xinhua Guo, Yun-Hui Mei
Summary: Power module packaging technologies are evolving to meet the compact high-power-density requirements. This article summarizes the thermal and electrical advantages of double-sided cooling power modules compared to wire-bonding. It also provides detailed introductions of typical double-sided cooling power modules developed by institutes or companies. The challenges and future trends of double-sided cooling power modules are highlighted.
IEEE TRANSACTIONS ON DEVICE AND MATERIALS RELIABILITY
(2023)
Article
Engineering, Electrical & Electronic
Siqi Liu, Yun-Hui Mei, Jing Li, Xin Li, Guo-Quan Lu
Summary: The use of a composite buffer layer can effectively reduce thermomechanical stress caused by the mismatch of coefficients of thermal expansion (CTE) in double-sided bidirectional modules (BMs), thereby improving the reliability of the module.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Article
Chemistry, Physical
Longlong Song, Lulu Xiong, Dan Ni, Weixiong Chen, Jian Ji, Jian Xue, Xuwen Chen, Xiang Wu, Xiao He, Shunying Liu
Summary: Here, we report a [Pd-(eta(3)-C3H5)-Cl](2)/Sc-(OTf)(3)-catalyzed catalytic process accelerated by Bronsted acids with a beta-selective aza-Michael addition to yield a gamma-quaternary carbon. The triple co-catalytic system provides a strategy for the activation of vinyl-quinolines with a linear selectivity containing gamma-quaternary carbon, and the developed method shows a broad substrate scope, providing a general and rapid strategy for the quinoline-based diverse library construction.
Article
Engineering, Electrical & Electronic
Chao Ding, Shengchang Lu, Zichen Zhang, Kun Zhang, Tam Nguyen, Khai D. T. Ngo, Rolando Burgos, Guo-Quan Lu
Summary: Low-profile double-side cooled power modules are being used in electric-drive inverters to achieve higher power density and efficiency. The use of porous sintered-silver (Ag) interposers in these modules has been proposed to reduce thermomechanical stresses and improve heat extraction. A revised half-bridge module layout was also proposed to further reduce power-loop parasitic inductance and improve power handling capability. The modules were fabricated using high-temperature packaging materials and showed excellent power handling capability, validated through thermal and electrical testing.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Article
Chemistry, Organic
Cong Guan, Jiabin Yin, Jian Ji, Jinhua Liu, Xiang Wu, Tong Zhu, Shunying Liu
Summary: A regioselective electrochemical C-H amination method using easily accessible ethers has been developed to synthesize N (2)-substituted 1,2,3-triazole. Multiple substituents, including heterocycles, were well-tolerated, and 24 examples were obtained in moderate to good yields. Control experiments and DFT calculations revealed that the electrochemical synthesis occurs through a N-tosyl 1,2,3-triazole radical cation process, promoted by single-electron transfer from the lone pair electrons of the aromatic N-heterocycle, and the desulfonation is responsible for the high N (2)-regioselectivity.
Article
Chemistry, Multidisciplinary
Jian Ji, Zongjing Hu, Cong Guan, Jinhua Liu, Yaqi Deng, Xuwen Chen, Shunying Liu
Summary: An efficient method for the 1,2-carbotriazolization of alkenes with N-sulfonyl-1,2,3-triazoles and aldehydes has been developed using a copper-catalyzed radical relay process. This strategy enables the production of beta-triazolized ketones with high regio- and chemoselectivity, and has a wide substrate scope. The resulting beta-triazolized ketone scaffold shows promising inhibitory activity on osteosarcoma cell lines, making it a potential pharmacophore for drug discovery.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Physical
Longlong Song, Lulu Xiong, Dan Ni, Weixiong Chen, Jian Ji, Jian Xue, Xuwen Chen, Xiang Wu, Xiao He, Shunying Liu
Summary: This study reports a [Pd(eta 3-C3H5)Cl]2/Sc(OTf)3 catalytic system accelerated by Brønsted acids for the selective aza-Michael addition of vinyl-substituted quinolines, diazos, and anilines/alcohols. The activation of the corresponding Lewis acid by the generation of anhydride analogues from Brønsted acid and the counter anion (OTf-) promotes nearly quantitative transformation. The triple co-catalytic system provides a strategy for the activation of vinylquinolines with a linear selectivity containing gamma-quaternary carbon.
Article
Chemistry, Organic
Ji Jian, Liu Jinhua, Guan Cong, Chen Xuwen, Zhao Yun, Liu Shunying
Summary: The green and efficient synthesis of N-2-substituted 1,2,3-triazoles was achieved by coupling cheap and easily available alcohols with N-sulfonyl-1,2,3-triazole using in-situ generated sulfonic acid as a catalyst. The reaction exhibited high regioselectivity and good yields without the need for additional catalysts or additives. Mechanistic studies suggested that the reaction was promoted by methanesulfonic acid (MsOH) generated from the hydrolysis of N-sulfonyl-1,2,3-triazoles, and high regioselectivity was achieved through a thermally stable intermediate.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Zhengli Luo, Xuwen Chen, Jian Xue, Yaqi Deng, Suzhen Dong, Shunying Liu
Summary: A method has been developed for the rapid and efficient synthesis of benzosultams containing continuous quaternary carbons in a one-pot fashion, with moderate to excellent yields at room temperature. The resulting products exhibit good anticancer activity in osteosarcoma cells.
ORGANIC CHEMISTRY FRONTIERS
(2022)
