Article
Multidisciplinary Sciences
Ziqing Yang, Shaomin Zou, Yijing Zhang, Jieping Zhang, Peng Zhang, Lishi Xiao, Yunling Xie, Manqi Meng, Junyan Feng, Liang Kang, Mong-Hong Lee, Lekun Fang
Summary: Elevated expression of ACTL6A in gastric cancer promotes glutathione synthesis by regulating GCLC expression to suppress ferroptosis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Tao Pan, Zhenjia Yu, Zhijian Jin, Xiongyan Wu, Airong Wu, Junyi Hou, Xinyu Chang, Zhiyuan Fan, Jianfang Li, Beiqin Yu, Fangyuan Li, Chao Yan, Zhongyin Yang, Zhenggang Zhu, Bingya Liu, Liping Su
Summary: The study revealed that lnc-CTSLP4 is significantly downregulated in gastric cancer tumor tissues, and by interacting with proteins and recruiting E3 ubiquitin ligase ZFP91, it inhibits the metastatic potential of GC cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Jingdong Liu, Haojie Li, Peng Zhou, Tianyi Cai, Zhaoqing Tang, Yan Wang, Yuehong Cui, Yihong Sun, Xuefei Wang
Summary: The study demonstrates that the use of immunohistochemistry (IHC) can enhance the detection of lymphovascular invasion (LVI) in gastric cancer patients, providing more accurate prediction of pathological stage and lymph node metastasis.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Wen-Hsuan Tsai, Tze-Chien Chen, Shuen-Han Dai, Yi-Hong Zeng
Summary: Adrenocortical carcinoma (ACC) is a rare malignancy with endocrinological issues and may present as neuroendocrine carcinoma. Pathological testing and immunohistochemical staining are crucial for diagnosis, and complete surveys are needed to determine whether the ectopic ACC is functional.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Sunayana Misra, Priyadarshna Mudgal, Arvind Ahuja
Summary: Gastrointestinal metastasis from breast carcinoma is a rare occurrence that can present with symptoms of gastric outlet obstruction. It mimics a variety of benign and malignant causes of gastric outlet obstruction, sometimes leading to misdiagnosis as primary malignancy. A high index of suspicion and appropriate histologic and immunohistochemistry examinations are crucial for accurate diagnosis.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Oncology
Lei Jiang, Yan Chen, Guangtao Min, Jun Wang, Wei Chen, Hongpeng Wang, Xiangwen Wang, Nan Yao
Summary: BAG4 has been found to be overexpressed in gastric cancer tissues compared to normal tissues, and its elevated expression is associated with advanced tumor characteristics and poor patient outcomes. Mechanistically, BAG4 promotes invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-kappa B/ZEB1 axis to induce epithelial-mesenchymal transition.
Article
Medicine, General & Internal
Sirin Kucuk
Summary: The study aimed to investigate the importance and prognostic value of tumour budding (TB) in Gastric Carcinoma (GC). Pathologic grading of tumours was performed according to the criteria specified by the American Joint Committee on Cancer (AJCC). The study found a significant relationship between tumour budding and characteristics such as pathologic stage, lymph node involvement, and grade, suggesting that tumour budding could be used in the standardisation of diagnosis and prognostic factors in GC.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Oncology
Xing Xu, Guoliang Zheng, Tao Zhang, Yan Zhao, Zhichao Zheng
Summary: The study found that the micrometastatic rate of LN14v lymph nodes was 3.3%, while the metastatic rate was 15.8%, leading to a poorer prognosis. In patients with stage III gastric cancer, lymphadenectomy of LN14v may improve survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yiyang Hu, Chunli Gong, Zhibin Li, Jiao Liu, Yang Chen, Yu Huang, Qiang Luo, Sumin Wang, Yu Hou, Shiming Yang, Yufeng Xiao
Summary: This study established an ALKBH5-PKMYT1-IGF2BP3 regulation system in metastasis, providing a new therapeutic target for gastric cancer metastasis.
Article
Multidisciplinary Sciences
Zirui Jia, Jiacheng Gao, Yuhang Wang, Tingting Zhou, Xiangwen Zhang, Guo Zu
Summary: Through meta-analysis and bioinformatics analysis, the study investigated the relationship between LOX expression and methylation level with clinicopathological parameters and prognosis in GC patients. Results showed that LOX expression was related to lymph node metastasis, tumor distant metastasis, and poor prognosis, while low methylation levels were associated with advanced tumor stage and poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Anatomy & Morphology
Xiangwen Zhang, Jiaming Xue, Huiliang Yang, Tingting Zhou, Guo Zu
Summary: TNFAIP6 plays an important role in the prognosis of gastric cancer patients, with higher expression levels associated with tumor invasion depth, lymph node metastasis, TNM stage, and poorer overall survival. Knockdown of TNFAIP6 inhibited proliferation, invasion, and metastasis of gastric cancer cells in vitro.
Article
Biochemistry & Molecular Biology
Rita Moreno, Sourav Banerjee, Angus W. Jackson, Jean Quinn, Gregg Baillie, Jack E. Dixon, Albena T. Dinkova-Kostova, Joanne Edwards, Laureano de la Vega
Summary: In triple-negative breast cancer (TNBC) cells, DYRK2 phosphorylates HSF1 to promote its nuclear stability and transcriptional activity, with DYRK2 depletion reducing HSF1 activity. Moreover, DYRK2 levels positively correlate with active HSF1 in TNBC tumors and associate with poor prognosis, suggesting DYRK2 may be promoting TNBC.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Fengxiang Zhang, Huaxian Chen, Dandong Luo, Zhizhong Xiong, Xianzhe Li, Shi Yin, Longyang Jin, Shi Chen, Junsheng Peng, Lei Lian
Summary: Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with poorer prognosis in gastric cancer (GC). This study aimed to investigate their prognostic value in curative resected GC patients. The incidence of LVI/PNI was significantly higher in GC patients compared to colorectal cancer patients (50.54% vs. 21.91%, p < 0.001). LVI/PNI was closely associated with disease progression and served as an independent risk factor for lymph node metastasis and overall survival in GC.
Article
Pathology
Christina M. Gutierrez, Bradley C. Carthon, Shreyas Joshi, Adeboye O. Osunkoya
Summary: Primary urothelial carcinoma of the ureter is a relatively rare type of urinary tract tumor, often found in association with other urinary tract tumors. Our understanding of this type of cancer is limited due to the lack of comprehensive studies, highlighting the need for further research to explore its clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Pathology
Hideaki Mita, Hiroto Katoh, Daisuke Komura, Miwako Kakiuchi, Hiroyuki Abe, Hirofumi Rokutan, Koichi Yagi, Sachiyo Nomura, Tetsuo Ushiku, Yasuyuki Seto, Shumpei Ishikawa
Summary: In this study, immunohistochemical analysis of 342 gastric cancer cases revealed that approximately half of the samples showed aberrant expression of CDH11 in gastric cancer cells. The aberrant expression of CDH11 was statistically associated with bone metastasis, as well as liver and distant lymph node metastasis. Therefore, aberrant CDH11 expression in gastric cancer cells can serve as a predictive biomarker for distant metastasis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)