The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities

(2020) Jacopo Boni et al.   Cancers

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

(2019) Sourav Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

(2018) Katie L. Uhl et al.   Cancer Cell International

Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer

(2018) Yoshimi Imawari et al.   CANCER SCIENCE

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

(2018) Sourav Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

(2018) Prasun Chakraborty et al.   Nature Communications

Regulation of the mammalian heat shock factor 1

(2017) Sharadha Dayalan Naidu et al.   FEBS Journal

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

(2016) Sharadha Dayalan Naidu et al.   MOLECULAR AND CELLULAR BIOLOGY

Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer

(2016) Haiyan Yan et al.   PLoS One

MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

(2015) Zijian Tang et al.   CELL

Causes and consequences of protein folding stress in aneuploid cells

(2015) Neysan Donnelly et al.   CELL CYCLE

Therapies for triple negative breast cancer

(2015) Eleni Andreopoulou et al.   EXPERT OPINION ON PHARMACOTHERAPY

When Cancer Fights Back: Multiple Myeloma, Proteasome Inhibition, and the Heat-Shock Response

(2015) S. P. Shah et al.   MOLECULAR CANCER RESEARCH

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

(2015) Xing Guo et al.   NATURE CELL BIOLOGY

FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification

(2015) Nikos Kourtis et al.   NATURE CELL BIOLOGY

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways

(2015) Xinyan Wu et al.   Oncotarget

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors

(2015) Katharina Rüben et al.   PLoS One

High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors

(2014) H Engerud et al.   BRITISH JOURNAL OF CANCER

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells

(2014) N. Donnelly et al.   EMBO JOURNAL

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288

(2013) Anne L. Ashford et al.   BIOCHEMICAL JOURNAL

Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

(2013) Shruti Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

(2012) Laureano de la Vega et al.   MOLECULAR CELL

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

(2012) Shiuh-Dih Chou et al.   PLoS One

Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways

(2012) Moisés Pérez et al.   Journal of Molecular Cell Biology

Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo

(2011) Feng Fang et al.   CANCER

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

(2011) S. Santagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis

(2010) L Meng et al.   ONCOGENE

Protein Kinase A Binds and Activates Heat Shock Factor 1

(2010) Ayesha Murshid et al.   PLoS One

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

(2009) Nora Göckler et al.   FEBS Journal

Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4

(2008) Peter Lee et al.   MOLECULAR MICROBIOLOGY

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE