Article
Chemistry, Organic
En Cheng, Jun Chi, Yi-Xiao Li, Wei-Jin Zhang, Na Huang, Zhi-Min Wang, Li-Ping Dai, Er-Ping Xu
Summary: Phytochemical investigation of Isodon henryi led to the discovery of two new diterpenoids, isohenolides AB (1-2), one new natural diterpenoid (3), and thirteen known ones (4-16). These compounds exhibited diverse structures and showed anti-inflammatory activities.
TETRAHEDRON LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Qian Tan, Kun Hu, Xiao-Nian Li, Xing-Zhi Yang, Han-Dong Sun, Pema-Tenzin Puno
Summary: Twenty new ent-kaurane diterpenoids, named as wardiisins A-T, were isolated from the aerial part of Isodon wardii, along with two previously undescribed artefactual compounds and twelve known analogues. Most of them exhibited unusual C-12 oxygenation. Compounds 4, 7, 8, 19, 20, 21 showed significant cytotoxicity against various cancer cell lines, with IC50 values ranging from 0.3 to 5.2 μM. Additionally, compound 7 induced G2/M cell cycle arrest and promoted apoptosis in SW480 cell lines.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Jun Wei, Bingqiang Zhu, Yanpo Si, Tao Guo, Jihong Kang, Liping Dai
Summary: One new and 11 reported ent-kaurane diterpenoids were isolated from the ethanol extract of Rabdosia rubescens. The structures of these compounds were determined and their cytotoxic activity against lung cancer cell lines was evaluated. Compounds 2-6 showed significant cytotoxic activity with potential inhibitory effects on lung cancer cell proliferation.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Applied
Xue Jiang, Ling-Xia Zhang, Qing-Mei Feng, Hong Wu, Ya-Lin Liu, De-Qin Wang, Li-Ping Dai, Zhi-Min Wang
Summary: A new ent-kaurane diterpenoid was isolated from Isodon henryi, along with ten other diterpenoids, including six 7,20-epoxy and three enmenol-type compounds. The cytotoxicities of these compounds were evaluated in various cancer cell lines, revealing potential anti-cancer properties.
NATURAL PRODUCT RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Traore S. Ibrahim, Purevdulam Khongorzul, Moses Muyaba, Raphael N. Alolga
Summary: This article mainly introduces the Annonaceae family, which is credited with numerous pharmacological functions, including the ent-kaurane diterpenoids. The ent-kauranes are a group of 20-Carbon, tetracyclic diterpenoids that are widely distributed in the Annonaceae family as well as other plant families. This mini-review discusses the various biological activities of the ent-kaurane diterpenoids isolated from the Annonaceae family and highlights the existing research gaps for further scientific scrutiny.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Applied
GuiLin Hu, XingRong Peng, Ding Dong, Yin Nian, Ya Gao, XiaoYuan Wang, DeFu Hong, MingHua Qiu
Summary: In this study, ten new and five known ent-kaurane diterpene derivatives were identified from roasted coffee beans. Several compounds showed moderate inhibitory effects on alpha-glucosidase, with those containing a double bond between C-15 and C-16 exhibiting stronger activity. Molecular docking experiments were also conducted to discuss the mechanism of action.
Article
Biochemistry & Molecular Biology
Yong Sun, Yanan Qiao, Yue Liu, Jinchuan Zhou, Xue Wang, Hongbo Zheng, Zejun Xu, Jiaozhen Zhang, Yi Zhou, Lilin Qian, Chunyang Zhang, Hongxiang Lou
Summary: Ent-kaurane diterpenoids can disrupt redox homeostasis to promote cancer cell death, with compound 23 showing strong inhibitory activity against various cancer cell lines by inducing apoptosis and ferroptosis through increased cellular ROS levels. Compound 23 also sensitizes cisplatin-resistant cancer cells by dual inhibition of Prdx I/II and GSH, suggesting its potential application in cancer chemotherapy.
Article
Chemistry, Multidisciplinary
Zhi-li Wu, Jia-yu Li, Peng-li Huang, Ze-shi Sun, Hui-liang Li, Wei-dong Zhang
Summary: Eleven new diterpenoid acids were isolated from Nouelia insignis Franch, and their chemical structures were determined using various methods. The compounds were tested for their anti-inflammatory activity, and some of them showed significant inhibition of nitric oxide production and regulation of protein expression levels related to inflammation.
Article
Chemistry, Medicinal
Ying Xin, Jia Xu, Jun-Jiang Lv, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang
Summary: Six diterpenoids, including three newly discovered compounds, were isolated from Phyllanthus acidus. These compounds exhibited cytotoxic and anti-inflammatory activities.
Article
Plant Sciences
Thais A. da Costa-Silva, Matheus L. Silva, Guilherme M. Antar, Andre G. Tempone, Joao Henrique G. Lago
Summary: In this study, three ent-kaurane diterpenes isolated from Baccharis sphenophylla aerial parts showed potent activity against Trypanosoma cruzi parasites. Compound 1 induced depolarization of the plasma membrane electric potential, while compound 3 caused a transient hyperpolarization of the mitochondrial membrane potential, both contributing to an osmotic imbalance in the cell. These compounds could be interesting prototypes for the discovery of new hits against T. cruzi.
Article
Biochemistry & Molecular Biology
Mengyang Hou, Duo Cao, Mao Wang, Xuecheng Zhao
Summary: Phytochemical research on Pteris dactylina Hook. led to the discovery of fourteen compounds, including eight pterosin sesquiterpenoids and six ent-kaurane diterpenoids. These compounds were identified based on various data, and all of them were isolated for the first time from P. dactylina. Additionally, two compounds were also newly discovered from the genus Pteris and the family Pteridaceae. The chemotaxonomic significance of these isolates was discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Plant Sciences
Hui Ren, Shao-Bo Liu, Tao Lou, Fen-Yu Fu, Qiao-Lin Xu, Shan-Xuan Zhang, Jian-Wen Tan
Summary: Two new ent-kaurane diterpenoids were isolated and identified from the leaves of Sphagneticola trilobata, along with eight known compounds. These compounds were tested for their in vitro α-glucosidase inhibitory activity and tyrosinase inhibitory potential. Compound 2, 3, and 6 showed strong α-glucosidase inhibitory activity, and compound 2 and 6 exhibited moderate tyrosinase inhibitory activity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Seiji Tanaka, Michiho Ito
Summary: The terrestrial plants Isodon japonicas and Isodon trichocarpus, native to Japan, have been traditionally used as bitter stomachic. Major constituents of these plants are ent-kaurane diterpenoids, however, their variability limits their pharmaceutical use. Factors affecting the chemical composition of Isodon herb, including process of milling and ratio of leaves to stems, were identified in the study.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Qiong Zhou, Si-Qi Li, Cai-Ceng Liao, Wei-Feng Dai, Kai-Rui Rao, Xiu-Rong Ma, Rong-Tao Li, Xuan-Qin Chen
Summary: Several novel diterpenoids were isolated from Tripterygium wilfordii, including compounds with rare structures that exhibited significant anti-inflammatory activity. These findings provide valuable insights for the development of novel anti-inflammatory drugs.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Ge Wang, Tong Chen, Peng-Ju Guo, Shou Peng, Wen-Qiong Wang, Li-Jiang Xuan
Summary: Three new ent-kauranoids with an adenine group and six known ent-kauranoids were isolated from Isodon japonica var. glaucocalyx. The structures of the compounds were determined using NMR and MS measurements, and the absolute configuration of one compound was determined using experimental and calculated electronic circular dichroism spectra. Compounds 6 and 8 exhibited significant inhibitory activities on PCSK9 expression at 20 μM.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)