Article
Medicine, General & Internal
Haixu Yu, Wei Rong, Jie Yang, Jie Lu, Ke Ma, Zhuohui Liu, Hui Yuan, Lei Xu, Yulin Li, Zhi-Cheng Jing, Jie Du
Summary: This study found that reduced plasma TRAIL levels predict short-term adverse events in normotensive patients with acute PE. The combination of TRAIL and hs-cTnI as a biomarker-based risk stratification strategy has a similar risk classification effect in normotensive patients with acute PE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Qiang Zhou, Jianxia Yuan, Yi Liu, Yayun Wu
Summary: Cisatracurium besilate inhibits gastric cancer cell proliferation, promotes apoptosis, increases the expression of p53 and PUMA, and enhances TRAIL-induced apoptosis. However, pifithrin-alpha can reverse the synergistic effects of cisatracurium besilate and TRAIL on AGS cell activities.
Review
Physiology
Laurel A. Grisanti
Summary: Cardiovascular disease is a leading cause of death globally. Cardiomyocyte death, which occurs in heart damage and stress, contributes to cardiac dysfunction and further damages the heart. Apoptosis, a regulated form of cell death, can occur through intrinsic or extrinsic pathways. The poorly characterized TNF-related ligand TRAIL and its receptors have been found to play a role in cardiac pathology. This article aims to provide an overview of the current understanding of TRAIL and its receptors in normal and pathological conditions in the heart.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Atsushi Watanabe, Kunio Miyake, Koshi Akahane, Kumiko Goi, Keiko Kagami, Hideo Yagita, Takeshi Inukai
Summary: Immunotherapies specific for BCP-ALL, such as anti-CD19 CAR T-cells and blinatumomab, have significantly improved outcomes in refractory cases. The methylation status of DR4 and DR5 genes is associated with gene expression levels, cell-surface expression, and TRAIL-sensitivities, suggesting potential clinical relevance in predicting immunotherapy efficacy. Evaluating methylation status of DR4 and DR5 genes may be informative in certain cases with unfavorable karyotypes.
Article
Cell Biology
Tayyab Shahzad, Cho-Ming Chao, Stefan Hadzic, Judith Behnke, Luisa Biebach, Eva Boettcher-Friebertshaeuser, Jochen Wilhelm, Anne Hilgendorff, Klaus-Peter Zimmer, Rory E. Morty, Saverio Bellusci, Harald Ehrhardt
Summary: Hyperoxia-induced inflammation and tissue damage are crucial steps leading to BPD. TRAIL plays a protective role in lung development, and its depletion leads to structural damage.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Najib Ben Khaled, Katharina Hammer, Liangtao Ye, Ahmed Alnatsha, Sebastian A. Widholz, Ignazio Piseddu, Simon Sirtl, Julia Schneider, Stefan Munker, Ujjwal Mukund Mahajan, Juan Jose Montero, Joscha Griger, Julia Mayerle, Florian P. Reiter, Enrico N. De Toni
Summary: Research has identified frequent changes in BRCA genes in pancreatic cancer patients, especially in BRCA2. Pancreatic cancers with alterations in BRCA genes are sensitive to treatment with PARP inhibitors. This study shows that the combination of olaparib and TRAIL can be more effective than olaparib alone in killing pancreatic cancer cells. Furthermore, the combination of olaparib and TRAIL also kills cancer cells without BRCA2 mutations. These findings suggest a potential new combination therapy for pancreatic cancer independent of BRCA2 mutations.
Article
Medicine, Research & Experimental
Xin Xiao, Juan Xu, Xiaoan Sheng, Chao Wang, Juanjuan Dong, Xianfeng Shi
Summary: Tobacco nicotine use is a known risk factor for lung cancer, but its role in inducing drug resistance is unclear. This study found that nicotine upregulated the expression of SNHG5 and decreased caspase-3 levels, leading to TRAIL resistance in smokers with lung cancer. SNHG5 was found to interact with X-linked inhibitor of apoptosis protein, promoting TRAIL resistance. These findings demonstrate that nicotine promotes TRAIL resistance through the SNHG5/X-linked inhibitor of apoptosis protein pathway in lung cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Plant Sciences
Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Fernanda Tomiotto-Pellissier, Virginia Marcia Contato, Taylon Felipe Silva, Ricardo Luis Nascimento de Matos, Mariana Barbosa Detoni, Ana Carolina Jacob Rodrigues, Amanda Cristina Carloto, Danielle Bidoia Lazarin, Nilton Syogo Arakawa, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Pryscilla Fanini Wowk, Wander Rogerio Pavanelli
Summary: SOL demonstrates in vitro leishmanicidal effects against promastigotes through an apoptosis-like mechanism, while also reducing TNF-alpha and increasing IL-12p70, reactive oxygen species (ROS), and nitric oxide (NO) levels against amastigotes.
Review
Oncology
Olivia A. Diaz Arguello, Hidde J. Haisma
Summary: Cancer, a complex disease marked by evasion of apoptosis, can potentially be treated by inducing apoptosis in cancerous cells. Among the tumor necrosis factor (TNF) protein family, certain ligands possess apoptosis-inducing capabilities. Various recombinant TNF apoptosis-inducing ligands have been developed over time to improve their effectiveness in cancer treatment.
Article
Oncology
Regis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Benedicte Brounais-Le Royer, Franck Verrecchia, Francoise Redini, Romain Guiho
Summary: Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors in children. Triggering the TRAIL pro-apoptotic pathway shows promise in treating these tumors, but resistance mechanisms have limited its effectiveness. This study used human cell lines and xenograft models to investigate the differences in signaling pathways between TRAIL-sensitive and TRAIL-resistant cells, and proposed two strategies to overcome resistance.
Article
Chemistry, Multidisciplinary
Hyeonwoo Je, Gi-Hoon Nam, Gi Beom Kim, Wonjun Kim, Soo Rin Kim, In-San Kim, Eun Jung Lee
Summary: TRAIL shows promising anti-tumor activity, but faces challenges such as resistance and delivery issues. A nanocage has been developed to efficiently deliver TRAIL and a re-sensitizing drug (DOX) to overcome TRAIL-resistant tumors, demonstrating potential as an effective antitumor agent.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Kelly Xue Jing Jong, Elsa Haniffah Mejia Mohamed, Zaridatul Aini Ibrahim
Summary: This review discusses the role of TRAIL decoy receptors in modulating TRAIL-induced apoptosis in colorectal cancer. The current available in vitro, in vivo, and human studies suggest that decoy receptors might be associated with the reduced sensitivity towards TRAIL treatment, although there are discrepancies among different research groups.
Article
Cardiac & Cardiovascular Systems
Suneela Zaigham, Magnus Dencker, Magnus K. Karlsson, Ola Thorsson, Per Wollmer
Summary: This study found that elevated TRAIL levels are associated with impaired lung function in school-aged children, especially with significant associations with markers of pulmonary airflow obstruction.
RESPIRATORY MEDICINE
(2021)
Article
Oncology
Darren C. Phillips, Fritz G. Buchanan, Dong Cheng, Larry R. Solomon, Yu Xiao, John Xue, Stephen K. Tahir, Morey L. Smith, Haichao Zhang, Deborah Widomski, Vivek C. Abraham, Nan Xu, Zhihong Liu, Li Zhou, Enrico DiGiammarino, Xin Lu, Nandini Rudra-Ganguly, Bruce Trela, Susan E. Morgan-Lappe
Summary: This study highlights the activity of a hexavalent TRAIL-receptor agonistic fusion protein in preclinical models of solid tumors, distinguishing it mechanistically from other TRAIL-based therapeutics.
Review
Cardiac & Cardiovascular Systems
Na Kuang, Bingjun Shu, Fengjing Yang, Song Li, Mingxi Zhang
Summary: This meta-analysis found that decreased TRAIL levels were negatively associated with all-cause mortality, while increased TRAIL-R2 levels were positively associated with all-cause mortality, CV mortality, myocardial infarction, and new-onset heart failure.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei-Ting Huang, Mikael Larsson, Yi-Chi Lee, Dean-Mo Liu, Guang-Yuh Chiou
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2016)
Article
Multidisciplinary Sciences
Guang-Yuh Chiou, Tzu-Wei Yang, Chi-Chou Huang, Chia-Ying Tang, Jung-Yi Yen, Ming-Chang Tsai, Hsuan-Yi Chen, Nurul Fadhilah, Chun-Che Lin, Yuh-Jyh Jong
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Yi-Ping Yang, Phan Nguyen Nhi Nguyen, Tai-Chi Lin, Aliaksandr A. Yarmishyn, Wun-Syuan Chen, De-Kuang Hwang, Guang-Yuh Chiou, Tzu-Wei Lin, Chian-Shiu Chien, Ching-Yao Tsai, Shih-Hwa Chiou, Shih-Jen Chen, Chi-Hsien Peng, Chih-Chien Hsu
Article
Oncology
Huy Minh Tran, Kuo-Sheng Wu, Shian-Ying Sung, Chun Austin Changou, Tsung-Han Hsieh, Yun-Ru Liu, Yen-Lin Liu, Min-Lan Tsai, Hsin-Lun Lee, Kevin Li-Chun Hsieh, Wen-Chang Huang, Muh-Lii Liang, Hsin-Hung Chen, Yi-Yen Lee, Shih-Chieh Lin, Donald Ming-Tak Ho, Feng-Chi Chang, Meng-En Chao, Wan Chen, Shing-Shung Chu, Alice L. Yu, Yun Yen, Che-Chang Chang, Tai-Tong Wong
Article
Oncology
Kuo-Sheng Wu, Donald Ming-Tak Ho, Shiann-Tarng Jou, Alice L. Yu, Huy Minh Tran, Muh-Lii Liang, Hsin-Hung Chen, Yi-Yen Lee, Yi-Wei Chen, Shih-Chieh Lin, Feng-Chi Chang, Min-Lan Tsai, Yen-Lin Liu, Hsin-Lun Lee, Kevin Li-Chun Hsieh, Wen-Chang Huang, Shian-Ying Sung, Che-Chang Chang, Chun Austin Changou, Kung-Hao Liang, Tsung-Han Hsieh, Yun-Ru Liu, Meng-En Chao, Wan Chen, Shing-Shung Chu, Er-Chieh Cho, Tai-Tong Wong
Article
Oncology
Muh-Lii Liang, Chun-Han Chen, Yun-Ru Liu, Man-Hsu Huang, Yu-Chen Lin, Tai-Tong Wong, Sey-En Lin, Shing-Shiung Chu, Yi-Huei Ding, Tsung-Han Hsieh
Article
Biology
Yi-Wei Chen, Yi-Yen Lee, Chun-Fu Lin, Po-Shen Pan, Jen-Kun Chen, Chun-Wei Wang, Shih-Ming Hsu, Yu-Cheng Kuo, Tien-Li Lan, Sanford P. C. Hsu, Muh-Lii Liang, Robert Hsin-Hung Chen, Feng-Chi Chang, Chih-Chun Wu, Shih-Chieh Lin, Hsiang-Kuang Liang, Jia-Cheng Lee, Shih-Kuan Chen, Hong-Ming Liu, Jinn-Jer Peir, Ko-Han Lin, Wen-Sheng Huang, Kuan-Hsuan Chen, Yu-Mei Kang, Shueh-Chun Liou, Chun-Chieh Wang, Ping-Ching Pai, Chih-Wei Li, Daniel Quah Song Chiek, Tai-Tong Wong, Shih-Hwa Chiou, Yee Chao, Hiroki Tanaka, Fong-In Chou, Koji Ono
Summary: Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters for patients with immediately life-threatening, end-stage brain tumors remain unclear. In this study, BNCT was performed on 34 patients with life-threatening, end-stage brain tumors, and the results showed promising therapeutic outcomes, especially for patients who achieved a complete response. The statistical analysis revealed the optimal BNCT parameters and tumor characteristics, providing valuable reference for clinicians conducting BNCT treatment for similar patients in the future.
Review
Biochemistry & Molecular Biology
Anh Duy Do, Ida Kurniawati, Chia-Ling Hsieh, Tai-Tong Wong, Yu-Ling Lin, Shian-Ying Sung
Summary: Treating brain tumors is challenging due to the blood-brain barrier, which limits therapeutic access. Mesenchymal stem cells can be engineered to release extracellular vesicles with healing effects, providing a cell-free approach for targeting tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yen-Lin Liu, Min-Lan Tsai, Chang- Chen, Noi Yar, Ching-Wen Tsai, Hsin-Lun Lee, Chia-Chun Kuo, Wan-Ling Ho, Kevin Li-Chun Hsieh, Sung-Hui Tseng, James S. Miser, Chia-Yau Chang, Hsi Chang, Wen-Chang Huang, Tai-Tong Wong, Alexander T. H. Wu, Yu-Chun Yen
Summary: This study analyzed the characteristics and prognosis of AT/RT patients in Taiwan. The results showed that AT/RT had a higher prevalence in males, in children < 36 months of age, and at infratentorial sites. Older age, presence of the tumor in the supratentorial region, and use of radiotherapy, chemotherapy, or both were associated with better prognosis.
Article
Biochemistry & Molecular Biology
Yi-Ping Yang, Yuh-Lih Chang, Yun-Hsien Lai, Ping-Hsing Tsai, Yu-Jer Hsiao, Long Hoang Nguyen, Xue-Zhen Lim, Chang-Chi Weng, Yu-Ling Ko, Chang-Hao Yang, De-Kuang Hwang, Shih-Jen Chen, Shih-Hwa Chiou, Guang-Yuh Chiou, An-Guor Wang, Yueh Chien
Summary: In this study, researchers found differential expression of circular RNA hsa_circ_0087207 between iPSC-derived RGCs generated from LHON patients and carriers, suggesting its involvement in the pathogenesis of LHON through the miR-665 pathway. This finding provides a novel therapeutic target for LHON treatment.
Article
Biology
Yi-Wei Chen, Yi-Yen Lee, Chun-Fu Lin, Ting-Yu Huang, Shih-Hung Ke, Pei-Fan Mu, Po-Shen Pan, Jen-Kun Chen, Tien-Li Lan, Ping-Chuan Hsu, Muh-Lii Liang, Hsin-Hung Chen, Feng-Chi Chang, Chih-Chun Wu, Shih-Chieh Lin, Jia-Cheng Lee, Shih-Kuan Chen, Hong-Ming Liu, Jinn-Jer Peir, Hui-Yu Tsai, Ko-Han Lin, Nan-Jing Peng, Kuan-Hsuan Chen, Yuan-Hung Wu, Yu-Mei Kang, Wan-Chin Yang, Shueh-Chun Liou, Wei-Hsuan Huang, Hiroki Tanaka, Tai-Tong Wong, Yee Chao, Fong-In Chou
Summary: Brainstem tumors, specifically aggressive brainstem gliomas, have a poor prognosis in children. This study explores the potential of boron neutron capture therapy (BNCT) to extend the lives of end-stage brainstem glioma patients. Two fractions of low-dose BNCT were administered to a group of life-threatening patients, with no adverse events observed. The results suggest that fractionated low-dose BNCT may be a promising treatment for end-stage brainstem tumors.
Article
Pharmacology & Pharmacy
Yu-Hone Hsu, Wei-Chung Lee, Shing-Shung Chu, Meng-En Chao, Kuo-Sheng Wu, Ren-Shyan Liu, Tai-Tong Wong
Summary: Pulsed ultrasound combined with microbubbles can temporarily disrupt the blood-brain barrier (BBB) and open a temporal window for delivering large therapeutic molecules into brain tissue. This study investigates the effects of different sonication parameters, time, and microbubble dose on BBB disruption, as well as the dynamics of BBB disruption and the efficacy of different sonication schemes. The results show that pulsed weakly focused ultrasound can extensively and reversibly open the BBB with limited brain tissue damage.
Article
Pediatrics
Tzu-Chien Chien, Mu-Ming Chien, Tsai-Ling Liu, Hsi Chang, Min-Lan Tsai, Sung-Hui Tseng, Wan-Ling Ho, Yi-Yu Su, Hsiu-Chen Lin, Jen-Her Lu, Chia-Yau Chang, Kevin Li-Chun Hsieh, Tai-Tong Wong, James S. Miser, Yen-Lin Liu
Summary: There is an increasing number of reported cases of children with neurological manifestations of COVID-19, which can resemble other potentially lethal conditions. Prompt recognition and treatment of adrenal insufficiency is crucial, especially in patients with brain tumors, Addison's disease, or recent corticosteroid treatment.
Article
Oncology
Kuo-Sheng Wu, Shian-Ying Sung, Man-Hsu Huang, Yu-Ling Lin, Che-Chang Chang, Chia-Lang Fang, Tai-Tong Wong, Hsin-Hung Chen, Min-Lan Tsai
Summary: Medulloblastoma is classified into four molecular subgroups: WNT, SHH, group 3, and group 4. This study aimed to identify the heterogeneity of molecular features and found enrichment of M2 macrophages in SHH subgroup, which may be related to good outcomes.
Meeting Abstract
Biochemistry & Molecular Biology
Tsai-Chia Lee, Yun-Hsuan Chang, Tzu-Wei Yu, Tzu-Keng Shen, Ming-Chang Tsai, Chi-Chou Huang, Tzu-Wei Yang, Chun-Che Lin, Guang-Yuh Chiou, Yuh-Jyh Jong, Jui-I Chao