Article
Infectious Diseases
Feng Huang, Wenjing Gu, Jianfeng Diwu, Xinxing Zhang, Yanyu He, Youjian Zhang, Zhengrong Chen, Li Huang, Meijuan Wang, Heting Dong, Shanshan Wang, Yuqing Wang, Canhong Zhu, Chuangli Hao
Summary: This study investigated the etiological characteristics of plastic bronchitis caused by pulmonary infections in children and found that Mycoplasma pneumoniae (MP) and Boca virus are the primary pathogens. PB cases caused by different pathogens exhibit distinct clinical features and complications.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Qian Hu, Jianle Wu, Chengqian Wang, Wen Liang, Yulei Wang, Yuejie Zheng, Feiqiu Wen, Wenjian Wang, Uet Yu
Summary: This study retrospectively analyzed data from 321 children with influenza virus pneumonia and found that patients with influenza virus infection were at higher risk for developing plastic bronchitis and had longer fever durations. Bronchoscopy can aid in the early detection and treatment of plastic bronchitis, improving the prognosis of children with this condition.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, Research & Experimental
Yanyan Wang, Shuhua An
Summary: Plastic bronchitis is a rare and potentially fatal disease characterized by acute progressive dyspnea caused by bronchial casts. Cases of children with asthma infected with influenza A virus showed rapid progression, with emergency bronchoscopy leading to significant improvement in dyspnea symptoms and successful recovery after comprehensive treatment. Early bronchoscopy for diagnosis and treatment of PB in children with asthma after influenza A virus infection can improve patient prognosis.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Virology
Nima Ghalekhani, Saied Bokaie, Sana Eybpoosh, Hesameddin Akbarein, Hamid Sharifi
Summary: Using Bayesian phylogeography analysis, this study investigates the time and path of transmission of H1N1 serotype influenza A viruses in Iran and neighboring countries. The study finds that the age of emergence of H1N1 virus in Iran is older compared to neighboring countries, and Tehran seems to have played a key role in its transmission within Iran. Continuous monitoring and screening of H1N1 virus, along with addressing gaps and shortages in virus control, are important measures to be taken.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Pediatrics
Sarah Frankl, Susan E. Coffin, Jacqueline B. Harrison, Sanjeev K. Swami, Jennifer L. McGuire
Summary: This study found that influenza-associated neurologic complications are common in children hospitalized with influenza. Seizures and encephalopathy were the most commonly identified complications, and children with pre-existing neurologic diagnoses had a higher proportion of these complications. The study suggests that vaccination, lack of seasonal influenza vaccination, and age <= 5 years are independently associated with influenza-associated neurologic complications.
JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Nguyen Cong Khanh, Ashley L. Fowlkes, Ngu Duy Nghia, Tran Nhu Duong, Ngo Huy Tu, Tran Anh Tu, Jeffrey W. McFarland, Thoa Thi Minh Nguyen, Nga Thu Ha, Philip L. Gould, Pham Ngoc Thanh, Nguyen Thi Huyen Trang, Vien Quang Mai, Phuc Nguyen Thi, Satoko Otsu, Eduardo Azziz-Baumgartner, Dang Duc Anh, A. Danielle Iuliano
Summary: Influenza burden estimates based on hospitalization data in Vietnam show higher rates among children under 5 years old and adults over 65 years old, highlighting the importance of prevention and control measures, such as vaccination, in these high-risk populations.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Veronica A. Ferrando, Marcel E. Friedrich, Shrey Gandhi, Alexander Mellmann, Doerthe Masemann, Anmari Christersson, Darisuren Anhlan, Linda Brunotte, Monika Stoll, Timm Harder, Martin Beer, Yvonne Boergeling, Stephan Ludwig
Summary: Influenza A viruses, including the H1N1pdm09 virus, cause recurrent epidemics and occasional pandemics in humans. The reassortment of these viruses in swine and their ability to replicate in human lung tissue suggest a possible zoonotic potential. Reassortment frequently occurs in the PB1, PA, and NA segments, resulting in the generation of reassortants that can reach high titers in swine lung cells.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Multidisciplinary Sciences
Tingting Li, Junyu Chen, Qingbing Zheng, Wenhui Xue, Limin Zhang, Rui Rong, Sibo Zhang, Qian Wang, Minqing Hong, Yuyun Zhang, Lingyan Cui, Maozhou He, Zhen Lu, Zhenyong Zhang, Xin Chi, Jinjin Li, Yang Huang, Hong Wang, Jixian Tang, Dong Ying, Lizhi Zhou, Yingbin Wang, Hai Yu, Jun Zhang, Ying Gu, Yixin Chen, Shaowei Li, Ningshao Xia
Summary: Influenza A viruses are a significant global threat, and this study has identified a chimeric monoclonal antibody, C12H5, that offers broad neutralization against H1N1 and H5N1 viruses. The antibody targets a specific epitope on the surface glycoprotein of the virus, leading to control of virus entry and egress. This discovery could have implications for the development of antiviral drugs and broad-protection vaccines against influenza.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Caroline Tochetto, Dennis M. M. Junqueira, Tavis K. K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. E. Cantao, Amy L. Vincent L. Baker, Rejane Schaefer
Summary: Through surveillance and analysis of swine herds in Brazil, it was found that human seasonal influenza viruses have entered the pig population at least eight different times, leading to the formation of distinct genetic subgroups. Bidirectional transmission between humans and pigs is a major contributing factor to the global genetic diversity of swine influenza viruses, highlighting the importance of surveillance.
Article
Respiratory System
Jing-jing Huang, Xiao-qing Yang, Zhi-qiang Zhuo, Lin Yuan
Summary: This study retrospectively analyzed the clinical characteristics, diagnosis, and treatment of plastic bronchitis (PB) in 43 children. It was found that PB often occurs secondary to respiratory tract infections and progresses rapidly. The main clinical manifestations of pediatric PB include hyperpyrexia, cough, and shortness of breath. Lung imaging shows pulmonary consolidation, atelectasis, and pleural effusion. Early bronchoscopy and removal of casts are effective treatment options.
RESPIRATORY RESEARCH
(2022)