Sequential Continuous Flow Processes for the Oxidation of Amines and Azides by using HOF•MeCN

The generation and use of the highly potent oxidising agent HOF.MeCN in a controlled single continuous flow process is described. Oxidations of amines and azides to corresponding nitrated systems by using fluorine gas, water and acetonitrile by sequential gasliquid/liquidliquid continuous flow procedures are reported.