Merging Allosteric and Active Site Binding Motifs: De novo Generation of Target Selectivity and Potency via Natural-Product-Derived Fragments

New Horizons for Old Drugs and Drug Leads

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Steering Target Selectivity and Potency by Fragment-Based De Novo Drug Design

(2013) Tiago Rodrigues et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strategic Targeting of Multiple Water-Mediated Interactions: A Concise and Rational Structure-Based Design Approach to Potent and Selective MMP-13 Inhibitors

(2013) Thomas Fischer et al.   ChemMedChem

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Natural-product-derived fragments for fragment-based ligand discovery

(2012) Björn Over et al.   Nature Chemistry

An MMP13-Selective Inhibitor Delays Primary Tumor Growth and the Onset of Tumor-Associated Osteolytic Lesions in Experimental Models of Breast Cancer

(2012) Manisha Shah et al.   PLoS One

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2

(2011) Chris De Savi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Hope for the Treatment of Osteoarthritis Through Selective Inhibition of MMP-13

(2011) N.-G. Li et al.   CURRENT MEDICINAL CHEMISTRY

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization

(2011) Valeria La Pietra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13

(2011) Steven J. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis

(2011) Christian Gege et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

(2011) Diego Sbardella et al.   MOLECULAR ASPECTS OF MEDICINE

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Selective MMP13 inhibitors

(2010) Jie Jack Li et al.   MEDICINAL RESEARCH REVIEWS

Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis

(2009) A. Jungel et al.   ANNALS OF THE RHEUMATIC DISEASES

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

(2009) Vijaykumar M. Baragi et al.   ARTHRITIS AND RHEUMATISM

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

(2009) Mark E. Schnute et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

(2008) Gillian Murphy et al.   Nature clinical practice. Rheumatology