Aptamers as Drug Delivery Vehicles

An Aptamer–siRNA Chimera Silences the Eukaryotic Elongation Factor 2 Gene and Induces Apoptosis in Cancers Expressing αvβ3 Integrin

(2015) Ahmad Fawzi Hussain et al.   Nucleic Acid Therapeutics

DNA-Hybrid-Gated Multifunctional Mesoporous Silica Nanocarriers for Dual-Targeted and MicroRNA-Responsive Controlled Drug Delivery

(2014) Penghui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AS1411 Aptamer and Folic Acid Functionalized pH-Responsive ATRP Fabricated pPEGMA–PCL–pPEGMA Polymeric Nanoparticles for Targeted Drug Delivery in Cancer Therapy

(2014) Shantanu V. Lale et al.   BIOMACROMOLECULES

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

(2014) Liyu Li et al.   BIOMATERIALS

Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery

(2014) Phapanin Charoenphol et al.   MOLECULAR PHARMACEUTICS

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

(2014) Carla L Esposito et al.   MOLECULAR THERAPY

Stabilized Interleukin-6 receptor binding RNA aptamers

(2014) Cindy Meyer et al.   RNA Biology

Chlorin e6 Conjugated Interleukin-6 Receptor Aptamers Selectively Kill Target Cells Upon Irradiation

(2014) Sven Kruspe et al.   Molecular Therapy-Nucleic Acids

Engineering a Cell-Surface Aptamer Circuit for Targeted and Amplified Photodynamic Cancer Therapy

(2013) Da Han et al.   ACS Nano

Overexpression of nucleolin and different expression sites both related to the prognosis of gastric cancer

(2013) Wensheng Qiu et al.   APMIS

A polyvalent aptamer system for targeted drug delivery

(2013) Zhiqing Zhang et al.   BIOMATERIALS

The anti-chemoresistant effect and mechanism of MUC1 aptamer–miR-29b chimera in ovarian cancer

(2013) Furong Dai et al.   GYNECOLOGIC ONCOLOGY

A cell-based single-stranded DNA aptamer specifically targets gastric cancer

(2013) Xiaojiao Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A HER2-targeted RNA aptamer molecule labeled with 99mTc for single-photon imaging in malignant tumors

(2013) Kambiz Varmira et al.   NUCLEAR MEDICINE AND BIOLOGY

Aptamer imaging with Cu-64 labeled AS1411: Preliminary assessment in lung cancer

(2013) Junling Li et al.   NUCLEAR MEDICINE AND BIOLOGY

Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells

(2013) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

(2013) G. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Ultra pH-Sensitive and Aptamer-Equipped Nanoscale Drug-Delivery System for Selective Killing of Tumor Cells

(2013) Nianxi Zhao et al.   Small

Photosensitizer-Gold Nanorod Composite for Targeted Multimodal Therapy

(2013) Jian Wang et al.   Small

Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages

(2013) Olcay Boyacioglu et al.   Molecular Therapy-Nucleic Acids

In vivo SELEX for Identification of Brain-penetrating Aptamers

(2013) Congsheng Cheng et al.   Molecular Therapy-Nucleic Acids

Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy

(2012) Jian Wang et al.   ACS Nano

Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities

(2012) Zeyu Xiao et al.   ACS Nano

Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection

(2012) Zeyu Xiao et al.   ACS Nano

Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles

(2012) Huile Gao et al.   BIOMATERIALS

AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery

(2012) Athulya Aravind et al.   BIOTECHNOLOGY AND BIOENGINEERING

Reversal of Paclitaxel Resistance in Epithelial Ovarian Carcinoma Cells by a MUC1 Aptamer-let-7i Chimera

(2012) Nenghui Liu et al.   CANCER INVESTIGATION

Targeting cancer cells with controlled release nanocapsules based on a single aptamer

(2012) Frank J. Hernandez et al.   CHEMICAL COMMUNICATIONS

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery

(2012) Hang Xing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2-positive Breast Cancer Cells in Vitro

(2012) Zhe Liu et al.   Journal of Translational Medicine

Design of Enzyme-Mediated Controlled Release Systems Based on Silica Mesoporous Supports Capped with Ester-Glycol Groups

(2012) Alessandro Agostini et al.   LANGMUIR

Prodrug Strategy for PSMA-Targeted Delivery of TGX-221 to Prostate Cancer Cells

(2012) Yunqi Zhao et al.   MOLECULAR PHARMACEUTICS

Targeting Axl With an High-affinity Inhibitory Aptamer

(2012) Laura Cerchia et al.   MOLECULAR THERAPY

Targeted quantum dots fluorescence probes functionalized with aptamer and peptide for transferrin receptor on tumor cells

(2012) Ming-Zhen Zhang et al.   NANOTECHNOLOGY

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

(2012) Kristina W. Thiel et al.   NUCLEIC ACIDS RESEARCH

Novel MUC1 Aptamer Selectively Delivers Cytotoxic Agent to Cancer Cells In Vitro

(2012) Yan Hu et al.   PLoS One

Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection

(2012) William H. Thiel et al.   PLoS One

Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells

(2012) Cindy Meyer et al.   RNA Biology

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Anticancer role of MUC1 aptamer–miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation

(2012) Furong Dai et al.   Targeted Oncology

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition

(2012) Alexey Berezhnoy et al.   Molecular Therapy-Nucleic Acids

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

(2012) Samantha E Wilner et al.   Molecular Therapy-Nucleic Acids

siRNA-Aptamer Chimeras on Nanoparticles: Preserving Targeting Functionality for Effective Gene Silencing

(2011) Vaishali Bagalkot et al.   ACS Nano

Smart Multifunctional Nanostructure for Targeted Cancer Chemotherapy and Magnetic Resonance Imaging

(2011) Tao Chen et al.   ACS Nano

Aptamer-Conjugated DNA Icosahedral Nanoparticles As a Carrier of Doxorubicin for Cancer Therapy

(2011) Microsugar Chang et al.   ACS Nano

Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle

(2011) Jin Kyeoung Kim et al.   BIOMATERIALS

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

High-Intensity Fluorescence Imaging and Sensitive Electrochemical Detection of Cancer Cells by using an Extracellular Supramolecular Reticular DNA-Quantum Dot Sheath

(2011) Hua Zhong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Solution structure of a truncated anti-MUC1 DNA aptamer determined by mesoscale modeling and NMR

(2011) Meriem Baouendi et al.   FEBS Journal

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

(2011) Xiaohua Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted chemoimmunotherapy using drug-loaded aptamer–dendrimer bioconjugates

(2011) In-Hyun Lee et al.   JOURNAL OF CONTROLLED RELEASE

Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer

(2011) Ronak Savla et al.   JOURNAL OF CONTROLLED RELEASE

One-pot synthesis of sustained-released doxorubicin silica nanoparticles for aptamer targeted delivery to tumor cells

(2011) Xiaoxiao He et al.   Nanoscale

Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs

(2011) Kotb Abdelmohsen et al.   NUCLEIC ACIDS RESEARCH

Novel Aptamer-Nanoparticle Bioconjugates Enhances Delivery of Anticancer Drug to MUC1-Positive Cancer Cells In Vitro

(2011) Chenchen Yu et al.   PLoS One

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Rational Truncation of an RNA Aptamer to Prostate-Specific Membrane Antigen Using Computational Structural Modeling

(2011) William M. Rockey et al.   Nucleic Acid Therapeutics

A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma

(2011) Nianxi Zhao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

(2010) Yen-An Shieh et al.   ACS Nano

Exceptionally High Payload of Doxorubicin in Hollow Gold Nanospheres for Near-Infrared Light-Triggered Drug Release

(2010) Jian You et al.   ACS Nano

Where Are All the Aptamers?

(2010) Geoffrey S. Baird   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Applications of Aptamers as Sensors

(2010) Eun Jeong Cho et al.   Annual Review of Analytical Chemistry

Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex

(2010) Eunjung Kim et al.   BIOMATERIALS

The formulation of aptamer-coated paclitaxel–polylactide nanoconjugates and their targeting to cancer cells

(2010) Rong Tong et al.   BIOMATERIALS

Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (−) prostate cancers

(2010) Kyoungin Min et al.   BIOMATERIALS

A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism

(2010) E. M. Reyes-Reyes et al.   CANCER RESEARCH

Aptamer conjugated magnetic nanoparticles as nanosurgeons

(2010) Baiju G Nair et al.   NANOTECHNOLOGY

Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

(2010) Fernando Pastor et al.   NATURE

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

(2010) Günter Mayer et al.   Nature Protocols

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Lipidic Systems for In Vivo siRNA Delivery

(2009) Sherry Y. Wu et al.   AAPS Journal

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

The new face of nucleolin in human melanoma

(2009) Dorota Hoja-Łukowicz et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

(2009) Yu-Fen Huang et al.   CHEMBIOCHEM

A liposome-based nanostructure for aptamer directed delivery

(2009) Huaizhi Kang et al.   CHEMICAL COMMUNICATIONS

Directed evolution of gold nanoparticle delivery to cells

(2009) Na Li et al.   CHEMICAL COMMUNICATIONS

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Aptamer–biotin–streptavidin–C1q complexes can trigger the classical complement pathway to kill cancer cells

(2009) John Gordon Bruno   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer

(2009) Seyed Mohammad Taghdisi et al.   JOURNAL OF DRUG TARGETING

A Nucleolin-Targeted Multimodal Nanoparticle Imaging Probe for Tracking Cancer Cells Using an Aptamer

(2009) D. W. Hwang et al.   JOURNAL OF NUCLEAR MEDICINE

Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles

(2009) Gary J. Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Cell Targeting Using Multiple Aptamers Conjugated on Nanorods

(2008) Yu-Fen Huang et al.   ANALYTICAL CHEMISTRY

Enrichment of Cell‐Targeting and Population‐Specific Aptamers by Fluorescence‐Activated Cell Sorting

(2008) Marie‐Sophie L. Raddatz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

(2008) Andrew Z. Wang et al.   ChemMedChem

Cell-Specific Induction of Apoptosis by Rationally Designed Bivalent Aptamer-siRNA Transcripts Silencing Eukaryotic Elongation Factor 2

(2008) Ulrich Wullner et al.   CURRENT CANCER DRUG TARGETS

Selective Photothermal Therapy for Mixed Cancer Cells Using Aptamer-Conjugated Nanorods

(2008) Yu-Fen Huang et al.   LANGMUIR

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Phototoxic aptamers selectively enter and kill epithelial cancer cells

(2008) Cátia S. M. Ferreira et al.   NUCLEIC ACIDS RESEARCH

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer-based endocytosis of a lysosomal enzyme

(2008) C.-h. B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

(2008) F. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanotechnology and aptamers: applications in drug delivery

(2008) Etgar Levy-Nissenbaum et al.   TRENDS IN BIOTECHNOLOGY

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY

Cell Specific Aptamer–Photosensitizer Conjugates as a Molecular Tool in Photodynamic Therapy

(2007) Prabodhika Mallikaratchy et al.   ChemMedChem