Potent and Selective Inhibition of Cysteine Proteases fromPlasmodium falciparumandTrypanosoma brucei

Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series†

(2010) Jose M. Coterón et al.   JOURNAL OF MEDICINAL CHEMISTRY

Michael Acceptor Based Antiplasmodial and Antitrypanosomal Cysteine Protease Inhibitors with Unusual Amino Acids

(2010) Alexander Breuning et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei

(2010) Iain D. Kerr et al.   PLoS Neglected Tropical Diseases

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

(2009) Iain D. Kerr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity‡

(2009) Iain D. Kerr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

Plasmodium Food Vacuole Plasmepsins Are Activated by Falcipains

(2008) Mark E. Drew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Drug Design: Exploring the Proper Filling of Apolar Pockets at Enzyme Active Sites

(2008) Martina Zürcher et al.   JOURNAL OF ORGANIC CHEMISTRY

RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model

(2008) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases