Journal
ACS CHEMICAL BIOLOGY
Volume 4, Issue 12, Pages 983-985Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb900304p
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An improved method for the semi-synthesis of a potassium channel Involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.
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