Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering

Efficient labelling of enzymatically synthesized vinyl-modified DNA by an inverse-electron-demand Diels–Alder reaction

(2014) Holger Bußkamp et al.   CHEMICAL COMMUNICATIONS

Improved cyclopropene reporters for probing protein glycosylation

(2014) David M. Patterson et al.   Molecular BioSystems

Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels–Alder Ligation

(2014) Sander B. Engelsma et al.   ORGANIC LETTERS

Preparation of Small-Molecule Microarrays bytrans-Cyclooctene Tetrazine Ligation and Their Application in the High-Throughput Screening of Protein-Protein Interaction Inhibitors of Bromodomains

(2013) Chong-Jing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry

(2013) Andrea Niederwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Imaging Cell Surface Glycosylation in Vivo Using “Double Click” Chemistry

(2013) André A. Neves et al.   BIOCONJUGATE CHEMISTRY

Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter

(2013) Anne-Katrin Späte et al.   BIOCONJUGATE CHEMISTRY

Metabolic Glycan Imaging by Isonitrile-Tetrazine Click Chemistry

(2013) Shaun Stairs et al.   CHEMBIOCHEM

Fluorescent Live-Cell Imaging of Metabolically Incorporated Unnatural Cyclopropene-Mannosamine Derivatives

(2013) Christian M. Cole et al.   CHEMBIOCHEM

Inverse electron demand Diels–Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme

(2013) Astrid-Caroline Knall et al.   CHEMICAL SOCIETY REVIEWS

Expanding room for tetrazine ligations in the in vivo chemistry toolbox

(2013) Jolita Šečkutė et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dual-sugar imaging using isonitrile and azido-based click chemistries

(2013) Yéléna A. Wainman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities

(2012) Lianne I. Willems et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction

(2012) Emine Kaya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amino Acids for Diels-Alder Reactions in Living Cells

(2012) Tilman Plass et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific One-Pot Dual Labeling of DNA by Orthogonal Cycloaddition Chemistry

(2012) Juliane Schoch et al.   BIOCONJUGATE CHEMISTRY

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation

(2012) Leslie A. Bateman et al.   CHEMICAL COMMUNICATIONS

Preparation of Carbohydrate Arrays by Using Diels-Alder Reactions with Inverse Electron Demand

(2012) Henning S. G. Beckmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

TMZ-BioShuttle – a reformulated Temozolomide

(2012) Waldemar Waldeck et al.   International Journal of Medical Sciences

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

(2012) Kathrin Lang et al.   Nature Chemistry

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging

(2011) Mark R. Karver et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

(2011) Weixuan Chen et al.   CHEMICAL COMMUNICATIONS

Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine–trans-Cyclooctene Ligation

(2011) Michael T. Taylor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1

(2011) B. W. Zaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic cross-talk allows labeling of O-linked  -N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway

(2011) M. Boyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

(2010) Raffaella Rossin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells

(2010) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Post-Synthetic Modification of DNA by Inverse-Electron-Demand Diels−Alder Reaction

(2010) Juliane Schoch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic glycoengineering: Sialic acid and beyond

(2009) Jian Du et al.   GLYCOBIOLOGY

Inverse-electron-demand Diels-Alder reaction as a highly efficient chemoselective ligation procedure: Synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells

(2009) Rüdiger Pipkorn et al.   JOURNAL OF PEPTIDE SCIENCE

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY