Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao, Shaohua Gou
Summary: This article presents a rational design of half-sandwich Ru(II) complexes for mitochondria-targeted anticancer and antimetastatic agents by introducing the NDI unit into the N,N-chelating ligand of these complexes, which exhibit excellent emission performance. These complexes have potential applications in the design of multifunctional theranostic agents and fluorescent biomarkers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Eiji Kudo, Yuki Oba, Koji Yamamoto, Tetsuro Murahashi
Summary: We report on di- and trinuclear palladium sandwich complexes of cross-pi-conjugated fulvenes. Structural and theoretical analysis demonstrated that the fulvene sandwich framework possesses a metal-metal bonded moiety, with strong donation and back-donation observed in the dinuclear and trinuclear bonds, respectively. The trinuclear fulvene sandwich complex exhibits a unique reversible extrusion of a Pd atom from inside to outside the sandwich framework.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Konstantinos Ypsilantis, Theodoros Tsolis, Achilleas Garoufis
Summary: The synthesis and characterization of (RuCp)-[12]CycloParaPhenylene complexes with varying numbers of (RuCp) substitutions were achieved by controlling the reaction molar ratio. UV irradiation led to the release of (RuCp) solvolyzed species which formed adducts with 9-MeG in an aqueous solution, showing potential applications in cancer photodynamic therapy using full-sandwich ruthenium-arene complexes.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Nuria Alvarez-Pazos, Jorge Bravo, Ana M. Grana, Soledad Garcia-Fontan
Summary: A series of new half-sandwich mixed phosphine-phosphinite ruthenium complexes and related compounds were prepared and thoroughly characterized in this study.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Dana Josa, David Aguila, Pere Fontova, Vanessa Soto-Cerrato, Piedad Herrera-Ramirez, Laia Rafols, Arnald Grabulosa, Patrick Gamez
Summary: Five metal-arene complexes and nine cyclometalated half-sandwich complexes were synthesized, characterized, and evaluated for cytotoxicity against human cancer cells. The complexes showed notable cytotoxic properties, particularly against lung adenocarcinoma cells. One of the complexes also exhibited significant toxic effects on other cell lines. Furthermore, the study identified a complex that impacted the cell cycle of lung adenocarcinoma cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Abraha Habtemariam, Ana M. Pizarro
Summary: This study introduces a new family of osmium arene complexes and investigates their mechanism of action inside cells. The complexes are shown to catalyze the conversion of organic substrates, demonstrating potential anti-cancer drug activity.
Article
Chemistry, Inorganic & Nuclear
Wen-Rui Lv, Rong-Jian Li, Zhen-Jiang Liu, Yan Jin, Zi-Jian Yao
Summary: A series of N,O-coordinate iridium(III) complexes with Schiff base ligands were synthesized for catalytic hydrogenation of nitro and carbonyl substrates, showing efficient catalytic activity and high yields. The molecular structures of the complexes were well characterized and the highest TON values were achieved for the hydrogenation reactions of carbonyl and nitro substrates.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Angelica E. Graminha, Cecilia Popolin, Joao Honorato de Araujo-Neto, Rodrigo S. Correa, Katia M. de Oliveira, Luani R. Godoy, Legna Colina Vegas, Javier Ellena, Alzir A. Batista, Marcia R. Cominetti
Summary: In this work, new ruthenium compounds with specific ligands were synthesized and characterized. The properties of these compounds in different solvents were studied, and their cytotoxicity against breast tumor cells and non-tumor cell lines was evaluated. One specific compound showed excellent selectivity towards the MDA-MB-231 cell line and induced apoptosis through the intrinsic pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Rais Ahmad Khan, Amal AlFawaz, Nida N. Farshori, Anup Paul, Mohammed H. Jaafar, Ali Alsalme
Summary: Two organometallic ruthenium (II) complexes containing analogs of aminobenzimidazole were synthesized and characterized. Their binding affinity with human serum albumin and cytotoxic potential against cancer cells were evaluated. One of the complexes showed promising cytotoxic properties, indicating its potential as an anticancer therapeutic.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Darina Muthna, Petr Halas, Pavel Zoufaly, Eva Peterova, Radim Havelek, Bohuslav Drahos, David Milde, Alena Mrkvicova, Pavel Starha
Summary: In the presence of carboxypeptidase, the hydrolytically stable complex partially released the bioactive substituent indomethacin, which was bound through the amide bond to the chelating moiety. The stability in the presence of other relevant biomolecules and cancer cell viability were also investigated in this study.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
M. C. Joseph, A. J. Swarts, S. F. Mapolie
Summary: A series of novel cationic ruthenium half-sandwich complexes with 1-substituted-4-pyridyl-1H-1,2,3-triazole ligands were synthesized and found to be efficient catalyst precursors for transfer hydrogenation reactions. With a low concentration of base, these complexes could hydrogenate acetophenone with excellent conversions within a short reaction time. The catalytic efficiency of the most effective catalyst was further demonstrated in the transfer hydrogenation of a small library of ketones.
Article
Biochemistry & Molecular Biology
Carley Giffert L. Nongpiur, Akalesh Kumar Verma, Rohit Kumar Singh, Mayur Mohan Ghate, Krishna Mohan Poluri, Werner Kaminsky, Mohan Rao Kollipara
Summary: A series of new complexes of ruthenium(II), rhodium(III), and iridium(III) with pyrazoline-based ligands were synthesized and characterized. These compounds exhibited good antibacterial activity against Gram-positive bacteria and moderate antioxidant activity. They also showed moderate affinity for binding to Salmon Milt DNA and demonstrated higher cytotoxicity in Dalton's lymphoma cell lines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuyuan Xiao, Xiao-Kun Zhao, Tianpin Wu, Jeffrey T. Miller, Han-Shi Hu, Jun Li, Wenliang Huang, Paula L. Diaconescu
Summary: In this study, inverse-sandwich samarium and ytterbium biphenyl complexes were synthesized and their structures and interactions with potassium were investigated. Spectroscopic and computational studies revealed differences in bonding interactions with biphenyl between ytterbium and samarium ions.
Article
Chemistry, Organic
Marc Petit, Cassandre C. Bories, Geoffrey Gontard, Marion Barbazanges, Etienne Derat
Summary: We achieved an efficient regio- and chemoselective dearomatization of N-heteroarenes using hydrido-cobalt catalysts. Mild conditions were employed and the reaction exclusively produced the silyl-1,2-dihydroheteroarenes in a wide range of N-heteroarenes. Quinolines and pyridines with electron-donating and electron-withdrawing substituents were compatible with this methodology. DFT calculations, NMR spectroscopic studies, and X-ray diffraction analysis demonstrated the importance of a second silane for the final step of the reaction.
Article
Chemistry, Applied
Marcel Annereau, Franck Martial, Jeremy Forte, Geoffrey Gontard, Sebastien Blanchard, Heloise Dossmann, Michele Salmain, Vincent Corce
Summary: A series of manganese(I) tricarbonyl complexes were synthesized and characterized, which could be easily obtained from a common dimeric structure. These complexes, when reacted with imidazole derivatives, led to the formation of monomeric complexes with various functional groups. Photoactivation of these complexes resulted in the release of CO, with the mechanism of CO release explored through spectroscopic and computational methods. A manganese complex containing a more elaborate imidazole ligand was successfully synthesized, allowing for its direct incorporation in peptides.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Marion Poncet, Ang Li, Geoffrey Gontard, Lise-Marie Chamoreau, Yanling Li, Laurent Lisnard, Jurgen Von Bardeleben, Sourav Dey, Gopalan Rajaraman, Yves Journaux
Summary: The reaction of multi-bidentate oxamate-based copper(II) complexes with [Ni((i)Prtacn)Cl-2] complex has been studied. X-ray diffraction studies reveal the formation of trimetallic {CuNi2}, hexametallic {Cu2Ni4} and enneametallic {Cu3Ni6} complexes. The investigation of magnetic properties shows that Cu-Ni interactions through the oxamato bridge are in the expected range. The DFT calculations agree with the experimental results on the magnetic couplings of 1-3.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Alfonso Annunziata, Maria Elena Cucciolito, Maddalena Di Ronza, Giarita Ferraro, Mouna Hadiji, Antonello Merlino, Daniel Ortiz, Rosario Scopelliti, Farzaneh Fadaei Tirani, Paul J. Dyson, Francesco Ruffo
Summary: This article reports a series of Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring and an N-heterocyclic carbene(NHC)-carbene ligand with a peracetylated glucose moiety. The complexes undergo hydrolysis in water and show reactivity towards model nucleophiles and biological macromolecules. However, they exhibit low anti-tumor activity against human ovarian carcinoma cells and cisplatin-resistant cells.
Article
Chemistry, Multidisciplinary
Shunlin Zhang, Yuxin Xie, Rosie J. J. Somerville, Farzaneh Fadaei Tirani, Rosario Scopelliti, Zhaofu Fei, Dunru Zhu, Paul J. J. Dyson
Summary: This study reports a new family of proton conductors based on MIL-101 and protic ionic liquid polymers (PILPs) containing different anions. The PILP@MIL-101 composites maintain the nanoporous cavities and water stability of MIL-101, while providing much-improved proton transport. The PILP@MIL-101 composite with HSO4- anions shows superprotonic conductivity (6.3 x 10(-2) S cm(-1)) at 85 degrees C and 98% relative humidity.
Article
Chemistry, Multidisciplinary
Haodan Guo, Yanyan Fang, Yan Lei, Jinpeng Wu, Minghua Li, Xiangrong Li, Hong Bo Cheng, Yuan Lin, Paul J. Dyson
Summary: This study demonstrates the use of a self-assembled ionic insulating layer to improve the performance of wide-bandgap perovskite solar cells. The layer effectively suppresses halide phase separation, reducing open-circuit voltage loss and improving device stability.
Article
Multidisciplinary Sciences
Mingyang Liu, Paul J. Dyson
Summary: Efficient valorization of lignin, a sustainable and renewable source, is essential for reducing dependence on fossil-derived feedstocks. This study presents a highly efficient strategy for extracting aromatic monomers and generating functionalized diaryl ethers from lignin using oxidative cross-coupling reactions.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Anthony Nina-Diogo, Benoit Bertrand, Serge Thorimbert, Geoffrey Gontard, Sehr Nassem-Kahn, Andrea Echeverri, Julia Contreras-Garcia, Clemence Allain, Gilles Lemercier, Eleonora Luppi, Candice Botuha
Summary: This report presents the design, synthesis, and photophysical study of two new series of promising fluorescent trisubstituted triazoles, PyOHTr and PyCOTr. The PyOHTr molecules were found to exhibit an excited state intramolecular proton transfer (ESIPT) fluorescence mechanism through ab initio theoretical calculations. These fluorescent dyes possess unique optical properties with potential applications in medicinal chemistry and materials science.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Chemistry, Multidisciplinary
Cassandre Cassiopee Bories, Geoffrey Gontard, Marion Barbazanges, Gilles Lemiere, Marc Petit
Summary: In this study, a mild stereo- and regioselective dearomatization of quinolines using a low-valent HCo(N-2)(PPh3)(3) complex was reported. The authors developed conditions to selectively form high-valued 1,4-bis-borylated tetrahydroquinolines at room temperature from simple starting heteroaromatic compounds. The reaction mechanism involves a cascade pathway, and DFT calculations provided insights into the selectivity of the reaction.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yaping Cheng, Geoffrey Gontard, Abderrahim Khatyr, Michael Knorr, Hani Amouri
Summary: Luminescent N-heterocyclic carbene chloride copper (I) complexes incorporating pyrene chromophore (1-Pyrenyl-NHC-R)-Cu-Cl with different substituents (methyl or naphthyl) were synthesized and characterized. X-ray diffraction confirmed the formation of the target compounds. These compounds exhibited blue emission in both solution and solid-state at room temperature, with comparable or higher quantum yields than the parent pyrene molecule. Notably, the quantum yield was increased by almost two-fold by replacing the methyl group with a naphthyl group. These compounds show potential for applications in optical displays.
Article
Chemistry, Organic
Anissa Beghennou, Geoffrey Gontard, Heloise Dossmann, Kevin Passador, Serge Thorimbert, Vincent Corce, Candice Botuha
Summary: Efficient synthesis of original 1,6-naphthyridin-7(6H)-ones and their optical properties, including dual fluorescence, solvatochromism, acidochromism, large Stokes shifts, and high quantum yields, are described in this study. These properties make them suitable for biological applications or as luminescent devices in materials science.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
