Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: New Insights into the Role of Leader and Core Peptides during Biosynthesis

Revealing Nature’s Synthetic Potential Through the Study of Ribosomal Natural Product Biosynthesis

(2013) Kyle L. Dunbar et al.   ACS Chemical Biology

Mechanistic Aspects of Lanthipeptide Leaders

(2013) Annechien Plat et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Biosynthesis of the Class III Lantipeptide Catenulipeptin

(2012) Huan Wang et al.   ACS Chemical Biology

Discovery, Biosynthesis, and Engineering of Lantipeptides

(2012) Patrick J. Knerr et al.   Annual Review of Biochemistry

Generation of an actagardine A variant library through saturation mutagenesis

(2012) Steven Boakes et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural Characterization of Four Prochlorosins: A Novel Class of Lantipeptides Produced by Planktonic Marine Cyanobacteria

(2012) Weixin Tang et al.   BIOCHEMISTRY

When the Leader Gets Loose: In Vivo Biosynthesis of a Leaderless Prenisin Is Stimulated by atrans-Acting Leader Peptide

(2012) Rustem Khusainov et al.   CHEMBIOCHEM

Sequence Determinants Governing the Topology and Biological Activity of a Lasso Peptide, Microcin J25

(2012) Rémi Ducasse et al.   CHEMBIOCHEM

Dissecting the Maturation Steps of the Lasso Peptide Microcin J25 in vitro

(2012) Kok-Phen Yan et al.   CHEMBIOCHEM

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli

(2012) Yanxiang Shi et al.   CHEMICAL COMMUNICATIONS

Structures of Cyanobactin Maturation Enzymes Define a Family of Transamidating Proteases

(2012) Vinayak Agarwal et al.   CHEMISTRY & BIOLOGY

Codon Randomization for Rapid Exploration of Chemical Space in Thiopeptide Antibiotic Variants

(2012) Travis S. Young et al.   CHEMISTRY & BIOLOGY

Synthetic Biotechnology to Study and Engineer Ribosomal Bottromycin Biosynthesis

(2012) Liujie Huo et al.   CHEMISTRY & BIOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate

(2012) Trent J. Oman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deuterium Labeled Peptides Give Insights into the Directionality of Class III Lantibiotic Synthetase LabKC

(2012) Bartlomiej Krawczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selectivity, Directionality, and Promiscuity in Peptide Processing from a Bacillus sp. Al Hakam Cyclodehydratase

(2012) Joel O. Melby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lasso peptides: structure, function, biosynthesis, and engineering

(2012) Mikhail O. Maksimov et al.   NATURAL PRODUCT REPORTS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations

(2012) Kyle L Dunbar et al.   Nature Chemical Biology

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A

(2012) Leif Flühe et al.   Nature Chemical Biology

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

(2012) Jesko Koehnke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and Biosynthesis of the Antibiotic Bottromycin D

(2012) Yanpeng Hou et al.   ORGANIC LETTERS

Evolution of lanthipeptide synthetases

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precursor-centric genome-mining approach for lasso peptide discovery

(2012) M. O. Maksimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: expanding the biosynthetic diversity of ribosomal peptides

(2012) William J. K. Crone et al.   Chemical Science

Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks

(2011) Christopher T. Walsh et al.   ACS Chemical Biology

The 3D Solution Structure of Thurincin H, a Bacteriocin with Four Sulfur to α-Carbon Crosslinks

(2011) Clarissa S. Sit et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist

(2011) Thomas A. Knappe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC

(2011) Wolfgang M. Müller et al.   BIOCHEMISTRY

Construction of a Single Polypeptide that Matures and Exports the Lasso Peptide Microcin J25

(2011) Si Jia Pan et al.   CHEMBIOCHEM

Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function

(2011) Chaoxuan Li et al.   CHEMICAL COMMUNICATIONS

Leader Peptide and a Membrane Protein Scaffold Guide the Biosynthesis of the Tricyclic Peptide Microviridin

(2011) Annika R. Weiz et al.   CHEMISTRY & BIOLOGY

Linking Chemistry and Genetics in the Growing Cyanobactin Natural Products Family

(2011) Mohamed S. Donia et al.   CHEMISTRY & BIOLOGY

Biosynthesis of the Antimicrobial Peptide Epilancin 15X and Its N-Terminal Lactate

(2011) Juan E. Velásquez et al.   CHEMISTRY & BIOLOGY

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates

(2011) Joel O Melby et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Lantibiotic Transporter Requires Cooperative Functioning of the Peptidase Domain and the ATP Binding Domain

(2011) Mami Nishie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Recognition and Specificity of the NisB Protein, the Lantibiotic Dehydratase Involved in Nisin Biosynthesis

(2011) Antonino Mavaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal Route to Small-Molecule Diversity

(2011) Ma. Diarey B. Tianero et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence Diversity in the Lasso Peptide Framework: Discovery of Functional Microcin J25 Variants with Multiple Amino Acid Substitutions

(2011) Si Jia Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The 3D Structure of Thuricin CD, a Two-Component Bacteriocin with Cysteine Sulfur to α-Carbon Cross-links

(2011) Clarissa S. Sit et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic Basis of Ribosomal Peptide Prenylation in Cyanobacteria

(2011) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nine Post-translational Modifications during the Biosynthesis of Cinnamycin

(2011) Ayşe Ökesli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Determining sites of interaction between prenisin and its modification enzymes NisB and NisC

(2011) Rustem Khusainov et al.   MOLECULAR MICROBIOLOGY

Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

(2010) Kathrin Meindl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Production of a Class II Two-Component Lantibiotic of Streptococcus pneumoniae Using the Class I Nisin Synthetic Machinery and Leader Sequence

(2010) J. A. Majchrzykiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides

(2010) Gert N. Moll et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage

(2010) Annechien Plat et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria

(2010) Kaarina Sivonen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bottromycin derivatives: Efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities

(2010) Yutaka Kobayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An Experimental and Computational Investigation of Spontaneous Lasso Formation in Microcin J25

(2010) Andrew L. Ferguson et al.   BIOPHYSICAL JOURNAL

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

(2010) Daniel H Haft et al.   BMC BIOLOGY

Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1-34

(2010) Wael E. Houssen  et al.   CHEMBIOCHEM

Azole-Based Cyclic Peptides from the Sea Squirt Lissoclinum Patella: Old Scaffolds, New Avenues

(2010) Wael E. Houssen et al.   CHEMBIOCHEM

Plantazolicin, a Novel Microcin B17/Streptolysin S-Like Natural Product from Bacillus amyloliquefaciens FZB42

(2010) R. Scholz et al.   JOURNAL OF BACTERIOLOGY

Crystal Structure of the Peptidase Domain ofStreptococcusComA, a Bifunctional ATP-binding Cassette Transporter Involved in the Quorum-sensing Pathway

(2010) Seiji Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Heterocyclization from Two Highly Similar Enzymes

(2010) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge

(2010) Toshiyuki Hamada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Much of the Microcin J25 Leader Peptide is Dispensable

(2010) Wai Ling Cheung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Manipulation of Thiocillin Variants by Prepeptide Gene Replacement: Structure, Conformation, and Activity of Heterocycle Substitution Mutants

(2010) Albert A. Bowers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst

(2010) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterologous production of thiostrepton A and biosynthetic engineering of thiostrepton analogs

(2010) Chaoxuan Li et al.   Molecular BioSystems

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY

Substrate Specificity and Scope of MvdD, a GRASP-like Ligase from the Microviridin Biosynthetic Gene Cluster

(2009) Benjamin Philmus et al.   ACS Chemical Biology

Structure Determination and Total Synthesis of Bottromycin A2: A Potent Antibiotic against MRSA and VRE

(2009) Hiroyuki Shimamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of modification enzyme NukM and engineering of a novel thioether bridge in lantibiotic nukacin ISK-1

(2009) Kouki Shioya et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

(2009) Antony N. Appleyard et al.   CHEMISTRY & BIOLOGY

Insights into the Biosynthesis and Stability of the Lasso Peptide Capistruin

(2009) Thomas A. Knappe et al.   CHEMISTRY & BIOLOGY

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Directionality and Coordination of Dehydration and Ring Formation during Biosynthesis of the Lantibiotic Nisin

(2009) Jacek Lubelski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S

(2009) Douglas A. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distributive and Directional Behavior of Lantibiotic Synthetases Revealed by High-Resolution Tandem Mass Spectrometry

(2009) M. Violet Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generation of Thiocillin Variants by Prepeptide Gene Replacement and in Vivo Processing byBacillus cereus

(2009) Michael G. Acker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse Substrates

(2009) Jaeheon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning

(2009) Mohammad R. Islam et al.   MOLECULAR MICROBIOLOGY

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

(2009) John A. McIntosh et al.   NATURAL PRODUCT REPORTS

Synthesis at the molecular frontier

(2009) Paul A. Wender et al.   NATURE

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Mapping and identification of the region and secondary structure required for the maturation of the nukacin ISK-1 prepeptide

(2009) Jun-ichi Nagao et al.   PEPTIDES

Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom-Forming Cyanobacteria

(2008) Nadine Ziemert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distinct Contributions of the Nisin Biosynthesis Enzymes NisB and NisC and Transporter NisT to Prenisin Production by Lactococcus lactis

(2008) H. B. van den Berg van Saparoea et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Substrate Recognition Mechanism of the Peptidase Domain of the Quorum-Sensing-Signal−Producing ABC Transporter ComA fromStreptococcus†

(2008) Yatsugu Kotake et al.   BIOCHEMISTRY

In VitroReconstitution and Substrate Specificity of a Lantibiotic Protease†

(2008) L. A. Furgerson Ihnken et al.   BIOCHEMISTRY

The Importance of the Leader Sequence for Directing Lanthionine Formation in Lacticin 481†

(2008) Gregory C. Patton et al.   BIOCHEMISTRY

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

(2008) Matthew R. Levengood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Post-translational Modification in Microviridin Biosynthesis

(2008) Benjamin Philmus et al.   CHEMBIOCHEM

Systematic Structure-Activity Analysis of Microcin J25

(2008) Olga Pavlova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E264

(2008) Thomas A. Knappe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The generation of nisin variants with enhanced activity against specific Gram-positive pathogens

(2008) Des Field et al.   MOLECULAR MICROBIOLOGY

A global assembly line for cyanobactins

(2008) Mohamed S Donia et al.   Nature Chemical Biology

Discovery of a widely distributed toxin biosynthetic gene cluster

(2008) S. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA