Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition

Development of GlcNAc-Inspired Iminocyclitiols as Potent and SelectiveN-Acetyl-β-Hexosaminidase Inhibitors

(2010) Ching-Wen Ho et al.   ACS Chemical Biology

Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner

(2010) Boglarka Laczy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

β-N-Acetylhexosaminidase: What's in a name…?

(2010) Kristýna Slámová et al.   BIOTECHNOLOGY ADVANCES

Synthesis, Evaluation, and Mechanism of N,N,N-Trimethyl-D-glucosamine-(1→4)-chitooligosaccharides as Selective Inhibitors of Glycosyl Hydrolase Family 20 β-N-Acetyl-D-hexosaminidases

(2010) You Yang et al.   CHEMBIOCHEM

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

(2010) Matthew S. Macauley et al.   CHEMISTRY & BIOLOGY

Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine hexosaminidase inhibitors

(2010) J.S. Shane Rountree et al.   COMPTES RENDUS CHIMIE

Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells

(2010) Stephanie D. Boomkamp et al.   GLYCOCONJUGATE JOURNAL

Interconversion of the Specificities of Human Lysosomal Enzymes Associated with Fabry and Schindler Diseases

(2010) Ivan B. Tomasic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases

(2010) Daniel Best et al.   TETRAHEDRON LETTERS

4-C-Me-DAB and 4-C-Me-LAB—enantiomeric alkyl-branched pyrrolidine iminosugars—are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group

(2010) Filipa P. da Cruz et al.   TETRAHEDRON LETTERS

Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

(2010) Daniel Best et al.   TETRAHEDRON-ASYMMETRY

Mechanistic Investigation of the Endo-α-N-acetylgalactosaminidase fromStreptococcus pneumoniaeR6

(2009) Lisa M. Willis et al.   BIOCHEMISTRY

Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent β-N-acetylglucosaminidase inhibitor

(2009) Hirokazu Usuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

GlcNAc-Thiazoline conformations

(2009) Spencer Knapp et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: Association to tumor derived alpha-N-acetylgalactosaminidase activity

(2009) Marilena Greco et al.   CANCER LETTERS

Sugar-mimicking glycosidase inhibitors: bioactivity and application

(2009) N. Asano   CELLULAR AND MOLECULAR LIFE SCIENCES

Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease

(2009) J. S. Shane Rountree et al.   ChemMedChem

Glycomimetics at the Mirror: Medicinal Chemistry of L-Iminosugars

(2009) Daniele D'Alonzo et al.   CURRENT MEDICINAL CHEMISTRY

Identification of a Pneumococcal Glycosidase That Modifies O-Linked Glycans

(2009) C. Marion et al.   INFECTION AND IMMUNITY

Crystallographic and Mutational Analyses of Substrate Recognition of Endo-α-N-acetylgalactosaminidase from Bifidobacterium longum

(2009) Ryuichiro Suzuki et al.   JOURNAL OF BIOCHEMISTRY

Catalytic Mechanism of Human α-Galactosidase

(2009) Abigail I. Guce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 1.9 Å Structure of Human α-N-Acetylgalactosaminidase: The Molecular Basis of Schindler and Kanzaki Diseases

(2009) Nathaniel E. Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

Pharmacokinetics, safety and tolerability of miglustat in the treatment of pediatric patients with GM2 gangliosidosis

(2009) Gustavo H.B. Maegawa et al.   MOLECULAR GENETICS AND METABOLISM

Lysosomal Storage Disorders in the Newborn

(2009) O. Staretz-Chacham et al.   PEDIATRICS

Large scale synthesis of the acetonides of l-glucuronolactone and of l-glucose: easy access to l-sugar chirons

(2009) Alexander C. Weymouth-Wilson et al.   TETRAHEDRON LETTERS

Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-d-lyxitol [a potent competitive inhibitor of α-d-galactosidase] and of 1,4-dideoxy-1,4-imino-l-lyxitol [a weak competitive inhibitor of α-d-galactosidase] inhibit naringinase, an α-l-rhamnosidase competitively

(2009) Thomas B. Mercer et al.   TETRAHEDRON-ASYMMETRY

2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors

(2009) Andreas J. Steiner et al.   TETRAHEDRON-ASYMMETRY

Chiral Toxicology: It's the Same Thing…Only Different

(2009) Silas W. Smith   TOXICOLOGICAL SCIENCES

Molecular cloning, expression, and characterization of a novel endo-α-N-acetylgalactosaminidase from Enterococcus faecalis

(2008) Hatsumi M. Goda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum α-glucosidase inhibition

(2008) Dominic S. Alonzi et al.   BIOCHEMICAL JOURNAL

Characterization of two different endo- -N-acetylgalactosaminidases from probiotic and pathogenic enterobacteria, Bifidobacterium longum and Clostridium perfringens

(2008) H. Ashida et al.   GLYCOBIOLOGY

Novel endo- -N-acetylgalactosaminidases with broader substrate specificity

(2008) D. Koutsioulis et al.   GLYCOBIOLOGY

Synthesis and Biological Evaluation of Guanidine-Type Iminosugars

(2008) Matilde Aguilar et al.   JOURNAL OF ORGANIC CHEMISTRY