Article
Chemistry, Physical
Onajite T. Diejomaoh Abafe, Muhammad Mohsin Azim, Bice S. Martincigh, Annegret Stark
Summary: This study investigates the physicochemical properties of a series of cation-fluorinated ionic liquids and provides experimental evidence for nanosegregation and triphilicity in these liquids. The introduction of fluoroalkyl chains enhances hydrogen bond interactions between anions and cations and leads to structural rearrangements. The study also demonstrates the use of a group contribution method to predict the density of the liquids.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Marcia M. S. Alves, Manuel N. Melo, Haydyn D. T. Mertens, Ana B. Pereiro, Margarida Archer
Summary: Proteins can be stabilized and have improved properties in the presence of ionic liquids (ILs) as cosolvents or surfactants. By using techniques such as small-angle X-ray scattering (SAXS), fluorescence microscopy, and coarse-grained molecular dynamics (CG-MD) simulations, the interaction between ILs and proteins like lysozyme and bovine serum albumin has been studied. The results show that ILs help maintain the globular structures of proteins and can be used for formulating protein-based pharmaceuticals.
Article
Chemistry, Multidisciplinary
Shoki Hoshikawa, Hikaru Yanai, Irene Martin-Mejias, Carlos Lazaro-Milla, Cristina Aragoncillo, Pedro Almendros, Takashi Matsumoto
Summary: The carboarylation reaction of biphenyl-alkynes was successfully initiated by electrophilic attack of 1,1-bis(triflyl)ethylene on the alkyne moiety, resulting in polycyclic aromatic hydrocarbons decorated with superacidic carbon acid functionality. Neutralization of the obtained acids with NaHCO3 produced sodium salts with improved solubility in both aqueous and organic solvents.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Owen J. Curnow, Rathiga Senthooran
Summary: A series of highly-fluorinated triaminocyclopropenium salts were prepared and their properties as ionic liquids were investigated. Different cations were obtained by reacting pentachlorocyclopropane or tetrachlorocyclopropene with bis(2,2,2-trifluoroethyl)amine and a trialkylamine. The salts were characterized by thermal measurements, solubility properties, density, viscosity, and conductivity, and X-ray diffraction studies showed the formation of fluorous and hydrophilic regions.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Marcia M. S. Alves, Paula Leandro, Haydyn D. T. Mertens, Ana B. Pereiro, Margarida Archer
Summary: This study reveals that a biocompatible fluorinated ionic liquid can serve as a delivery system for human phenylalanine hydroxylase, increasing its enzymatic activity but impacting its thermostability.
Article
Chemistry, Multidisciplinary
Oriele Palumbo, Giovanni Battista Appetecchi, Giovanna Maresca, Jean-Blaise Brubach, Pascale Roy, Simone Di Muzio, Francesco Trequattrini, Delphine Bordignon, Florine Legrand, Anais Falgayrat, Rongying Lin, Sebastien Fantini, Annalisa Paolone
Summary: In this study, novel ionic liquid electrolytes were successfully synthesized and investigated. These electrolytes exhibited high thermal stability and glass transition characteristics at low temperatures. The infrared spectroscopy measurements and ion transport properties of the electrolytes were in good agreement with calculations. Furthermore, the electrolytes showed remarkable electrochemical stability at high voltages, making them suitable for high reliability lithium battery systems.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Physical
Viktor I. Petrenko, Liliana C. Fernandes, Oleksandr I. Ivankov, Carmen R. Tubio, Mohammad Tariq, Jose M. S. S. Esperanca, Daniela M. Correia, Senentxu Lanceros-Mendez
Summary: Hybrid materials based on ionic liquids (ILs) and polymers are widely used for the development of smart and multifunctional materials. However, the structural organization of ILs within the polymer matrix is not well understood. This study investigates the structural organization of different ILs incorporated into polyvinylidene fluoride (PVDF) films and analyzes their effects on the morphological and physical-chemical properties of the materials.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Carla Rizzo, Ignazio Fiduccia, Silvestre Buscemi, Antonio Palumbo Piccionello, Andrea Pace, Ivana Pibiri
Summary: The synthesis and thermotropic behavior of certain di-alkyloxy-phenyl-1,2,4-triazolium trifluoromethanesulfonate salts with a seven-carbon atom perfluoroalkyl chain on the cation were investigated. The fluorinated salts exhibited typical liquid crystalline behavior, with a 1,2,4-triazole core and varying lengths of alkyl chains on the phenyl ring. The mesomorphic properties of these salts were studied using differential scanning calorimetry and polarized optical microscopy. The results showed the presence of a monotropic, columnar, liquid crystalline phase in the tested salts, with an increased temperature mesophase range and the presence of two enantiotropic mesophases observed with the increase in alkyl chain length on the phenyl ring.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Organic
Marcos Escolano, Daniel Gavina, Santiago Diaz-Oltra, Maria Sanchez-Rosello, Carlos del Pozo
Summary: The enantioselective synthesis of fluorinated indolizidinone derivatives is achieved through an intramolecular aza-Michael reaction, followed by dimethyltitanocene methylenation and ring closing metathesis (RCM). The final products contain a fluorine-containing tetrasubstituted double bond generated by the RCM reaction, demonstrating high challenge. The synthetic sequence exhibits excellent enantioselectivities with acceptable overall yields.
Article
Chemistry, Physical
Jixia Wang, Yabing Tian, Shiguo Zhang, Yan Zhang
Summary: This study successfully synthesized chiral porous poly(ionic liquid)s (CPPILs) containing chiral salen Mn(III) complex, which showed excellent catalytic performance in asymmetric synthesis. These catalysts possess large specific surface area, abundant pore structure, and ionic active sites, and can efficiently catalyze the epoxidation of styrene. Moreover, these catalysts exhibit good stability and recyclability.
APPLIED CATALYSIS A-GENERAL
(2022)
Article
Biochemistry & Molecular Biology
Yuki Shigenobu, Aoi Nakashima, Jun-ichi Kadokawa
Summary: In this study, chitin benzoate stearates with thermoplasticity were synthesized through acylation reaction in an ionic liquid. The introduction of benzoyl and stearoyl groups resulted in the formation of products with regular crystalline structures, which exhibited melting points and could be processed into films during melt-pressing.
Review
Biochemistry & Molecular Biology
Justyna Wieclawik, Anna Chrobok
Summary: The chemical industry needs environmentally friendly processes, as acid-catalysed processes may cause environmental problems. The search for sustainable alternatives to conventional acids is urgent. Metal-containing ionic liquids have been of great interest to scientists due to their high Lewis acidity, which depends on the composition of the ionic liquid and the specific content of metal salt. These compounds are widely used as catalysts, co-catalysts, or reaction media in various fields of chemistry, particularly in organic chemistry. Gallium(III)- and indium(III)-containing ionic liquids effectively enhance the activity of metal salts and are easier to handle. This review emphasizes the wide range of applications and the potential of metal-containing ionic liquids, with a focus on Ga(III) and In(III), which can guide further research and synthesis of new compounds in this group.
Article
Chemistry, Multidisciplinary
Silke Wolf, Claus Feldmann
Summary: This article presents the synthesis and characterization of the pseudo-ternary tin(II) halide [BMPyr]2[SnCl4] by simply mixing the starting materials [BMPyr]Cl and SnCl2 at room temperature. The compound exhibits bright Sn(II)-based emission of deep-red light with a quantum yield of 88±3% after optimized synthesis. Characterization is performed using X-ray structure analysis, infrared, and fluorescence spectroscopy, and exemplary fluorescent thin films are achieved by solvent processing.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Silke Wolf, Claus Feldmann
Summary: The pseudo-ternary tin(ii) halide [BMPyr]2[SnCl4] can be easily synthesized by mixing [BMPyr]Cl and SnCl2 at room temperature without additional solvents. The compound exhibits bright deep-red emission (lambda max: 740 nm) with a high quantum yield (88 +/- 3%) after optimized synthesis. Characterization includes X-ray structure analysis, infrared and fluorescence spectroscopy. Exemplary fluorescent thin films are prepared through solvent processing.
CHEMICAL COMMUNICATIONS
(2023)
Article
Energy & Fuels
Yue Wang, Lingfeng Chao, Tingting Niu, Deli Li, Qi Wei, Hui Wu, Jian Qiu, Hui Lu, Chenxin Ran, Qi Zhong, Lin Song, Guichuan Xing, Yingdong Xia, Yonghua Chen, Peter Mueller-Buschbaum, Wei Huang
Summary: A novel strategy to enhance the performance and stability of organic halide perovskite solar cells by adding a small amount of the ionic liquid MA(+)DFA(-) is reported. The ionic liquid can anchor the organic cations via hydrogen bonding and improve the Pb-O interaction, leading to improved stability and superior photo carrier dynamics. Devices with high efficiency and excellent stability over 180 days in a nitrogen atmosphere at room temperature are achieved with the ionic liquid.
Article
Chemistry, Physical
Mario Martinez-Mingo, Andres Garcia-Viada, Ines Alonso, Nuria Rodriguez, Ramon Gomez Arrayas, Juan C. Carretero
Summary: The use of a removable N-(2-pyridyl)sulfonyl directing group provides a viable solution to overcome the limitation of blocking the more reactive gamma-position, allowing for the expansion of the scope of Pd-catalyzed delta-C-H arylation. This method is compatible with complex, multifunctional structures at either reaction partner. Experimental and density functional theory studies offer insights into the factors controlling site selectivity.
Article
Chemistry, Organic
Luis Novoa, Laura Trulli, Israel Fernandez, Alejandro Parra, Mariola Tortosa
Summary: In this study, a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes is presented. A wide variety of boryiated spirocycles have been prepared with complete regiocontrol using inexpensive copper salt and a commercially available bidentate phosphine. The boryl moiety serves as a synthetic handled for further functionalization, allowing access to a diverse array of spirocyclic building blocks from a common intermediate.
Article
Construction & Building Technology
J. F. San Jose Alonso, M. A. Sanz-Tejedor, Y. Arroyo, M. R. San Jose-Gallego
Summary: This study quantifies the air flow entering the operating room during the process of door opening and closing, and finds that sliding doors can reduce the entry of air from adjacent areas.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Mario Martinez-Mingo, Andres Garcia-Viada, Daniel Sowa Prendes, Ines Alonso, Nuria Rodriguez, Ramon Gomez Arrayas, Juan C. Carretero
Summary: The selective delta-C(sp(3))-H acetoxylation of N-(SO2Py)-protected amino acid derivatives has been achieved using palladium-catalysis and PhI(OAc)(2) as both oxidant and acetoxy source. The unique structural and electronic features of SO2Py are crucial in overriding the more favorable intramolecular C-H amination.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Energy & Fuels
A. Castellanos-Antolin, F. J. Rey-Martinez, L. J. San Jose-Gallego, Y. Arroyo-Gomez, J. M. Rey-Hernandez, J. F. San Jose-Alonso
Summary: This paper evaluates the energy savings achieved by introducing ventilation flow control and regulation systems in operating rooms of hospitals located in different climatic zones within Spain. Two control and regulation strategies of the air flow to be supplied and extracted in the operating rooms, during periods of inactivity, are studied. The results show significant energy savings.
Article
Chemistry, Organic
Emily L. Vargas, Mario Franco, Ines Alonso, Mariola Tortosa, M. Belen Cid
Summary: B(2)nep efficiently promotes N-O cleavage of nitrones to form imines in high yields via a simple, efficient, sustainable, functional group tolerant, and scalable protocol. The reaction occurs in the absence of additives through a concerted mechanism. We showed that DMPO and TEMPO, typically used as radical traps, are also deoxygenated by diboron reagents, revealing their limitations as mechanistic probes.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Marina Velado, Manuel Martinovic, Ines Alonso, Mariola Tortosa, Roberto Fernandez de la Pradilla, Alma Viso
Summary: The base-induced [2,3]-sigmatropic rearrangement of enantiopure 2-sulfinyl dienes has been optimized using NaH and iPrOH. The reaction proceeds through allylic deprotonation and sulfoxide-sulfenate rearrangement. The presence of a terminal allylic alcohol is crucial for achieving complete regioselectivity and high enantioselectivities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Marcos Escolano, Daniel Gavina, Santiago Diaz-Oltra, Maria Sanchez-Rosello, Carlos del Pozo
Summary: The enantioselective synthesis of fluorinated indolizidinone derivatives is achieved through an intramolecular aza-Michael reaction, followed by dimethyltitanocene methylenation and ring closing metathesis (RCM). The final products contain a fluorine-containing tetrasubstituted double bond generated by the RCM reaction, demonstrating high challenge. The synthetic sequence exhibits excellent enantioselectivities with acceptable overall yields.
Article
Chemistry, Organic
Angel Manu Martinez, Alejandro Puet, Gema Dominguez, Ines Alonso, Rodrigo Castro-Biondo, Javier Perez-Castells
Summary: In this article, the use of cyclopropene as a dienophile for the intramolecular Diels-Alder vinylarene reaction (IMDAV) is described. The strain energy of cyclopropene is utilized to drive the reaction, resulting in good yields, excellent stereoselectivity, and broad functional tolerance. Theoretical calculations and NMR studies provide significant mechanistic insights.
Article
Multidisciplinary Sciences
Javier M. Rey-Hernandez, Yolanda Arroyo-Gomez, Julio F. San Jose-Alonso, Francisco J. Rey-Martinez
Summary: This study investigates the natural ventilation in a rural elementary school and its impact on thermal comfort and infection risk. The results show that the school has good natural ventilation, with temperature and humidity meeting regulatory requirements and low infection risk.
Article
Chemistry, Multidisciplinary
Christian Cristobal, Daniel Gavina, Ines Alonso, Maria Ribagorda, Juan C. Carretero, Carlos del Pozo, Javier Adrio
Summary: An enantioselective synthesis of polycyclic fluorinated pyrrolidines has been achieved by Cu-catalyzed intramolecular 1,3-dipolar cycloaddition. The method enables the formation of desired products with high yields and up to 99% enantiomeric excess, indicating the excellent activating role of fluoroalkyl substituents in this transformation.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Javier Torres, Marcos Escolano, Gloria Alzuet-Pina, Maria Sanchez-Rosello, Carlos del Pozo
Summary: A new methodology has been developed to access the quinolizidine skeleton asymmetrically, involving two consecutive intramolecular aza-Michael reactions of sulfinyl amines with bis-enone moieties. The method, which has excellent yields and diastereocontrol, was successfully applied to the total synthesis of alkaloids lasubine I and myrtine.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Alvaro Sanz-Vidal, Daniel Gavina, Lia Sotorrios, Enrique Gomez-Bengoa, Fernando Lopez Ortiz, Maria Sanchez-Rosello, Carlos del Pozo
Summary: This novel synthesis strategy for polycyclic trifluoromethyl arenes involves a DBU-promoted tandem cycloaromatization reaction, resulting in a metal-free and air-tolerant process. It enables the synthesis of these compounds from readily available starting materials under mild reaction conditions.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Mario Martinez-Mingo, Ines Alonso, Nuria Rodriguez, Ramon Gomez Arrayas, Juan C. Carretero
Summary: Mechanistic insights into chemoselectivity control in Pd-catalyzed reactions have enabled the access to different heterocyclic frameworks from the same starting substrate by manipulating the reaction conditions.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
