Review
Biochemistry & Molecular Biology
Li Ma, Mengmeng Zhang, Rong Zhao, Dan Wang, Yuerong Ma, Li Ai
Summary: Cancer is a major threat to human health and safety, with a lack of safe and effective therapeutic drugs. Intervening and preventing in the premalignant process is an effective way to reverse carcinogenesis. Plant natural products are promising sources for cancer chemoprevention due to their richness in sources.
Review
Chemistry, Organic
Guillermo Valdomir, Lutz F. Tietze
Summary: In this Review, the isolation, structural elucidation, bioactivity, and synthesis of chromanone lactones are discussed. A classification of the different compounds in this family is presented.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Mohammad El-Harakeh, Sara Al-Ghadban, Remi Safi
Summary: Skin cancer is a major cause of mortality worldwide, divided into melanoma and non-melanoma cancers. While conventional therapies have improved, searching for chemopreventive compounds is still considered the safest strategy for cancer treatment.
CURRENT DRUG TARGETS
(2021)
Review
Biochemistry & Molecular Biology
Kanchan Gairola, Shriya Gururani, Ananya Bahuguna, Vaishali Garia, Rohit Pujari, Shiv K. Dubey
Summary: Cancer is a major global challenge and targeting cancer stem cells may be a novel strategy for elimination of the chronic disease. Natural products have shown potential in inhibiting tumorigenesis and modulating signaling pathways related to CSC self-renewal and differentiation, with minimal toxicity compared to traditional therapies.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Rasha Irshad, Mohammad Husain
Summary: Advancements in technology have highlighted the significance of deregulated epigenetic mechanisms in cancer, with natural products showing potential in modulating these aberrations. Plant-derived compounds have been explored as potential candidates for anti-cancer therapies due to their ability to target epigenetic markers.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Plant Sciences
Andrea Areal, Marta Dominguez, Pim Vendrig, Susana Alvarez, Rosana Alvarez, Angel R. de Lera
Summary: The total synthesis and structural confirmation of homo- and heterodimeric bispyrrolidinoindoline dioxopiperazine alkaloids isolated from fungi and bacteria have been successfully achieved. The study revealed structural factors that determine the rate and efficiency of ring formation, leading to the formation of mixtures of diastereomers and their putative monomeric precursors, as well as an alternative pathway for dimer formation with a fused heterocycle.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Oncology
Pankaj Garg, Rachana Garg, David Horne, Sanjay Awasthi, Ravi Salgia, Sharad S. Singhal
Summary: Cancer is a widespread and constantly evolving disease that poses a significant public health concern. Despite advancements in treatment strategies, such as surgery, radiation, and pharmaceutical therapies, there has been little improvement in cancer-related death rates. As a result, natural product-based therapeutic discoveries are being considered as an alternative approach. Primary prevention plays a crucial role in global cancer control, and this review provides an overview of the mechanisms by which bioactive ingredients in natural dietary products may contribute to the prevention and management of various malignancies.
Review
Pharmacology & Pharmacy
Soon Yong Park, Hyeongrok Choi, Jin Woong Chung
Summary: Natural products have historically been important sources of therapeutic drugs and continue to hold great potential in the field of medicinal natural products. Reptiles, as a traditional source of medicine in Asia, have been found to possess anti-cancer properties. Recent studies have shown that extracts, peptides, sera, and venom obtained from reptiles can effectively inhibit the survival and proliferation of cancer cells. This article provides a summary of recent research on the use of reptile-derived ingredients in cancer therapy and discusses the challenges and potential development of natural product research.
Review
Nutrition & Dietetics
Henry J. J. Thompson, Tymofiy Lutsiv
Summary: Great progress has been made in cancer treatment through the use of small molecule inhibitors called protein kinases, which are produced by genes that are known drivers of specific types of cancer. However, the high cost and limited accessibility of these newly developed drugs pose challenges for most parts of the world. This narrative review explores how these successful cancer treatment strategies can be reverse-engineered into affordable and accessible approaches for the global community, with a focus on cancer chemoprevention.
Review
Oncology
Meng Guo, Jie Jin, Dong Zhao, Zheng Rong, Lu-Qi Cao, Ai-Hong Li, Xiao-Ying Sun, Li-Yi Jia, Yin-Di Wang, Ling Huang, Yi-Heng Li, Zhong-Jing He, Long Li, Rui-Kang Ma, Yi-Fan Lv, Ke-Ke Shao, Hui-Ling Cao
Summary: Malignant tumors pose a serious threat to people's health and lives worldwide. Natural products, which have definite pharmacological effects and known chemical structures, exhibit favorable anti-cancer activity and combine the advantages of Chinese herbs and chemotherapeutic drugs. This review focuses on the latest advances in anti-cancer activity of representative natural products in different chemical classes, as well as the molecular mechanisms and derivatization of these products, providing new insights and core structures for the development of anti-cancer drugs.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mariia Zadorozhna, Domenica Mangieri
Summary: Ginger, a commonly used spice and medicinal plant, exhibits anti-inflammatory, antioxidant, and anti-tumor properties. Recent studies have shown that ginger extracts have chemopreventive characteristics against cancer by disrupting crucial processes such as cell survival, proliferation, and dissemination of cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Shuli Man, Chen Luo, Mengyao Yan, Ganggang Zhao, Long Ma, Wenyuan Gao
Summary: This article discusses the formation process and therapeutic targets of liver cancer, as well as the current development of natural products in anti-liver cancer treatment. It points out the potential advantages of natural products in intervening in the formation and development of liver cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Summary: The MAPK pathway plays a crucial role in transmitting signals from outside the cell to inside, and is associated with cancer treatment response, normal cell pathway maintenance, and compensatory pathway activation. MAPK inhibitors often activate compensatory feedback loops, leading to resistance in tumor cells and microenvironment. Therefore, innovative combination therapies are needed to limit alternate pathway initiation.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Sydney D. Stokes, Cade C. Lewis, Trenton G. Mayberry, Mark R. Wakefield, Yujiang Fang
Summary: This article discusses the feasibility of using natural agents as treatments for prostate cancer and its complications. The study found that simple treatments such as green tea, pomegranate, and regular exercise may be effective against prostate cancer.
Review
Biochemistry & Molecular Biology
Guo-Qing Chen, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Xiaoting Li, Tian Luan
Summary: This review summarizes the structure, biological activity, and mechanism of natural product derivatives containing pyrazine fragments reported from 2000 to September 2023. The results show that pyrazine-modified natural product derivatives have a wide range of biological activities and lower toxicity.
Article
Chemistry, Medicinal
Fulvia Orsini, Luisella Verotta, Karin Klimo, Clarissa Gerhaeuser
ARCHIV DER PHARMAZIE
(2016)
Article
Chemistry, Organic
Oualid Talhi, Lidia Brodziak-Jarosz, Jana Panning, Barbora Orlikova, Clemens Zwergel, Tzvetomira Tzanova, Stephanie Philippot, Diana C. G. A. Pinto, Filipe A. Almeida Paz, Clarissa Gerhaeuser, Tobias P. Dick, Claus Jacob, Marc Diederich, Denyse Bagrel, Gilbert Kirsch, Artur M. S. Silva
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Genetics & Heredity
Reiner Siebert, Clarissa Gerhaeuser, Ronald Simon, Rabea Wagener, Ursula D. Weber, Guido Sauter, Christoph Plass, Peter Lichter
MEDIZINISCHE GENETIK
(2016)
Article
Genetics & Heredity
David Brocks, Christopher R. Schmidt, Michael Daskalakis, Hyo Sik Jang, Nakul M. Shah, Daofeng Li, Jing Li, Bo Zhang, Yiran Hou, Sara Laudato, Daniel B. Lipka, Johanna Schott, Holger Bierhoff, Yassen Assenov, Monika Helf, Alzbeta Ressnerova, Md Saiful Islam, Anders M. Lindroth, Simon Haas, Marieke Essers, Charles D. Imbusch, Benedikt Brors, Ina Oehme, Olaf Witt, Michael Luebbert, Jan-Philipp Mallm, Karsten Rippe, Rainer Will, Dieter Weichenhan, Georg Stoecklin, Clarissa Gerhaeuser, Christopher C. Oakes, Ting Wang, Christoph Plass
Article
Biochemistry & Molecular Biology
K. Heilmann, R. Toth, C. Bossmann, K. Klimo, C. Plass, C. Gerhauser
Article
Oncology
Dyah L. Dewi, Soumya R. Mohapatra, Saioa Blanco Cabanes, Isabell Adam, Luis F. Somarribas Patterson, Bianca Berdel, Masroor Kahloon, Loreen Thuemann, Stefanie Loth, Katharina Heilmann, Dieter Weichenhan, Oliver Muecke, Ines Heiland, Pauline Wimberger, Jan Dominik Kuhlmann, Karl-Heinz Kellner, Sarah Schott, Christoph Plass, Michael Platten, Clarissa Gerhaeuser, Saskia Trump, Christiane A. Opitz
Article
Cell Biology
Veronica Valli, Katharina Heilmann, Francesca Danesi, Alessandra Bordoni, Clarissa Gerhaeuser
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Review
Biology
Clarissa Gerhauser
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Article
Oncology
Yassen Assenov, David Brocks, Clarissa Gerhaeuser
SEMINARS IN CANCER BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Geoffrey Istas, Ken Declerck, Maria Pudenz, Katarzyna Szarc Vel Szic, Veronica Lendinez-Tortajada, Montserrat Leon-Latre, Karen Heyninck, Guy Haegeman, Jose A. Casasnovas, Maria Tellez-Plaza, Clarissa Gerhauser, Christian Heiss, Ana Rodriguez-Mateos, Wim Vanden Berghe
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Dragan Milenkovic, Wim Vanden Berghe, Christine Morand, Sylvain Claude, Annette van de Sandt, Simone Gorressen, Laurent-Emmanuel Monfoulet, Chandra S. Chirumamilla, Ken Declerck, Katarzyna Szarc Vel Szic, Maija Lahtela-Kakkonen, Clarissa Gerhauser, Marc W. Merx, Malte Kelm
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Clarissa Gerhauser, Francesco Favero, Thomas Risch, Ronald Simon, Lars Feuerbach, Yassen Assenov, Doreen Heckmann, Nikos Sidiropoulos, Sebastian M. Waszak, Daniel Huebschmann, Alfonso Urbanucci, Etsehiwot G. Girma, Vladimir Kuryshev, Leszek J. Klimczak, Natalie Saini, Adrian M. Stuetz, Dieter Weichenhan, Lisa-Marie Boettcher, Reka Toth, Josephine D. Hendriksen, Christina Koop, Pavlo Lutsik, Soeren Matzk, Hans-Joerg Warnatz, Vyacheslav Amstislayskiy, Clarissa Feuerstein, Benjamin Raeder, Olga Bogatyrova, Eva-Maria Schmitz, Claudia Hube-Magg, Martina Kluth, Hartwig Huland, Markus Graefen, Chris Lawerenz, Gervaise H. Henry, Takafumi N. Yamaguchi, Alicia Malewska, Jan Meiners, Daniela Schilling, Eva Reisinger, Roland Eils, Matthias Schlesner, Douglas W. Strand, Robert G. Bristow, Paul C. Boutros, Christof von Kalle, Dmitry Gordenin, Holger Sueltmann, Benedikt Brors, Guido Sauter, Christoph Plass, Marie-Laure Yaspo, Jan O. Korbel, Thorsten Schlomm, Joachim Weischenfeldt
Article
Sport Sciences
Alexander Schenk, Walter Pulverer, Christine Koliamitra, Claus Juergen Bauer, Suzana Ilic, Rudolf Heer, Robert Schier, Volker Schick, Bernd W. Boettiger, Clarissa Gerhaeuser, Wilhelm Bloch, Philipp Zimmer
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2019)
Article
Oncology
Mehdi Manoochehri, Nasim Borhani, Clarissa Gerhaeuser, Yassen Assenov, Maximilian Schoenung, Thomas Hielscher, Brock C. Christensen, Min Kyung Lee, Hermann-Josef Grone, Daniel B. Lipka, Thomas Bruening, Hiltrud Brauch, Yon-Dschun Ko, Ute Hamann
Summary: Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for earlier detection of triple-negative breast cancer (TNBC), aiding clinicians in easier and more efficient treatment options.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Leane Lehmann, Sebastian T. Soukup, Clarissa Gerhaeuser, Guenter Vollmer, Sabine E. Kulling
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ
(2017)
