Flexizymes-facilitated Genetic Code Reprogramming Leading to the Discovery of Drug-like Peptides

Reevaluation of the d-Amino Acid Compatibility with the Elongation Event in Translation

(2013) Tomoshige Fujino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

(2013) Yoshiki Tanaka et al.   NATURE

In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors

(2012) Yuuki Hayashi et al.   ACS Chemical Biology

Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2

(2012) Jumpei Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of the Backbone Cyclic Peptide Sunflower Trypsin Inhibitor-1 Promoted by the Induced Peptidyl-tRNA Drop-off

(2011) Taek Jin Kang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ribosomal Synthesis of Backbone-Macrocyclic Peptides Containing γ-Amino Acids

(2011) Yukinori Ohshiro et al.   CHEMBIOCHEM

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

(2011) Yusuke Yamagishi et al.   CHEMISTRY & BIOLOGY

Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins

(2011) T. Minematsu et al.   MOLECULAR CANCER THERAPEUTICS

Flexizymes for genetic code reprogramming

(2011) Yuki Goto et al.   Nature Protocols

Ribozyme-Catalyzed Transcription of an Active Ribozyme

(2011) A. Wochner et al.   SCIENCE

A flexizyme that selectively charges amino acids activated by a water-friendly leaving group

(2009) Nobuyoshi Niwa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ribosomal Synthesis of Peptides with C-Terminal Lactams, Thiolactones, and Alkylamides

(2009) Eiji Nakajima et al.   CHEMBIOCHEM

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Rapid and Simple Ribozymic Aminoacylation Using Three Conserved Nucleotides

(2009) N. V. Chumachenko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Translation Initiation with Initiator tRNA Charged with Exotic Peptides

(2009) Yuki Goto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diverse backbone-cyclized peptides via codon reprogramming

(2009) Takashi Kawakami et al.   Nature Chemical Biology

Reprogramming the Translation Initiation for the Synthesis of Physiologically Stable Cyclic Peptides

(2008) Yuki Goto et al.   ACS Chemical Biology

How Nature Morphs Peptide Scaffolds into Antibiotics

(2008) Elizabeth M. Nolan et al.   CHEMBIOCHEM

Expression of Histone H3 Tails with Combinatorial Lysine Modifications under the Reprogrammed Genetic Code for the Investigation on Epigenetic Markers

(2008) Taek Jin Kang et al.   CHEMISTRY & BIOLOGY

Messenger RNA-Programmed Incorporation of Multiple N-Methyl-Amino Acids into Linear and Cyclic Peptides

(2008) Takashi Kawakami et al.   CHEMISTRY & BIOLOGY

Ribosomal Synthesis of Polypeptoids and Peptoid−Peptide Hybrids

(2008) Takashi Kawakami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomal Synthesis of Bicyclic Peptides via Two Orthogonal Inter-Side-Chain Reactions

(2008) Yusuke Sako et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Initiating translation with D-amino acids

(2008) Y. Goto et al.   RNA